MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2520 to 2569 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
1260	protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]	COX10	Low confidence	199.952	195.538	1.02257
1261	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	DRD4	High confidence	219.354	224.7	1.02437
	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	no value	Low confidence	203.503	199.013	1.02256
1262	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	KATNB1		203.846	199.351	1.02255
	keratin associated protein 9.2. [refseq;acc:nm_031961]	KRTAP9-8	High confidence	219.353	224.678	1.02428
1263	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	MAPK11		171.231	167.177	1.02425
	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	SNW1	Low confidence	196.724	192.389	1.02253
1264	ras-related protein rab-11b (gtp-binding protein ypt3). [swissprot;acc:q15907]	RAB11B		203.934	199.445	1.02251
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	SPHK1	High confidence	171.231	167.177	1.02425
1265	kccr13l. [refseq;acc:nm_139179]	DAGLB	Low confidence	203.303	198.827	1.02251
	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	DPAGT1	High confidence	171.231	167.177	1.02425
1266	nadph:adrenodoxin oxidoreductase, mitochondrial precursor (ec 1.18.1.2) (adrenodoxin reductase) (ar) (ferredoxin-nadp(+) reductase). [swissprot;acc:p22570]	FDXR	Low confidence	201.264	196.834	1.02251
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	DLC1	High confidence	171.231	167.177	1.02425
1267	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	MAPKAPK2
	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	HIST1H2BA	Low confidence	203.672	199.189	1.02251
1268	histidyl-trna synthetase homolog (ec 6.1.1.21) (histidine--trna ligase homolog) (hisrs). [swissprot;acc:p49590]	HARS2		192.905	188.658
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	CHRNA6	High confidence	171.231	167.177	1.02425
1269	ectonucleoside triphosphate diphosphohydrolase 6 (ec 3.6.1.6) (ntpdase6) (cd39 antigen-like 2). [swissprot;acc:o75354]	no value	Low confidence	196.818	192.485	1.02251
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	ISCU	High confidence	171.231	167.177	1.02425
1270	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6	Low confidence	201.858	197.415	1.02251
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	STARD13	High confidence	171.231	167.177	1.02425
1271	histidyl-trna synthetase (ec 6.1.1.21) (histidine--trna ligase) (hisrs). [swissprot;acc:p12081]	HARS	Low confidence	192.956	188.71	1.0225
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	STARD8	High confidence	171.231	167.177	1.02425
1272	ceramide glucosyltransferase (ec 2.4.1.80) (glucosylceramide synthase) (gcs) (udp-glucose:n-acylsphingosine d-glucosyltransferase) (glct-1). [swissprot;acc:q16739]	UGCG	Low confidence	192.933	188.687	1.0225
	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	CHRNA2	High confidence	171.231	167.177	1.02425
1273	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	MAPKAPK3
	protein-tyrosine phosphatase, non-receptor type 2 (ec 3.1.3.48) (t- cell protein-tyrosine phosphatase) (tcptp). [swissprot;acc:p17706]	PTPN2	Low confidence	200.744	196.329	1.02249
1274	cryptochrome 1 (photolyase-like). [refseq;acc:nm_004075]	CRY1		193.539	189.282
	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	MAPK14	High confidence	171.231	167.177	1.02425
1275	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	HIST2H2BA	Low confidence	203.671	199.194	1.02248
	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	CHRNA4	High confidence	171.231	167.177	1.02425
1276	histone h2b. [refseq;acc:nm_175055]	no value	Low confidence	203.671	199.194	1.02248
	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	CHRNA3	High confidence	171.231	167.177	1.02425
1277	histone h2b.s (h2b/s). [swissprot;acc:p57053]	no value	Low confidence	203.671	199.194	1.02248
	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	SPHK2	High confidence	171.231	167.177	1.02425
1278	histone h2b.e (h2b/e). [swissprot;acc:q99879]	no value	Low confidence	203.671	199.194	1.02248
	sestrin 3. [swissprot;acc:p58005]	SESN3	High confidence	218.368	213.219	1.02415
1279	protein-tyrosine phosphatase, non-receptor type 1 (ec 3.1.3.48) (protein-tyrosine phosphatase 1b) (ptp-1b). [swissprot;acc:p18031]	no value	Low confidence	200.75	196.336	1.02248
	sestrin 2 (hi95). [swissprot;acc:p58004]	SESN2	High confidence	218.368	213.219	1.02415
1280	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	CYP4A11			213.22	1.02414
	histone h2b.c (h2b/c). [swissprot;acc:q99880]	HIST1H2BL	Low confidence	203.672	199.196	1.02247
1281	cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477]	CYP4F3	High confidence	218.368	213.22	1.02414
	histone h2b.d (h2b/d). [swissprot;acc:q99877]	no value	Low confidence	203.671	199.195	1.02247
1282	connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	CTGF		208.383	203.805	1.02246
	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	CYP4F8	High confidence	218.368	213.22	1.02414
1283	casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	no value	Low confidence	205.134	200.628	1.02246
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	CYP4X1	High confidence	218.368	213.22	1.02414
1284	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	CYP4F12
	fumarylacetoacetase (ec 3.7.1.2) (fumarylacetoacetate hydrolase) (beta-diketonase) (faa). [swissprot;acc:p16930]	FAH	Low confidence	202.294	197.852	1.02245
1285	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	CYP4F2	High confidence	218.368	213.22	1.02414

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.