MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2551 to 2600 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	red	green	network_comparison
2551	FBP2	fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	209.766	210.148	1.00182
2552	CDY1B	testis-specific chromodomain y protein 1. [swissprot;acc:q9y6f8]	193.12	193.467	1.0018
2553	CDYL	chromodomain protein, y chromosome-like isoform a; cdy-like, autosomal; testis-specific chromodomain y-like protein. [refseq;acc:nm_004824]
2554	CDY2B	testis-specific chromodomain protein y protein 2. [swissprot;acc:q9y6f7]
2555	MAT2A	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	212.953	212.572	1.00179
2556	CDYL2	chromodomain y-like protein 2. [refseq;acc:nm_152342]	193.119	193.46	1.00177
2557	EEF2	elongation factor 2 (ef-2). [swissprot;acc:p13639]	222.658	223.047	1.00175
2558	GRM2	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]
2559	no value	metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]
2560	MGLL	monoglyceride lipase; lysophospholipase-like. [refseq;acc:nm_007283]	202.395	202.042
2561	FBP1	fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	209.825	210.18	1.00169
2562	GYG1	glycogenin-1 (ec 2.4.1.186). [swissprot;acc:p46976]	208.429	208.779	1.00168
2563	ADK	adenosine kinase (ec 2.7.1.20) (ak) (adenosine 5'-phosphotransferase). [swissprot;acc:p55263]
2564	CRBN	protein x 0001. [refseq;acc:nm_016302]
2565	GYG2	glycogenin-2 (ec 2.4.1.186) (gn-2) (gn2). [swissprot;acc:o15488]
2566	AURKB	serine/threonine protein kinase 12 (ec 2.7.1.37) (aurora- and ipl1- like midbody-associated protein 1) (aim-1) (aurora/ipl1-related kinase 2) (aurora-related kinase 2) (stk-1) (aurora-b). [swissprot;acc:q96gd4]	219.907	220.267	1.00164
2567	KIF23	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [swissprot;acc:q02241]
2568	AURKC	serine/threonine protein kinase 13 (ec 2.7.1.37) (aurora/ipl1/eg2 protein 2) (aurora/ipl1-related kinase 3) (aurora-c). [swissprot;acc:q9uqb9]
2569	AURKA	serine/threonine kinase 6 (ec 2.7.1.37) (serine/threonine kinase 15) (aurora/ipl1-related kinase 1) (aurora-related kinase 1) (hark1) (aurora-a) (breast-tumor-amplified kinase). [swissprot;acc:o14965]
2570	CYLD	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]
2571	no value	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	209.549	209.205
2572	TAF12	transcription initiation factor tfiid 20/15 kda subunits (tafii- 20/tafii-15) (tafii20/tafii15). [swissprot;acc:q16514]	203.953	204.285	1.00163
2573	PRDX4	peroxiredoxin 4 (ec 1.11.1.-) (prx-iv) (thioredoxin peroxidase ao372) (thioredoxin-dependent peroxide reductase a0372) (antioxidant enzyme aoe372) (aoe37-2). [swissprot;acc:q13162]	213.347	213.005	1.00161
2574	SMARCC1	swi/snf-related matrix-associated actin-dependent regulator of chromatin c1; mammalian chromatin remodeling complex brg1-associated factor 155; swi/snf complex 155 kda subunit; chromatin remodeling complex baf155 subunit. [refseq;acc:nm_003074]	220.016	219.667	1.00159
2575	PTPN2	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	209.583	209.255	1.00157
2576	SNTB1	beta-1-syntrophin (59 kda dystrophin-associated protein a1, basic component 1) (dapa1b) (tax interaction protein 43) (tip-43) (syntrophin 2) (bsyn2). [swissprot;acc:q13884]	213.422	213.75	1.00154
2577	CANT1	ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; apyrase; soluble calcium-activated nucleotidase scan-1. [refseq;acc:nm_138793]	192.625	192.922
2578	SNTB2	beta-2-syntrophin (59 kda dystrophin-associated protein a1, basic component 2) (syntrophin 3) (snt3) (syntrophin-like) (sntl). [swissprot;acc:q13425]	213.422	213.75
2579	NIT1	nitrilase 1. [refseq;acc:nm_005600]
2580	UTRN	utrophin (dystrophin-related protein 1) (drp1) (drp). [swissprot;acc:p46939]
2581	DTNB	dystrobrevin beta (beta-dystrobrevin) (dtn-b). [swissprot;acc:o60941]	213.428	213.756
2582	DBT	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (ec 2.3.1.-) (e2) (dihydrolipoamide branched chain transacylase) (bckad e2 subunit). [swissprot;acc:p11182]	213.422	213.75
2583	DTNA	dystrobrevin alpha (dystrobrevin-alpha). [swissprot;acc:q9y4j8]	213.415	213.743
2584	no value	dystrophin. [swissprot;acc:p11532]	213.422	213.75
2585	AMOT	angiomotin. [refseq;acc:nm_133265]
2586	AMOTL2	angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]
2587	SNTA1	alpha-1-syntrophin (59 kda dystrophin-associated protein a1, acidic component 1) (pro-tgf-alpha cytoplasmic domain-interacting protein 1) (tacip1) (syntrophin 1). [swissprot;acc:q13424]
2588	HSPD1	60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	222.305	222.64	1.00151
2589	FAM57A	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	212.74	212.422	1.0015
2590	PSMA6	proteasome subunit alpha type 6 (ec 3.4.25.1) (proteasome iota chain) (macropain iota chain) (multicatalytic endopeptidase complex iota chain) (27 kda prosomal protein) (pros-27) (p27k). [swissprot;acc:p34062]	214.605	214.287	1.00148
2591	PBRM1	polybromo 1. [refseq;acc:nm_018165]	220.02	219.696	1.00147
2592	SMARCA5	swi/snf-related matrix-associated actin-dependent regulator of chromatin a5; sucrose nonfermenting-like 5. [refseq;acc:nm_003601]
2593	SMARCA4	possible global transcription activator snf2l4 (snf2-beta) (brg-1 protein) (mitotic growth and transcription activator) (brahma protein homolog 1). [swissprot;acc:p51532]
2594	SMARCA1	possible global transcription activator snf2l1. [swissprot;acc:p28370]
2595	BTAF1	tbp-associated factor 172 (taf-172) (taf(ii)170). [swissprot;acc:o14981]
2596	SMARCA2	possible global transcription activator snf2l2 (snf2-alpha). [swissprot;acc:p51531]
2597	IPO11	ran binding protein 11. [refseq;acc:nm_016338]	212.711	212.401	1.00146
2598	TAF5	transcription initiation factor tfiid 100 kda subunit (tafii-100) (tafii100). [swissprot;acc:q15542]	202.142	202.436	1.00145
2599	KIAA1432	ba207c16.2 (fragment). [sptrembl;acc:q9nql7]	211.662	211.361	1.00142
2600	HYAL3	interferon-related developmental regulator 2 (skmc15 protein). [swissprot;acc:q12894]	224.877	225.193	1.00141

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.