MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1226	ATP1A1	sodium/potassium-transporting atpase alpha-1 chain precursor (ec 3.6.3.9) (sodium pump 1) (na+/k+ atpase 1). [swissprot;acc:p05023]	Low confidence	203.499	198.964	1.02279
	UBE2E4P	ubiquitin-conjugating enzyme e2e 3; ubiquitin carrier protein; ubiquitin-protein ligase. [refseq;acc:nm_006357]	High confidence	166.846	170.989	1.02483
1227	ATP1A2	sodium/potassium-transporting atpase alpha-2 chain precursor (ec 3.6.3.9) (sodium pump 2) (na+/k+ atpase 2). [swissprot;acc:p50993]	Low confidence	203.499	198.964	1.02279
	PYCR2	pyrroline 5-carboxylate reductase isoform. [refseq;acc:nm_013328]	High confidence	172.365	168.219	1.02465
1228	CALML3	calmodulin-related protein nb-1 (calmodulin-like protein) (clp). [swissprot;acc:p27482]	Low confidence	201.109	196.63	1.02278
	GCLM	glutamate--cysteine ligase regulatory subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs light chain) (glutamate--cysteine ligase modifier subunit). [swissprot;acc:p48507]	High confidence	213.079	218.325	1.02462
1229	ARF1	adp-ribosylation factor 1. [swissprot;acc:p32889]	Low confidence	202.83	198.315	1.02277
	GCLC	glutamate--cysteine ligase catalytic subunit (ec 6.3.2.2) (gamma- glutamylcysteine synthetase) (gamma-ecs) (gcs heavy chain). [swissprot;acc:p48506]	High confidence	213.079	218.325	1.02462
1230	IL4I1	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]		219.55	214.288	1.02456
	ZIC3	zinc finger protein zic 3 (zinc finger protein of the cerebellum 3). [swissprot;acc:o60481]	Low confidence	204.929	200.371	1.02275
1231	PGAM4	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	High confidence	212.724	207.637	1.0245
	TOMM22	mitochondrial import receptor subunit tom22 homolog (translocase of outer membrane 22 kda subunit homolog) (htom22) (1c9-2). [swissprot;acc:q9ns69]	Low confidence	202.8	198.291	1.02274
1232	PYCR1	pyrroline-5-carboxylate reductase (ec 1.5.1.2) (p5cr) (p5c reductase). [swissprot;acc:p32322]	High confidence	172.543	168.417	1.0245
	RAD51	dna repair protein rad51 homolog 1 (hrad51) (hsrad51). [swissprot;acc:q06609]	Low confidence	200.818	196.355	1.02273
1233	no value	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]	High confidence	212.724	207.637	1.0245
	ZIC1	zinc finger protein zic 1 (zinc finger protein of the cerebellum 1). [swissprot;acc:q15915]	Low confidence	204.913	200.361	1.02272
1234	PGAM2	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	High confidence	212.724	207.637	1.0245
	TIPRL	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	Low confidence	194.777	199.203	1.02272
1235	no value	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	High confidence	219.356	224.723	1.02447
	WIPF1	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Low confidence	199.238	194.813	1.02271
1236	no value	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	High confidence	219.354	224.699	1.02437
	KCTD10	mstp028 protein. [refseq;acc:nm_031954]	Low confidence	204.242	199.707	1.02271
1237	no value	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	High confidence	219.354	224.699	1.02437
	PI4K2B	phosphatidylinositol 4-kinase type-ii beta; likely ortholog of mouse phosphatidylinositol 4-kinase type 2 beta. [refseq;acc:nm_018323]	Low confidence	198.635	194.227	1.0227
1238	no value	ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]		202.15	197.664
		keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	High confidence	219.354	224.699	1.02437
1239		keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
		[pyruvate dehydrogenase [lipoamide]]-phosphatase 2, mitochondrial precursor (ec 3.1.3.43) (pdp 2) (pyruvate dehydrogenase phosphatase, catalytic subunit 2) (pdpc 2). [swissprot;acc:q9p2j9]	Low confidence	202.786	198.286	1.02269
1240		dna topoisomerase ii, alpha isozyme (ec 5.99.1.3). [swissprot;acc:p11388]		201.458	196.99	1.02268
		keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	High confidence	219.354	224.7	1.02437
1241		keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]
	TOP2B	dna topoisomerase ii, beta isozyme (ec 5.99.1.3). [swissprot;acc:q02880]	Low confidence	201.449	196.981	1.02268
1242	no value	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	High confidence	219.354	224.7	1.02437
	KCTD13	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	Low confidence	204.227	199.699	1.02267
1243	no value	keratin associated protein 1.5. [refseq;acc:nm_031957]	High confidence	219.354	224.699	1.02437
	TNFAIP1	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	Low confidence	204.228	199.7	1.02267
1244	PI4K2A	phosphatidylinositol 4-kinase type ii. [refseq;acc:nm_018425]		198.639	194.235
	STARD6	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	High confidence	219.354	224.7	1.02437
1245	KRTAP5-8	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]			224.699
	PROSC	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	Low confidence	200.278	195.84	1.02266
1246	no value	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	High confidence	219.354	224.699	1.02437
	PPM2C	[pyruvate dehydrogenase [lipoamide]]-phosphatase 1, mitochondrial precursor (ec 3.1.3.43) (pdp 1) (pyruvate dehydrogenase phosphatase, catalytic subunit 1) (pdpc 1). [swissprot;acc:q9p0j1]	Low confidence	202.791	198.299	1.02265
1247	CNOT8	ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]		202.14	197.663
	STARD5	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	High confidence	219.354	224.7	1.02437
1248	KRTAP4-4	keratin associated protein 4.4. [refseq;acc:nm_032524]			224.699
	MCM5	dna replication licensing factor mcm5 (cdc46 homolog) (p1-cdc46). [swissprot;acc:p33992]	Low confidence	202.294	197.813	1.02265
1249	no value	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	High confidence	219.354	224.7	1.02437
	MDN1	midasin (midas-containing protein). [swissprot;acc:q9nu22]	Low confidence	202.087	197.614	1.02264
1250	HAAO	3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]		180.665	176.667	1.02263
	LIMS1	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	High confidence	219.354	224.7	1.02437

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.