MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2512 to 2561 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Interaction Map	red	network_comparison	green
628	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	MRRF	Subtracted	High confidence	229.072	12.496	216.576
629	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	GABRA3	Divided		214.256	1.05994	202.14
	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	no value	Subtracted	Low confidence	204.242	5.794	198.448
	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	PEX5		High confidence	229.072	12.496	216.576
	prolyl 4-hydroxylase alpha-1 subunit precursor (ec 1.14.11.2) (4-ph alpha-1) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit). [swissprot;acc:p13674]	P4HA1	Divided	Low confidence	204.369	1.02923	198.564
630	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	no value	Subtracted		204.242	5.794	198.448
	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	HEY2		High confidence	229.072	12.496	216.576
	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	NDUFA6	Divided		214.256	1.05993	202.141
	prolyl 4-hydroxylase alpha-2 subunit precursor (ec 1.14.11.2) (4-ph alpha-2) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit). [swissprot;acc:o15460]	P4HA2		Low confidence	204.369	1.02923	198.564
631	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	no value			204.242	1.0292	198.448
	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	PDXDC1		High confidence	214.256	1.05993	202.141
	similar to s. cerevisiae ssm4. [refseq;acc:nm_005885]	MARCH6	Subtracted	Low confidence	207.662	5.786	201.876
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	HES1		High confidence	229.072	12.496	216.576
632	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	ECH1
	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	no value	Divided	Low confidence	204.242	1.0292	198.448
	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	HOXD9		High confidence	214.254	1.05979	202.166
	large proline-rich protein bat3 (hla-b-associated transcript 3) (g3). [swissprot;acc:p46379]	no value	Subtracted	Low confidence	207.662	5.786	201.876
633	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]	ABLIM1		High confidence	229.072	12.496	216.576
	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	AARS	Divided		234.106	1.05979	248.104
	dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (ec 2.4.1.-) (dol-p-man dependent alpha(1-3)-mannosyltransferase) (not56-like protein). [swissprot;acc:q92685]	no value	Subtracted	Low confidence	200.085	5.784	194.301
	pp1201 protein. [refseq;acc:nm_022152]	TMBIM1	Divided		203.734	1.02919	197.956
634	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	no value		High confidence	226.523	1.05958	213.786
	pp1201 protein. [refseq;acc:nm_022152]	TMBIM1	Subtracted	Low confidence	203.734	5.778	197.956
	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	SYN1		High confidence	229.072	12.496	216.576
	tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	TSC22D4	Divided	Low confidence	203.726	1.02915	197.955
635	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	RPL37		High confidence	228.639	1.05957	242.258
	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]	BBS7		Low confidence	207.763	1.02913	201.882
	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	MVK	Subtracted	High confidence	235.296	12.377	247.673
	tsc22-related inducible leucine zipper protein 2 (tsc-22-like protein thg-1). [swissprot;acc:q9y3q8]	TSC22D4		Low confidence	203.726	5.771	197.955
636	probable rna-binding protein kiaa0682. [swissprot;acc:q9y4c8]	RBM19	Divided		206.001	1.02901	200.193
	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	N6AMT1	Subtracted		204.933	5.769	199.164
	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	SFRS1	Divided	High confidence	228.639	1.05957	242.258
	vav proto-oncogene. [swissprot;acc:p15498]	VAV1	Subtracted		212.2	12.351	199.849
637	1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (ec 2.3.1.51) (1- agp acyltransferase 3) (1-agpat 3) (lysophosphatidic acid acyltransferase-gamma) (lpaat-gamma) (1-acylglycerol-3-phosphate o- acyltransferase 3). [swissprot;acc:q9nrz7]	AGPAT3	Divided	Low confidence	192.166	1.029	186.751
	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	PPAT		High confidence	228.639	1.05957	242.258
	ba528a10.3.2 (novel protein similar to kiaa0161, isoform 2) (fragment). [sptrembl;acc:q9bx39]	RNF144B	Subtracted	Low confidence	208.62	5.765	202.855
	vav-3 protein. [swissprot;acc:q9ukw4]	VAV3		High confidence	212.253	12.345	199.908
638	nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]	NUFIP1	Divided	Low confidence	203.825	1.029	198.081
	sorting nexin 17. [swissprot;acc:q15036]	SNX17		High confidence	228.639	1.05957	242.258
	surfeit locus protein 1. [swissprot;acc:q15526]	SURF1	Subtracted	Low confidence	201.211	5.752	195.459
	vav-2 protein. [swissprot;acc:p52735]	VAV2		High confidence	212.526	12.314	200.212
639	nucleoporin-like protein rip (hiv-1 rev-binding protein) (rev interacting protein) (rev/rex activation domain-binding protein). [swissprot;acc:p52594]	HRB	Divided		217.67	1.05938	230.596
	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	N6AMT1		Low confidence	204.933	1.02897	199.164
	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	NOVA1	Subtracted	High confidence	222.554	12.293	234.847
	zinc finger protein 216. [swissprot;acc:o76080]	ZFAND5		Low confidence	184.361	5.748	178.613
640	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	no value		High confidence	244.842	12.265	232.577
	intersectin 1 (sh3 domain-containing protein 1a) (sh3p17). [swissprot;acc:q15811]		Divided		217.67	1.05938	230.596
	megf6 (fragment). [sptrembl;acc:o75095]	MEGF6		Low confidence	207.235	1.02896	201.402
	protein associated with prk1. [refseq;acc:nm_019006]	ZFAND6	Subtracted		184.361	5.748	178.613
641	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	no value		High confidence	244.842	12.265	232.577

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.