MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2475 to 2524 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1238	no value	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	Low confidence	202.15	197.664	1.0227
		keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	High confidence	219.354	224.699	1.02437
1239		keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
		[pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (ec 3.1.3.43) (pdp 2) (pyruvate dehydrogenase phosphatase, catalytic subunit 2) (pdpc 2). [swissprot;acc:q9p2j9]	Low confidence	202.786	198.286	1.02269
1240		dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388]		201.458	196.99	1.02268
		keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	High confidence	219.354	224.7	1.02437
1241		keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
	TOP2B	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	Low confidence	201.449	196.981	1.02268
1242	no value	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	High confidence	219.354	224.7	1.02437
	KCTD13	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	Low confidence	204.227	199.699	1.02267
1243	no value	keratin associated protein 1.5. [refseq;acc:nm_031957]	High confidence	219.354	224.699	1.02437
	TNFAIP1	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	Low confidence	204.228	199.7	1.02267
1244	PI4K2A	phosphatidylinositol 4-kinase type ii. [refseq;acc:nm_018425]		198.639	194.235
	STARD6	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	High confidence	219.354	224.7	1.02437
1245	KRTAP5-8	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]			224.699
	PROSC	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Low confidence	200.278	195.84	1.02266
1246	no value	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	High confidence	219.354	224.699	1.02437
	PPM2C	[pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (ec 3.1.3.43) (pdp 1) (pyruvate dehydrogenase phosphatase, catalytic subunit 1) (pdpc 1). [swissprot;acc:q9p0j1]	Low confidence	202.791	198.299	1.02265
1247	CNOT8	ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]		202.14	197.663
	STARD5	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	High confidence	219.354	224.7	1.02437
1248	KRTAP4-4	keratin associated protein 4.4. [refseq;acc:nm_032524]			224.699
	MCM5	dna replication licensing factor mcm5 (cdc46 homolog) (p1-cdc46). [swissprot;acc:p33992]	Low confidence	202.294	197.813	1.02265
1249	no value	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	High confidence	219.354	224.7	1.02437
	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Low confidence	202.087	197.614	1.02264
1250	HAAO	3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]		180.665	176.667	1.02263
	LIMS1	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	High confidence	219.354	224.7	1.02437
1251	ILK	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
	ZIC2	zinc finger protein zic 2 (zinc finger protein of the cerebellum 2). [swissprot;acc:o95409]	Low confidence	204.937	200.402	1.02263
1252	ELAVL2	elav-like protein 2 (hu-antigen b) (hub) (elav-like neuronal protein 1) (nervous system-specific rna binding protein hel-n1). [swissprot;acc:q12926]		202.261	197.788	1.02262
	STARD4	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	High confidence	219.354	224.7	1.02437
1253	RSU1	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]
	STX18	syntaxin 18. [swissprot;acc:q9p2w9]	Low confidence	204.026	199.515	1.02261
1254	AIG1	androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]
	G3BP1	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	High confidence	219.354	224.7	1.02437
1255	G3BP2	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]
	PBLD	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	Low confidence	185.205	181.112	1.0226
1256	no value	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	High confidence	219.354	224.699	1.02437
	ACVR1B	serine/threonine-protein kinase receptor r2 precursor (ec 2.7.1.37) (skr2) (activin receptor-like kinase 4) (alk-4) (actr-ib). [swissprot;acc:p36896]	Low confidence	204.05	199.543	1.02259
1257	ACVR1C	activin a receptor, type ic; activin receptor-like kinase 7. [refseq;acc:nm_145259]
	ESPNP	espin. [refseq;acc:nm_031475]	High confidence	219.354	224.7	1.02437
1258	CYP2D6	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]
	TGFBR1	tgf-beta receptor type i precursor (ec 2.7.1.37) (tgfr-1) (tgf-beta type i receptor) (serine/threonine-protein kinase receptor r4) (skr4) (activin receptor-like kinase 5) (alk-5). [swissprot;acc:p36897]	Low confidence	204.05	199.545	1.02258
1259	PIGZ	smp3 mannosyltransferase. [refseq;acc:nm_025163]		202.715	198.24	1.02257
	PLEKHC1	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	High confidence	219.354	224.7	1.02437
1260	COX10	protoheme ix farnesyltransferase, mitochondrial precursor (ec 2.5.1.-) (heme o synthase). [swissprot;acc:q12887]	Low confidence	199.952	195.538	1.02257
	LIMS2	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	High confidence	219.354	224.7	1.02437
1261	no value	succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial precursor (cybs) (succinate-ubiquinone reductase membrane anchor subunit) (qps2) (cii-4) (succinate dehydrogenase complex subunit d) (succinate-ubiquinone oxidoreductase cytochrome b small subunit). [swissprot;acc:o14521]	Low confidence	203.503	199.013	1.02256
	DRD4	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	High confidence	219.354	224.7	1.02437
1262	KATNB1	katanin p80 subunit b 1; katanin (80 kda); katanin p80 (wd40-containing) subunit b 1. [refseq;acc:nm_005886]	Low confidence	203.846	199.351	1.02255
	KRTAP9-8	keratin associated protein 9.2. [refseq;acc:nm_031961]	High confidence	219.353	224.678	1.02428

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.