MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	description	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2608 to 2657 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	description	Hugo	Interaction Map	red	green	network_comparison
652	Subtracted	integrin alpha-7 precursor. [swissprot;acc:q13683]	ITGA7	Low confidence	206.32	200.601	5.719
653	Divided	dihydroorotate dehydrogenase, mitochondrial precursor (ec 1.3.3.1) (dihydroorotate oxidase) (dhodehase) (fragment). [swissprot;acc:q02127]	DHODH		203.975	198.304	1.0286
		dok-like protein. [refseq;acc:nm_024872]	no value	High confidence	216.504	204.622	1.05807
	Subtracted	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]	ITGA3	Low confidence	206.32	200.601	5.719
		interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	no value	High confidence	214.256	202.139	12.117
654	Divided	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	DOK2		216.504	204.622	1.05807
		zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]	ZEB2	Low confidence	205.995	200.27	1.02859
	Subtracted	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	JMJD6	High confidence	214.256	202.139	12.117
		ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	GULP1	Low confidence	203.911	198.193	5.718
655	Divided	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	DOK1	High confidence	216.504	204.622	1.05807
		transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]	ZEB1	Low confidence	205.995	200.27	1.02859
	Subtracted	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	GABRG1	High confidence	214.256	202.14	12.116
		hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	HEMK1	Low confidence	203.104	197.399	5.705
656	Divided	integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]	ITGB2		206.339	200.608	1.02857
		tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	FRK	High confidence	216.504	204.622	1.05807
	Subtracted	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	GABRA2		214.256	202.14	12.116
		integrin beta-1 precursor (fibronectin receptor beta subunit) (cd29 antigen) (integrin vla-4 beta subunit). [swissprot;acc:p05556]	ITGB1	Low confidence	206.277	200.582	5.695
657	Divided	integrin beta-7 precursor. [swissprot;acc:p26010]	ITGB7		206.341	200.609	1.02857
		synapsin iii. [swissprot;acc:o14994]	SYN3	High confidence	229.072	216.576	1.0577
	Subtracted	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	GABRA6		214.256	202.14	12.116
		protein ad-016 (protein cgi-116) (x0009). [swissprot;acc:q9y3c0]	CCDC53	Low confidence	207.03	201.339	5.691
658	Divided	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]	no value	High confidence	229.072	216.576	1.0577
		integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	ITGB3	Low confidence	206.342	200.61	1.02857
	Subtracted	brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	ARFGEF1		203.293	197.621	5.672
		gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	GABRG2	High confidence	214.256	202.14	12.116
659	Divided	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	HEY1		229.072	216.576	1.0577
		tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]	TP53I3	Low confidence	175.504	170.633	1.02855
	Subtracted	dihydroorotate dehydrogenase, mitochondrial precursor (ec 1.3.3.1) (dihydroorotate oxidase) (dhodehase) (fragment). [swissprot;acc:q02127]	DHODH		203.975	198.304	5.671
		gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	GABRA4	High confidence	214.256	202.14	12.116
660	Divided	actin binding lim protein 2. [refseq;acc:nm_032432]	ABLIM2		229.072	216.576	1.0577
		integrin alpha-7 precursor. [swissprot;acc:q13683]	ITGA7	Low confidence	206.32	200.601	1.02851
	Subtracted	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	GABRE	High confidence	214.256	202.14	12.116
		s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	SKP1A	Low confidence	204.882	199.214	5.668
661	Divided	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	HEYL	High confidence	229.072	216.576	1.0577
		son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	SOS1	Low confidence	200.62	195.059	1.02851
	Subtracted	brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldin a-inhibited gep 2). [swissprot;acc:q9y6d5]	ARFGEF2		203.283	197.617	5.666
		gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	GABRA1	High confidence	214.256	202.14	12.116
662	Divided	integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]	ITGA6	Low confidence	206.321	200.601	1.02851
		synapsin ii. [swissprot;acc:q92777]	SYN2	High confidence	229.072	216.576	1.0577
	Subtracted	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	GABRA3		214.256	202.14	12.116
		sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	no value	Low confidence	206.115	200.462	5.653
663	Divided	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]	ITGA3		206.32	200.601	1.02851
		mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	MRRF	High confidence	229.072	216.576	1.0577
	Subtracted	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	NDUFA6		214.256	202.141	12.115
		tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	no value	Low confidence	204.551	198.901	5.65
664	Divided	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	PEX5	High confidence	229.072	216.576	1.0577
		pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	PRPF31	Low confidence	201.821	196.233	1.02848
	Subtracted	1-acyl-sn-glycerol-3-phosphate acyltransferase delta (ec 2.3.1.51) (1- agp acyltransferase 4) (1-agpat 4) (lysophosphatidic acid acyltransferase-delta) (lpaat-delta) (1-acylglycerol-3-phosphate o- acyltransferase 4). [swissprot;acc:q9nrz5]	AGPAT4		191.507	185.859	5.648
		similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	PDXDC1	High confidence	214.256	202.141	12.115
665	Divided	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	HEY2		229.072	216.576	1.0577

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.