MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Value Type	Hugo	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2475 to 2524 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
619	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Subtracted	VPS39	High confidence	206.274	218.792	12.518
	wd repeat and fyve domain containing 3 isoform 1. [refseq;acc:nm_014991]	Divided	WDFY3	Low confidence	205.129	199.271	1.0294
620	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]		GABRG1	High confidence	214.256	202.14	1.05994
	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Subtracted	MAP4		206.274	218.792	12.518
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	Divided	no value	Low confidence	203.68	197.868	1.02937
		Subtracted					5.812
621	60s acidic ribosomal protein p2. [swissprot;acc:p05387]		RPLP2	High confidence	231.92	244.435	12.515
	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Divided	GABRA2		214.256	202.14	1.05994
	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]		SREBF1	Low confidence	203.68	197.868	1.02937
		Subtracted					5.812
622	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	Divided	GABRA6	High confidence	214.256	202.14	1.05994
	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]		GRB2	Low confidence	204.479	198.65	1.02934
	probable rna-binding protein kiaa0682. [swissprot;acc:q9y4c8]	Subtracted	RBM19		206.001	200.193	5.808
	synapsin iii. [swissprot;acc:o14994]		SYN3	High confidence	229.072	216.576	12.496
623	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]		no value
	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Divided	GABRG2		214.256	202.14	1.05994
	jumonji protein. [swissprot;acc:q92833]		JARID2	Low confidence	207.726	201.813	1.0293
	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]	Subtracted	P4HB		204.369	198.564	5.805
624	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]		HEY1	High confidence	229.072	216.576	12.496
	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	Divided	no value		214.256	202.139	1.05994
	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]		NHP2L1	Low confidence	205.16	199.322	1.02929
	prolyl 4-hydroxylase alpha-1 subunit precursor (ec 1.14.11.2) (4-ph alpha-1) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit). [swissprot;acc:p13674]	Subtracted	P4HA1		204.369	198.564	5.805
625	actin binding lim protein 2. [refseq;acc:nm_032432]		ABLIM2	High confidence	229.072	216.576	12.496
	cullin homolog 1 (cul-1). [swissprot;acc:q13616]	Divided	CUL1	Low confidence	203.853	198.057	1.02926
	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]		GABRA4	High confidence	214.256	202.14	1.05994
	prolyl 4-hydroxylase alpha-2 subunit precursor (ec 1.14.11.2) (4-ph alpha-2) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit). [swissprot;acc:o15460]	Subtracted	P4HA2	Low confidence	204.369	198.564	5.805
626	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	Divided	GABRE	High confidence	214.256	202.14	1.05994
	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	Subtracted	HEYL		229.072	216.576	12.496
	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	Divided	HIST3H3	Low confidence	204.239	198.436	1.02924
		Subtracted					5.803
627	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]		no value		204.234	198.433	5.801
	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Divided	JMJD6	High confidence	214.256	202.139	1.05994
	protein disulfide isomerase precursor (pdi) (ec 5.3.4.1) (prolyl 4- hydroxylase beta subunit) (cellular thyroid hormone binding protein) (p55). [swissprot;acc:p07237]		P4HB	Low confidence	204.369	198.564	1.02923
	synapsin ii. [swissprot;acc:q92777]	Subtracted	SYN2	High confidence	229.072	216.576	12.496
628	cullin homolog 1 (cul-1). [swissprot;acc:q13616]		CUL1	Low confidence	203.853	198.057	5.796
	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Divided	GABRA1	High confidence	214.256	202.14	1.05994
	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]		no value	Low confidence	204.234	198.433	1.02923
	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	Subtracted	MRRF	High confidence	229.072	216.576	12.496
629	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Divided	GABRA3		214.256	202.14	1.05994
	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	Subtracted	no value	Low confidence	204.242	198.448	5.794
	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]		PEX5	High confidence	229.072	216.576	12.496
	prolyl 4-hydroxylase alpha-1 subunit precursor (ec 1.14.11.2) (4-ph alpha-1) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit). [swissprot;acc:p13674]	Divided	P4HA1	Low confidence	204.369	198.564	1.02923
630	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Subtracted	no value		204.242	198.448	5.794
	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]		HEY2	High confidence	229.072	216.576	12.496
	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Divided	NDUFA6		214.256	202.141	1.05993
	prolyl 4-hydroxylase alpha-2 subunit precursor (ec 1.14.11.2) (4-ph alpha-2) (procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit). [swissprot;acc:o15460]		P4HA2	Low confidence	204.369	198.564	1.02923
631	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]		no value		204.242	198.448	1.0292
	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]		PDXDC1	High confidence	214.256	202.141	1.05993
	similar to s. cerevisiae ssm4. [refseq;acc:nm_005885]	Subtracted	MARCH6	Low confidence	207.662	201.876	5.786
	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]		HES1	High confidence	229.072	216.576	12.496

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.