MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 247 to 296 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	325	MRPL13	Subtracted	241.828	263.62	21.792
	390		Divided			1.09011
60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	327	RPL13A	Subtracted	241.83	263.615	21.785
	392		Divided			1.09008
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	222	no value	Subtracted	242.153	266.673	24.52
	306		Divided			1.10126
60s ribosomal protein l15. [swissprot;acc:p39030]	577	RPL15	Subtracted	217.862	230.978	13.116
	604		Divided			1.0602
60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	200	no value	Subtracted	241.808	267.335	25.527
	281		Divided			1.10557
60s ribosomal protein l18. [swissprot;acc:q07020]	411	RPL18	Subtracted	237.109	254.667	17.558
	485		Divided			1.07405
60s ribosomal protein l18a. [swissprot;acc:q02543]	819	no value	Subtracted	234.025	224.958	9.067
	860		Divided			1.04031
60s ribosomal protein l19. [swissprot;acc:p14118]	245	RPL19	Subtracted	240.73	264.729	23.999
	319		Divided			1.09969
60s ribosomal protein l21. [swissprot;acc:p46778]	1019	no value	Subtracted	223.958	217.263	6.695
	1054		Divided			1.03082
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]	2205			199.129	200.413	1.00645
	2229		Subtracted			1.284
60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	208			240.782	265.717	24.935
	293		Divided			1.10356
60s ribosomal protein l23a. [swissprot;acc:p29316]	243		Subtracted	241.884	265.945	24.061
	323		Divided			1.09947
60s ribosomal protein l24 (l30). [swissprot;acc:p38663]	1767	RPL24		201.288	198.86	1.01221
	1821		Subtracted			2.428
60s ribosomal protein l26. [swissprot;acc:q02877]	217	RPL26		242.326	267.008	24.682
	302		Divided			1.10185
60s ribosomal protein l28. [swissprot;acc:p46779]	1868	RPL28	Subtracted	215.896	213.61	2.286
	1882		Divided			1.0107
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	2664	RPL29		204.768	204.549	1.00107
	2668		Subtracted			0.219
60s ribosomal protein l3-like. [swissprot;acc:q92901]	229	RPL3L		242.195	266.663	24.468
	312		Divided			1.10103
60s ribosomal protein l30. [swissprot;acc:p04645]	286	RPL30	Subtracted	242.593	265.365	22.772
	378		Divided			1.09387
60s ribosomal protein l31. [swissprot;acc:p12947]	821	RPL31	Subtracted	234.025	224.958	9.067
	862		Divided			1.04031
60s ribosomal protein l32. [swissprot;acc:p02433]	197	SNORA7A	Subtracted	241.13	266.969	25.839
	276		Divided			1.10716
60s ribosomal protein l34, mitochondrial precursor (l34mt). [swissprot;acc:q9bq48]	1296	MRPL34	Subtracted	220.681	215.78	4.901
	1333		Divided			1.02271
60s ribosomal protein l34. [swissprot;acc:p49207]	224	RPL34	Subtracted	242.153	266.673	24.52
	308		Divided			1.10126
60s ribosomal protein l35. [swissprot;acc:p42766]	218	RPL35	Subtracted	242.333	266.999	24.666
	303		Divided			1.10179
60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	274	MRPL36	Subtracted	242.744	266.07	23.326
	365		Divided			1.09609
60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]	567	RPL37	Subtracted	228.639	242.258	13.619
	635		Divided			1.05957

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.