MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2651 to 2700 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
663	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Divided	High confidence	229.072	216.576	1.0577
	NDUFA6	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Subtracted		214.256	202.141	12.115
664	AGPAT4	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]		Low confidence	191.507	185.859	5.648
	PDXDC1	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]		High confidence	214.256	202.141	12.115
	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Divided		229.072	216.576	1.0577
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]		Low confidence	201.821	196.233	1.02848
665	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]		High confidence	229.072	216.576	1.0577
	HOXD9	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Subtracted		214.254	202.166	12.088
	PRSS7	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]		Low confidence	204.81	199.174	5.636
	SKP1A	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Divided		204.882	199.214	1.02845
666	CYP3A43	cytochrome p450 3a43 (ec 1.14.14.1). [swissprot;acc:q9hb55]	Subtracted		203.712	198.082	5.63
	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]		High confidence	250.465	238.38	12.085
	HES1	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	Divided		229.072	216.576	1.0577
	SOS2	son of sevenless protein homolog 2 (sos-2). [swissprot;acc:q07890]		Low confidence	200.639	195.092	1.02843
667	no value	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Subtracted	High confidence	250.465	238.38	12.085
	CHD3	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]		Low confidence	213.926	208.315	5.611
	ECH1	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	Divided	High confidence	229.072	216.576	1.0577
	RNF144B	ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]		Low confidence	208.62	202.855	1.02842
668	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]		High confidence	229.072	216.576	1.0577
	CYP3A7	cytochrome p450 3a7 (ec 1.14.14.1) (cypiiia7) (p450-hfla). [swissprot;acc:p24462]	Subtracted	Low confidence	203.727	198.116	5.611
	FTSJ3	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]		High confidence	244.495	232.419	12.076
	MIOX	inositol oxygenase (ec 1.13.99.1) (myo-inositol oxygenase) (aldehyde reductase-like 6) (renal-specific oxidoreductase) (kidney-specific protein 32). [swissprot;acc:q9ugb7]	Divided	Low confidence	212.062	206.202	1.02842
669	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	Subtracted	High confidence	232.601	244.534	11.933
	CHD5	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]		Low confidence	213.929	208.318	5.611
	CYP3A43	cytochrome p450 3a43 (ec 1.14.14.1). [swissprot;acc:q9hb55]	Divided		203.712	198.082	1.02842
	SYN1	synapsin i (brain protein 4.1). [swissprot;acc:p17600]		High confidence	229.072	216.576	1.0577
670	no value	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]		Low confidence	204.551	198.901	1.02841
	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	Subtracted		203.604	197.996	5.608
	GNL2	autoantigen ngp-1. [swissprot;acc:q13823]	Divided	High confidence	250.302	236.817	1.05694
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Subtracted		232.601	244.534	11.933
671	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	CYP3A5	cytochrome p450 3a5 (ec 1.14.14.1) (cypiiia5) (p450-pcn3). [swissprot;acc:p20815]		Low confidence	203.702	198.095	5.607
	ITGB1	integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	Divided		206.277	200.582	1.02839
	NUBP1	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]		High confidence	210.739	199.398	1.05688
672	no value	dok-like protein. [refseq;acc:nm_024872]	Subtracted		216.504	204.622	11.882
	CYP3A7	cytochrome p450 3a7 (ec 1.14.14.1) (cypiiia7) (p450-hfla). [swissprot;acc:p24462]	Divided	Low confidence	203.727	198.116	1.02832
	DDX54	atp-dependent rna helicase mgc2835; atp-dependent rna helicase; apoptosis related protein apr-5; dead box helicase 97 kda. [refseq;acc:nm_024072]	Subtracted		204.263	198.663	5.6
	NUBP2	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	Divided	High confidence	210.739	199.398	1.05688
673	CASK	peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]			226.497	214.355	1.05664
	CYP3A4	cytochrome p450 3a4 (ec 1.14.13.67) (quinine 3-monooxygenase) (cypiiia4) (nifedipine oxidase) (nf-25) (p450-pcn1). [swissprot;acc:p08684]	Subtracted	Low confidence	203.747	198.152	5.595
	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	Divided		203.604	197.996	1.02832
	DOK2	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Subtracted	High confidence	216.504	204.622	11.882
674	no value	adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]		Low confidence	205.207	199.613	5.594
	DOK1	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]		High confidence	216.504	204.622	11.882
	HIF3A	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	Divided		226.497	214.355	1.05664
	PRSS7	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]		Low confidence	204.81	199.174	1.0283
675	CYP3A5	cytochrome p450 3a5 (ec 1.14.14.1) (cypiiia5) (p450-pcn3). [swissprot;acc:p20815]			203.702	198.095
	FRK	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	Subtracted	High confidence	216.504	204.622	11.882
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]		Low confidence	201.821	196.233	5.588
	SIM1	single-minded homolog 1. [swissprot;acc:p81133]	Divided	High confidence	226.497	214.355	1.05664

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.