MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2575 to 2624 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1288	ACVR1C	activin a receptor, type ic; activin receptor-like kinase 7. [refseq;acc:nm_145259]	Subtracted	223.884	228.795	4.911
	CYP4B1	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	Divided	218.368	213.22	1.02414
1289	FLOT1	flotillin-1. [swissprot;acc:o75955]
	PAOX	peroxisomal n1-acetyl-spermine/spermidine oxidase. [refseq;acc:nm_152911]	Subtracted	228.644	223.736	4.908
1290	ATPIF1	atpase inhibitor, mitochondrial precursor. [swissprot;acc:q9uii2]
	SESN1	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	Divided	218.368	213.22	1.02414
1291	HAS2	hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]		221.093	226.399	1.024
	SMOX	polyamine oxidase isoform 1; polyamine oxidase; flavin-containing spermine oxidase; putative cyclin g1 interacting protein; flavin containing amine oxidase. [refseq;acc:nm_019025]	Subtracted	228.644	223.736	4.908
1292	CASP7	caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	Divided	233.942	228.46	1.024
	HCCS	cytochrome c-type heme lyase (ec 4.4.1.17) (cchl) (holocytochrome c- type synthase). [swissprot;acc:p53701]	Subtracted	228.644	223.736	4.908
1293	CASP3	apopain precursor (ec 3.4.22.-) (cysteine protease cpp32) (yama protein) (cpp-32) (caspase-3) (casp-3) (srebp cleavage activity 1) (sca-1). [swissprot;acc:p42574]	Divided	233.942	228.46	1.024
	TPD52L2	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	Subtracted	206.852	211.757	4.905
1294	GSTT1	glutathione s-transferase theta 1 (ec 2.5.1.18) (gst class-theta) (glutathione transferase t1-1). [swissprot;acc:p30711]		228.646	223.744	4.902
	HAS1	hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	Divided	221.093	226.399	1.024
1295	HAS3	hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]
	OXA1L	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]	Subtracted	220.681	215.78	4.901
1296	MRPL34	60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]
	SLC37A1	glycerol-3-phosphate transporter (g-3-p transporter) (g-3-p permease). [swissprot;acc:p57057]	Divided	209.062	204.174	1.02394
1297	PRODH	proline oxidase, mitochondrial precursor (ec 1.5.3.-) (proline dehydrogenase). [swissprot;acc:o43272]
	SF3B4	splicing factor 3b subunit 4 (spliceosome associated protein 49) (sap 49) (sf3b50) (pre-mrna splicing factor sf3b 49 kda subunit). [swissprot;acc:q15427]	Subtracted	232.752	237.65	4.898
1298	DLAT	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (ec 2.3.1.12) (e2) (pdc-e2) (70 kda mitochondrial autoantigen of primary biliary cirrhosis) (pbc) (m2 antigen complex 70 kda subunit). [swissprot;acc:p10515]	Divided	206.482	211.404	1.02384
	SLC37A1	glycerol-3-phosphate transporter (g-3-p transporter) (g-3-p permease). [swissprot;acc:p57057]	Subtracted	209.062	204.174	4.888
1299	GSR	glutathione reductase, mitochondrial precursor (ec 1.8.1.7) (gr) (grase). [swissprot;acc:p00390]		207.387	212.275
	PMPCB	mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	Divided	217.635	212.575	1.0238
1300	PMPCA	mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]		217.634	212.576	1.02379
	PRODH	proline oxidase, mitochondrial precursor (ec 1.5.3.-) (proline dehydrogenase). [swissprot;acc:o43272]	Subtracted	209.062	204.174	4.888
1301	COPE	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]		187.964	192.849	4.885
	TPD52L2	tumor protein d54 (hd54) (d52-like 2). [swissprot;acc:o43399]	Divided	206.852	211.757	1.02371
1302	CSMD1	dj947l8.1.6 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4w2]	Subtracted	218.509	213.648	4.861
	UQCRC1	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	Divided	217.624	212.584	1.02371
1303	FHL5	activator of camp-responsive element modulator (crem) in testis; lim protein act. [refseq;acc:nm_020482]		269.157	275.531	1.02368
	ZIC4	zinc finger protein zic 4 (zinc finger protein of the cerebellum 4) (fragment). [swissprot;acc:q8n9l1]	Subtracted	218.509	213.648	4.861
1304	no value	dj947l8.1.1 (novel cub and sushi (scr repeat) domain protein) (fragment). [sptrembl;acc:q9h4v7]
	GSR	glutathione reductase, mitochondrial precursor (ec 1.8.1.7) (gr) (grase). [swissprot;acc:p00390]	Divided	207.387	212.275	1.02357
1305	PPP3CA	serine/threonine protein phosphatase 2b catalytic subunit, alpha isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, alpha isoform) (cam-prp catalytic subunit). [swissprot;acc:q08209]		218.439	213.436	1.02344
	RCAN2	calcipressin 2 (thyroid hormone-responsive protein zaki-4) (down syndrome candidate region 1-like 1) (myocyte-enriched calcineurin interacting protein 2) (mcip2). [swissprot;acc:q14206]	Subtracted	218.509	213.649	4.86
1306	PPP3CC	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]	Divided	218.441	213.441	1.02343
	RCAN1	calcipressin 1 (down syndrome critical region protein 1) (myocyte- enriched calcineurin interacting protein 1) (mcip1) (adapt78). [swissprot;acc:p53805]	Subtracted	218.508	213.648	4.86
1307	PPP3CB	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	Divided	218.44	213.44	1.02343
	RCAN3	calcipressin 3 (down syndrome candidate region 1-like protein 2) (myocyte-enriched calcineurin interacting protein 3) (mcip3). [swissprot;acc:q9uka8]	Subtracted	218.509	213.649	4.86
1308	OCA2	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	Divided	218.44	213.439	1.02343
	WRNIP1	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Subtracted	217.133	212.289	4.844
1309	EXO1	exonuclease 1 isoform b; rad2 nuclease family member, homolog of s. cerevisiae exonuclease 1. [refseq;acc:nm_006027]		216.772	221.594	4.822
	VBP1	prefoldin subunit 3 (von hippel-lindau binding protein 1) (vhl binding protein-1) (vbp-1) (hibbj46). [swissprot;acc:q15765]	Divided	226.439	221.26	1.02341
1310	FANCL	phd finger protein 9. [refseq;acc:nm_018062]	Subtracted	216.772	221.594	4.822
	PFDN2	prefoldin subunit 2 (hspc231). [swissprot;acc:q9uhv9]	Divided	226.439	221.26	1.02341
1311	SOLH	small optic lobes homolog; small optic lobes, drosophila, homolog of. [refseq;acc:nm_005632]	Subtracted	216.772	221.594	4.822
	UXT	uxt protein (ubiquitously expressed transcript protein) (hspc024). [swissprot;acc:q9ubk9]	Divided	226.439	221.26	1.02341
1312	GALK2	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	Subtracted	215.162	210.412	4.75
	RAD50	rad50 homolog isoform 1. [refseq;acc:nm_005732]	Divided	199.739	204.407	1.02337

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.