MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 258 to 307 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
26s proteasome non-atpase regulatory subunit 2 (26s proteasome regulatory subunit s2) (26s proteasome subunit p97) (tumor necrosis factor type 1 receptor associated protein 2) (55.11 protein). [swissprot;acc:q13200]	1014	PSMD2	Subtracted	Squared	30653.9	34111.1	3457.2
	1241		Divided	Measured	6436.19	6980.13	1.08451
	1331		Subtracted	Rooted	65.478	68.0886	2.6106
	1395		Divided				1.03987
	1538			Squared	30653.9	34111.1	1.11278
	2169		Subtracted	Ranked	210.209	208.808	1.401
	2175		Divided				1.00671
26s proteasome non-atpase regulatory subunit 3 (26s proteasome regulatory subunit s3) (proteasome subunit p58). [swissprot;acc:o43242]	1268	PSMD3	Subtracted	Squared	26408.9	29370.7	2961.8
	1546		Divided	Measured	5819.39	6244.37	1.07303
	1548			Squared	26408.9	29370.7	1.11215
	1602		Subtracted	Measured	5819.39	6244.37	424.98
	1964		Divided	Rooted	62.1627	63.9151	1.02819
	1985		Subtracted				1.7524
	2423			Ranked	217.645	218.376	0.731
	2440		Divided				1.00336
26s proteasome non-atpase regulatory subunit 4 (26s proteasome regulatory subunit s5a) (rpn10) (multiubiquitin chain binding protein) (antisecretory factor-1) (af) (asf). [swissprot;acc:p55036]	1357	PSMD4	Subtracted	Squared	23913	26757.8	2844.8
	1377			Ranked	220.987	225.468	4.481
	1432		Divided				1.02028
	1439			Squared	23913	26757.8	1.11896
	1979			Measured	5475.74	5800.97	1.05939
	2018		Subtracted				325.23
	2482		Divided	Rooted	60.4511	61.1463	1.0115
	2495		Subtracted				0.6952
26s proteasome non-atpase regulatory subunit 6 (26s proteasome regulatory subunit s10) (p42a) (proteasome regulatory particle subunit p44s10). [swissprot;acc:q15008]	1055	PSMD6		Squared	27408.7	30747.3	3338.6
	1396		Divided				1.12181
	1414		Subtracted	Measured	5984.47	6435.42	450.95
	1472		Divided				1.07535
	1915			Rooted	63.054	64.872	1.02883
	1932		Subtracted				1.818
	2419			Ranked	215.807	216.556	0.749
	2432		Divided				1.00347
26s proteasome non-atpase regulatory subunit 7 (26s proteasome regulatory subunit s12) (proteasome subunit p40) (mov34 protein homolog). [swissprot;acc:p51665]	1259	PSMD7	Subtracted	Squared	26642.1	29622.1	2980
	1554		Divided				1.11185
	1571			Measured	5851.64	6273.4	1.07208
	1625		Subtracted				421.76
	2010			Rooted	62.3398	64.0462	1.7064
	2013		Divided				1.02737
	2350		Subtracted	Ranked	217.232	218.162	0.93
	2355		Divided				1.00428
26s proteasome non-atpase regulatory subunit 8 (26s proteasome regulatory subunit s14) (p31). [swissprot;acc:p48556]	1344	PSMD8	Subtracted	Squared	27060.6	29916.8	2856.2
	1532			Measured	5916.05	6350.53	434.48
	1536		Divided				1.07344
	1691			Squared	27060.6	29916.8	1.10555
	1861			Rooted	62.7784	64.64	1.02965
	1882		Subtracted				1.8616
	2519			Ranked	215.835	216.341	0.506
	2525		Divided				1.00234
26s proteasome non-atpase regulatory subunit 9 (26s proteasome regulatory subunit p27). [swissprot;acc:o00233]	1232	PSMD9	Subtracted	Squared	27762.4	30763.9	3001.5
	1460			Measured	5996.14	6439.46	443.32
	1517		Divided				1.07393

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.