MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2482 to 2531 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1241	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor). [swissprot;acc:p40763]	Subtracted	222.573	227.75	5.177
1242	no value	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Divided	219.354	224.7	1.02437
	RALGDS	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Subtracted	162.055	156.884	5.171
1243	no value	keratin associated protein 1.5. [refseq;acc:nm_031957]	Divided	219.354	224.699	1.02437
	STAT6	signal transducer and activator of transcription 6 (il-4 stat). [swissprot;acc:p42226]	Subtracted	222.569	227.739	5.17
1244	STARD6	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Divided	219.354	224.7	1.02437
	TPD52L1	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	Subtracted	206.774	211.936	5.162
1245	KRTAP5-8	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	Divided	219.354	224.699	1.02437
	TPD52	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	Subtracted	206.771	211.926	5.155
1246	no value	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Divided	219.354	224.699	1.02437
	SESN3	sestrin 3. [swissprot;acc:p58005]	Subtracted	218.368	213.219	5.149
1247	SESN2	sestrin 2 (hi95). [swissprot;acc:p58004]
	STARD5	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Divided	219.354	224.7	1.02437
1248	CYP4A11	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	Subtracted	218.368	213.22	5.148
	KRTAP4-4	keratin associated protein 4.4. [refseq;acc:nm_032524]	Divided	219.354	224.699	1.02437
1249	no value	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]			224.7
	CYP4F3	cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477]	Subtracted	218.368	213.22	5.148
1250	CYP4F8	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]
	LIMS1	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	Divided	219.354	224.7	1.02437
1251	CYP4X1	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Subtracted	218.368	213.22	5.148
	ILK	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]	Divided	219.354	224.7	1.02437
1252	CYP4F12	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Subtracted	218.368	213.22	5.148
	STARD4	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	Divided	219.354	224.7	1.02437
1253	CYP4F2	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	Subtracted	218.368	213.22	5.148
	RSU1	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	Divided	219.354	224.7	1.02437
1254	CYP4F11	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	Subtracted	218.368	213.22	5.148
	G3BP1	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Divided	219.354	224.7	1.02437
1255	CYP4A22	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	Subtracted	218.368	213.22	5.148
	G3BP2	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	Divided	219.354	224.7	1.02437
1256	no value	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]			224.699
	CYP4B1	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	Subtracted	218.368	213.22	5.148
1257	ESPNP	espin. [refseq;acc:nm_031475]	Divided	219.354	224.7	1.02437
	FLOT1	flotillin-1. [swissprot;acc:o75955]	Subtracted	218.368	213.22	5.148
1258	CYP2D6	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	Divided	219.354	224.7	1.02437
	SESN1	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	Subtracted	218.368	213.22	5.148
1259	PLEKHC1	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	Divided	219.354	224.7	1.02437
	STAT5A	signal transducer and activator of transcription 5a. [swissprot;acc:p42229]	Subtracted	222.546	227.673	5.127
1260	LIMS2	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	Divided	219.354	224.7	1.02437
	STAT5B	signal transducer and activator of transcription 5b. [swissprot;acc:p51692]	Subtracted	222.544	227.667	5.123
1261	CCT5	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]		163.24	168.359	5.119
	DRD4	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	Divided	219.354	224.7	1.02437
1262	DIMT1L	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	Subtracted	226.347	221.259	5.088
	KRTAP9-8	keratin associated protein 9.2. [refseq;acc:nm_031961]	Divided	219.353	224.678	1.02428
1263	MAPK11	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]		171.231	167.177	1.02425
	PGAM4	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Subtracted	212.724	207.637	5.087
1264	no value	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]
	SPHK1	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Divided	171.231	167.177	1.02425
1265	DPAGT1	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]
	PGAM2	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Subtracted	212.724	207.637	5.087
1266	DLC1	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	Divided	171.231	167.177	1.02425

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.