MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2482 to 2531 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	red	network_comparison	green
heparan sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.8) (n-hsst) (hsnst) ([heparan sulfate]-glucosamine n-sulfotransferase) (n-heparan sulfate sulfotransferase) (glucosaminyl n-deacetylase/n- sulfotransferase). [swissprot;acc:p52848]	1356	Divided	NDST1	228.409	1.02208	223.475
heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	1278	Subtracted	NDST2		4.934
	1353	Divided			1.02208
hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	2488		no value	194.527	1.00284	195.08
	2499	Subtracted			0.553
hepatocellular carcinoma susceptibility protein; x 003 protein; hdcmc29p; hspc260; likely ortholog of mouse cd40 ligand-activated specific transcript 3 (clast3). [refseq;acc:nm_020232]	2376		TNFSF5IP1	212.724	0.85	213.574
	2379	Divided			1.004
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	88		no value	88.2482	1.24949	110.265
	306	Subtracted			22.0168
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	84	Divided	MAGEE2		1.24949
	302	Subtracted			22.0168
hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	2749	Divided	HGS	190.522	1.00014	190.496
		Subtracted			0.026
hepatocyte nuclear factor 3-alpha (hnf-3a) (forkhead box protein a1). [swissprot;acc:p55317]	1597		FOXA1	217.322	3.406	213.916
	1605	Divided			1.01592
hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1602	Subtracted	FOXA2	217.233	3.336	213.897
	1614	Divided			1.0156
hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	1519	Subtracted	FOXA3	217.785	3.764	214.021
	1528	Divided			1.01759
hepatocyte nuclear factor 4-alpha (hnf-4-alpha) (transcription factor hnf-4) (transcription factor 14). [swissprot;acc:p41235]	996	Subtracted	HNF4A	251.863	6.966	258.829
	1115	Divided			1.02766
hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	993	Subtracted	HNF4G		6.966
	1112	Divided			1.02766
hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	784	Subtracted	HDGF	231.734	9.512	222.222
	835	Divided			1.0428
hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	780	Subtracted	no value		9.512
	831	Divided			1.0428
heterogeneous nuclear ribonucleoprotein a1 (helix-destabilizing protein) (single-strand binding protein) (hnrnp core protein a1). [swissprot;acc:p09651]	2111	Subtracted	HNRNPA1	221.248	1.54	222.788
	2129	Divided			1.00696
heterogeneous nuclear ribonucleoprotein a3 (hnrnp a3) (d10s102). [swissprot;acc:p51991]	2104	Subtracted	HNRPA3		1.54
	2121	Divided			1.00696
heterogeneous nuclear ribonucleoprotein f (hnrnp f). [swissprot;acc:p52597]	1849	Subtracted	HNRPF	217.893	2.348	215.545
	1858	Divided			1.01089
heterogeneous nuclear ribonucleoprotein h (hnrnp h). [swissprot;acc:p31943]	1850	Subtracted	HNRPH1	217.895	2.348	215.547
	1859	Divided			1.01089
heterogeneous nuclear ribonucleoprotein h' (hnrnp h') (ftp-3). [swissprot;acc:p55795]	1851	Subtracted	HNRPH2		2.348
	1860	Divided			1.01089
heterogeneous nuclear ribonucleoprotein h3 (hnrnp h3) (hnrnp 2h9). [swissprot;acc:p31942]	1848	Subtracted	HNRPH3	217.892	2.349	215.543
	1856	Divided			1.0109
heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	835	Subtracted	HNRPK	224.413	8.859	233.272
	872	Divided			1.03948
heterogeneous nuclear ribonucleoprotein l (hnrnp l). [swissprot;acc:p14866]	1041		HNRNPL	186.774	1.03134	181.099
	1122	Subtracted			5.675
heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	292		HNRPM	234.146	22.481	256.627
	367	Divided			1.09601
heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	213	Subtracted	HNRNPR	237.302	24.892	212.41
	250	Divided			1.11719
heterogeneous nuclear ribonucleoproteins a2/b1 (hnrnp a2 / hnrnp b1). [swissprot;acc:p22626]	2114	Subtracted	HNRNPA2B1	221.248	1.54	222.788
	2134	Divided			1.00696
heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	408	Subtracted	HNRNPU	237.109	17.558	254.667

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.