MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2508 to 2557 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
1254	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	G3BP1	Divided	219.354	1.02437	224.7
1255	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	CYP4A22	Subtracted	218.368	5.148	213.22
	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	G3BP2	Divided	219.354	1.02437	224.7
1256	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	CYP4B1	Subtracted	218.368	5.148	213.22
	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	no value	Divided	219.354	1.02437	224.699
1257	espin. [refseq;acc:nm_031475]	ESPNP				224.7
	flotillin-1. [swissprot;acc:o75955]	FLOT1	Subtracted	218.368	5.148	213.22
1258	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6	Divided	219.354	1.02437	224.7
	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	SESN1	Subtracted	218.368	5.148	213.22
1259	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	PLEKHC1	Divided	219.354	1.02437	224.7
	signal transducer and activator of transcription 5a. [swissprot;acc:p42229]	STAT5A	Subtracted	222.546	5.127	227.673
1260	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	LIMS2	Divided	219.354	1.02437	224.7
	signal transducer and activator of transcription 5b. [swissprot;acc:p51692]	STAT5B	Subtracted	222.544	5.123	227.667
1261	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	DRD4	Divided	219.354	1.02437	224.7
	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	CCT5	Subtracted	163.24	5.119	168.359
1262	keratin associated protein 9.2. [refseq;acc:nm_031961]	KRTAP9-8	Divided	219.353	1.02428	224.678
	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	DIMT1L	Subtracted	226.347	5.088	221.259
1263	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	MAPK11	Divided	171.231	1.02425	167.177
	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	PGAM4	Subtracted	212.724	5.087	207.637
1264	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	no value
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	SPHK1	Divided	171.231	1.02425	167.177
1265	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	PGAM2	Subtracted	212.724	5.087	207.637
	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	DPAGT1	Divided	171.231	1.02425	167.177
1266	mitochondrial processing peptidase beta subunit, mitochondrial precursor (ec 3.4.24.64) (beta-mpp) (p-52). [swissprot;acc:o75439]	PMPCB	Subtracted	217.635	5.06	212.575
	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	DLC1	Divided	171.231	1.02425	167.177
1267	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	MAPKAPK2
	mitochondrial processing peptidase alpha subunit, mitochondrial precursor (ec 3.4.24.64) (alpha-mpp) (p-55) (ha1523). [swissprot;acc:q10713]	PMPCA	Subtracted	217.634	5.058	212.576
1268	histone-lysine n-methyltransferase, h3 lysine-9 specific 2 (ec 2.1.1.43) (histone h3-k9 methyltransferase 2) (h3-k9-hmtase 2) (suppressor of variegation 3-9 homolog 2) (su(var)3-9 homolog 2). [swissprot;acc:q9h5i1]	SUV39H2		226.433		231.491
	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	CHRNA6	Divided	171.231	1.02425	167.177
1269	eukaryotic translation initiation factor 2 subunit 1 (eukaryotic translation initiation factor 2 alpha subunit) (eif-2-alpha) (eif- 2alpha) (eif-2a). [swissprot;acc:p05198]	EIF2S1	Subtracted	226.433	5.058	231.491
	nitrogen fixation cluster-like. [refseq;acc:nm_014301]	ISCU	Divided	171.231	1.02425	167.177
1270	histone-lysine n-methyltransferase, h3 lysine-9 specific 1 (ec 2.1.1.43) (histone h3-k9 methyltransferase 1) (h3-k9-hmtase 1) (suppressor of variegation 3-9 homolog 1) (su(var)3-9 homolog 1). [swissprot;acc:o43463]	SUV39H1	Subtracted	226.433	5.058	231.491
	star-related lipid transfer protein 13 (stard13) (start domain- containing protein 13) (46h23.2). [swissprot;acc:q9y3m8]	STARD13	Divided	171.231	1.02425	167.177
1271	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	EIF3C	Subtracted	245.532	5.049	240.483
	star-related lipid transfer protein 8 (stard8) (start domain- containing protein 8). [swissprot;acc:q92502]	STARD8	Divided	171.231	1.02425	167.177
1272	neuronal acetylcholine receptor protein, alpha-2 chain precursor. [swissprot;acc:q15822]	CHRNA2
	ubiquinol-cytochrome c reductase complex core protein i, mitochondrial precursor (ec 1.10.2.2). [swissprot;acc:p31930]	UQCRC1	Subtracted	217.624	5.04	212.584
1273	mitogen-activated protein kinase-activated protein kinase 3; mapkap kinase 3. [refseq;acc:nm_004635]	MAPKAPK3	Divided	171.231	1.02425	167.177
	serine/threonine protein phosphatase 2b catalytic subunit, alpha isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, alpha isoform) (cam-prp catalytic subunit). [swissprot;acc:q08209]	PPP3CA	Subtracted	218.439	5.003	213.436
1274	mitogen-activated protein kinase 14 (ec 2.7.1.37) (mitogen-activated protein kinase p38alpha) (map kinase p38alpha) (cytokine suppressive anti-inflammatory drug binding protein) (csaid binding protein) (csbp) (max-interacting protein 2) (map kinase mxi2) (sapk2a). [swissprot;acc:q16539]	MAPK14	Divided	171.231	1.02425	167.177
	p protein (melanocyte-specific transporter protein). [swissprot;acc:q04671]	OCA2	Subtracted	218.44	5.001	213.439
1275	neuronal acetylcholine receptor protein, alpha-4 chain precursor. [swissprot;acc:p43681]	CHRNA4	Divided	171.231	1.02425	167.177
	serine/threonine protein phosphatase 2b catalytic subunit, gamma isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, gamma isoform) (calcineurin, testis-specific catalytic subunit) (cam-prp catalytic subunit). [swissprot;acc:p48454]	PPP3CC	Subtracted	218.441	5	213.441
1276	neuronal acetylcholine receptor protein, alpha-3 chain precursor. [swissprot;acc:p32297]	CHRNA3	Divided	171.231	1.02425	167.177
	serine/threonine protein phosphatase 2b catalytic subunit, beta isoform (ec 3.1.3.16) (calmodulin-dependent calcineurin a subunit, beta isoform) (cam-prp catalytic subunit). [swissprot;acc:p16299]	PPP3CB	Subtracted	218.44	5	213.44
1277	dna polymerase epsilon p17 subunit (dna polymerase epsilon subunit 3) (chromatin accessibility complex 17) (huchrac17) (chrac-17). [swissprot;acc:q9nrf9]	POLE3		250.854	4.988	255.842
	sphingosine kinase 2 (ec 2.7.1.-) (sk 2) (spk 2). [swissprot;acc:q9nra0]	SPHK2	Divided	171.231	1.02425	167.177
1278	heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	NDST2	Subtracted	228.409	4.934	223.475
	sestrin 3. [swissprot;acc:p58005]	SESN3	Divided	218.368	1.02415	213.219
1279	n-deacetylase/n-sulfotransferase (heparan glucosaminyl) 3. [refseq;acc:nm_004784]	NDST3	Subtracted	228.409	4.934	223.475

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.