MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2601 to 2650 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1301	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	COPE	Subtracted	187.964	192.849	4.885
	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	TPD52L2	Divided	206.852	211.757	1.02371
1302	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]	CSMD1	Subtracted	218.509	213.648	4.861
	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	UQCRC1	Divided	217.624	212.584	1.02371
1303	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]	FHL5		269.157	275.531	1.02368
	zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	ZIC4	Subtracted	218.509	213.648	4.861
1304	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]	no value
	glutathione reductase, mitochondrial precursor (ec 1.8.1.7) (gr) (grase). [swissprot;acc:p00390]	GSR	Divided	207.387	212.275	1.02357
1305	calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]	RCAN2	Subtracted	218.509	213.649	4.86
	serine/threonine protein phosphatase 2b catalytic subunit, alpha isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, alpha isoform) (cam-prp catalytic subunit). [swissprot;acc:q08209]	PPP3CA	Divided	218.439	213.436	1.02344
1306	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	RCAN1	Subtracted	218.508	213.648	4.86
	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]	PPP3CC	Divided	218.441	213.441	1.02343
1307	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	RCAN3	Subtracted	218.509	213.649	4.86
	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	PPP3CB	Divided	218.44	213.44	1.02343
1308	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	OCA2			213.439
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	WRNIP1	Subtracted	217.133	212.289	4.844
1309	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]	EXO1		216.772	221.594	4.822
	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	VBP1	Divided	226.439	221.26	1.02341
1310	phd finger protein 9. [refseq;acc:nm_018062]	FANCL	Subtracted	216.772	221.594	4.822
	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	PFDN2	Divided	226.439	221.26	1.02341
1311	small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]	SOLH	Subtracted	216.772	221.594	4.822
	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	UXT	Divided	226.439	221.26	1.02341
1312	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	GALK2	Subtracted	215.162	210.412	4.75
	rad50 homolog isoform 1. [refseq;acc:nm_005732]	RAD50	Divided	199.739	204.407	1.02337
1313	galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	no value	Subtracted	215.162	210.412	4.75
	signal transducer and activator of transcription 3 (acute-phase response factor). [swissprot;acc:p40763]	STAT3	Divided	222.573	227.75	1.02326
1314	signal transducer and activator of transcription 4. [swissprot;acc:q14765]	STAT4			227.751
	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	GALE	Subtracted	215.162	210.412	4.75
1315	signal transducer and activator of transcription 1-alpha/beta (transcription factor isgf-3 components p91/p84). [swissprot;acc:p42224]	STAT1	Divided	222.574	227.752	1.02326
	zinc finger protein zic 1 (zinc finger protein of the cerebellum 1). [swissprot;acc:q15915]	ZIC1	Subtracted	218.569	213.832	4.737
1316	signal transducer and activator of transcription 6 (il-4 stat). [swissprot;acc:p42226]	STAT6	Divided	222.569	227.739	1.02323
	zinc finger protein zic 3 (zinc finger protein of the cerebellum 3). [swissprot;acc:o60481]	ZIC3	Subtracted	218.572	213.841	4.731
1317	centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	CENPJ	Divided	206.773	202.105	1.0231
	zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	ZIC2	Subtracted	218.574	213.847	4.727
1318	camp response element-binding protein cre-bpa. [refseq;acc:nm_004904]	CREB5		218.591	213.899	4.692
	signal transducer and activator of transcription 5a. [swissprot;acc:p42229]	STAT5A	Divided	222.546	227.673	1.02304
1319	centromere protein j; centrosomal p4.1-associated protein; lyst-interacting protein lip1; lag-3-associated protein. [refseq;acc:nm_018451]	CENPJ	Subtracted	206.773	202.105	4.668
	glycogen [starch] synthase, muscle (ec 2.4.1.11). [swissprot;acc:p13807]	GYS1	Divided	159.75	156.153	1.02304
1320	rad50 homolog isoform 1. [refseq;acc:nm_005732]	RAD50	Subtracted	199.739	204.407	4.668
	signal transducer and activator of transcription 5b. [swissprot;acc:p51692]	STAT5B	Divided	222.544	227.667	1.02302
1321	m-phase inducer phosphatase 3 (ec 3.1.3.48) (dual specificity phosphatase cdc25c). [swissprot;acc:p30307]	CDC25C	Subtracted	259.439	254.797	4.642
	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	DIMT1L	Divided	226.347	221.259	1.023
1322	endo-beta-n-acetylglucosaminidase. [refseq;acc:nm_022759]	no value		159.86	156.275	1.02294
	suppressor of cytokine signaling 1 (socs-1) (jak-binding protein) (jab) (stat induced stat inhibitor 1) (ssi-1) (tec-interacting protein 3) (tip-3). [swissprot;acc:o15524]	SOCS1	Subtracted	216.542	211.908	4.634
1323	cytoplasmic protein nck2 (nck adaptor protein 2) (sh2/sh3 adaptor protein nck-beta) (nck-2). [swissprot;acc:o43639]	NCK2	Divided	205.225	200.625	1.02293
	glia maturation factor gamma (gmf-gamma). [swissprot;acc:o60234]	GMFG	Subtracted	216.542	211.908	4.634
1324	asc-1 complex subunit p100. [refseq;acc:nm_032204]	ASCC2
	glycogen [starch] synthase, liver (ec 2.4.1.11). [swissprot;acc:p54840]	GYS2	Divided	159.993	156.421	1.02284
1325	fk506-binding protein 1a (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (12 kda fkbp) (fkbp-12) (immunophilin fkbp12). [swissprot;acc:p20071]	FKBP1A	Subtracted	216.542	211.908	4.634
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	WRNIP1	Divided	217.133	212.289	1.02282

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.