MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2530 to 2579 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
heterogeneous nuclear ribonucleoproteins a2/b1 (hnrnp a2 / hnrnp b1). [swissprot;acc:p22626]	2134	HNRNPA2B1	Divided	221.248	222.788	1.00696
heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	408	HNRNPU	Subtracted	237.109	254.667	17.558
	482		Divided			1.07405
hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor (ec 2.1.1.114) (dihydroxyhexaprenylbenzoate methyltransferase) (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (dhhb methyltransferase) (dhhb-mt) (dhhb-mtase). [swissprot;acc:q9nzj6]	2021	COQ3		208.601	210.464	1.00893
			Subtracted			1.863
high mobility group protein 1 (hmg-1). [swissprot;acc:p09429]	2989	no value	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high mobility group protein 1-like 10 (hmg-1l10). [swissprot;acc:q9ugv6]	3144	HMG1L10	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high mobility group protein 2 (hmg-2). [swissprot;acc:p26583]	2856	HMGB2	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high mobility group protein 4 (hmg-4) (high mobility group protein 2a) (hmg-2a). [swissprot;acc:o15347]	3203	HMGB3	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high mobility group protein 4-like (hmg-4l). [swissprot;acc:q9uj13]	2787	HMG4L	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high-affinity cgmp-specific 3',5'-cyclic phosphodiesterase 9a (ec 3.1.4.17). [swissprot;acc:o76083]	2876	PDE9A	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high-glucose-regulated protein 8 (ny-ren-2 antigen). [swissprot;acc:q9y5a9]	2863	no value	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
high-mobility group 20a. [refseq;acc:nm_018200]	117	HMG20A		208.588	171.778	36.81
	125		Divided			1.21429
high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]	116	HMG20B	Subtracted	208.52	171.595	36.925
	124		Divided			1.21519
highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	402	NDC80	Subtracted	231.802	249.983	18.181
	440		Divided			1.07843
hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	788	NFU1		138.705	132.538	1.04653
	1055		Subtracted			6.167
histidine ammonia-lyase (ec 4.3.1.3) (histidase). [swissprot;acc:p42357]	2145	HAL		215.925	214.481	1.444
	2169		Divided			1.00673
histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	1715	HDC		206.549	203.844	1.01327
	1754		Subtracted			2.705
histidine-rich membrane protein ke4. [swissprot;acc:q92504]	2718	SLC39A7	Divided	216.52	216.632	1.00052
	2719		Subtracted			0.112
histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	1920	HARS	Divided	187.292	185.413	1.01013
	2018		Subtracted			1.879
histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	1919	HARS2	Divided	187.231	185.349	1.01015
	2017		Subtracted			1.882
histone acetyltransferase type b catalytic subunit (ec 2.3.1.48). [swissprot;acc:o14929]	115	HAT1		277.546	240.461	37.085
	182		Divided			1.15422
histone acetyltransferase type b subunit 2 (retinoblastoma binding protein p46) (retinoblastoma-binding protein 7) (rbbp-7). [swissprot;acc:q16576]	236	RBBP7	Subtracted	252.644	228.42	24.224
	279		Divided			1.10605
histone deacetylase 1 (hd1). [swissprot;acc:q13547]	745	HDAC1	Subtracted	225.989	215.53	10.459
	777		Divided			1.04853
histone deacetylase 11 (hd11). [swissprot;acc:q96db2]	2373	HDAC11	Subtracted	212.724	213.574	0.85
	2376		Divided			1.004
histone deacetylase 2 (hd2). [swissprot;acc:q92769]	742	no value	Subtracted	226.003	215.541	10.462
	775		Divided			1.04854
histone deacetylase 3 (hd3) (rpd3-2). [swissprot;acc:o15379]	2813	HDAC3		0.00001	0.00001	1
			Subtracted	0	0	0
histone deacetylase 4 (hd4). [swissprot;acc:p56524]	2397	HDAC4		220.682	221.472	0.79

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.