MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2532 to 2581 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Hugo	red	network_comparison	green
heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	Subtracted	408	HNRNPU	237.109	17.558	254.667
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	Divided	2021	COQ3	208.601	1.00893	210.464
	Subtracted				1.863
high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]	Divided	2989	no value	0.00001	1	0.00001
	Subtracted			0	0	0
high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6]	Divided	3144	HMG1L10	0.00001	1	0.00001
	Subtracted			0	0	0
high mobility group protein 2 (hmg-2). [swissprot;acc:p26583]	Divided	2856	HMGB2	0.00001	1	0.00001
	Subtracted			0	0	0
high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]	Divided	3203	HMGB3	0.00001	1	0.00001
	Subtracted			0	0	0
high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13]	Divided	2787	HMG4L	0.00001	1	0.00001
	Subtracted			0	0	0
high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083]	Divided	2876	PDE9A	0.00001	1	0.00001
	Subtracted			0	0	0
high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]	Divided	2863	no value	0.00001	1	0.00001
	Subtracted			0	0	0
high-mobility group 20a. [refseq;acc:nm_018200]	Divided	125	HMG20A	208.588	1.21429	171.778
	Subtracted	117			36.81
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	Divided	124	HMG20B	208.52	1.21519	171.595
	Subtracted	116			36.925
highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	Divided	440	NDC80	231.802	1.07843	249.983
	Subtracted	402			18.181
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Divided	788	NFU1	138.705	1.04653	132.538
	Subtracted	1055			6.167
histidine ammonia-lyase (ec 4.3.1.3) (histidase). [swissprot;acc:p42357]	Divided	2169	HAL	215.925	1.00673	214.481
	Subtracted	2145			1.444
histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	Divided	1715	HDC	206.549	1.01327	203.844
	Subtracted	1754			2.705
histidine-rich membrane protein ke4. [swissprot;acc:q92504]	Divided	2718	SLC39A7	216.52	1.00052	216.632
	Subtracted	2719			0.112
histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	Divided	1920	HARS	187.292	1.01013	185.413
	Subtracted	2018			1.879
histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	Divided	1919	HARS2	187.231	1.01015	185.349
	Subtracted	2017			1.882
histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	Divided	182	HAT1	277.546	1.15422	240.461
	Subtracted	115			37.085
histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	Divided	279	RBBP7	252.644	1.10605	228.42
	Subtracted	236			24.224
histone deacetylase 1 (hd1). [swissprot;acc:q13547]	Divided	777	HDAC1	225.989	1.04853	215.53
	Subtracted	745			10.459
histone deacetylase 11 (hd11). [swissprot;acc:q96db2]	Divided	2376	HDAC11	212.724	1.004	213.574
	Subtracted	2373			0.85
histone deacetylase 2 (hd2). [swissprot;acc:q92769]	Divided	775	no value	226.003	1.04854	215.541
	Subtracted	742			10.462
histone deacetylase 3 (hd3) (rpd3-2). [swissprot;acc:o15379]	Divided	2813	HDAC3	0.00001	1	0.00001
	Subtracted			0	0	0
histone deacetylase 4 (hd4). [swissprot;acc:p56524]	Divided	2424	HDAC4	220.682	1.00358	221.472
	Subtracted	2397			0.79
histone deacetylase 5 (hd5) (antigen ny-co-9). [swissprot;acc:q9uql6]	Divided	2423	HDAC5		1.00358	221.471

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.