MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2451 to 2500 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	green	network_comparison
heat shock factor binding protein 1. [swissprot;acc:o75506]	1598	no value	Subtracted	216.62	213.22	3.4
	1603		Divided			1.01595
heat shock protein hsp 90-alpha (hsp 86). [swissprot;acc:p07900]	2735	HSP90AA2		220.943	220.887	1.00025
			Subtracted			0.056
heat shock protein hsp 90-beta (hsp 84) (hsp 90). [swissprot;acc:p08238]	2724	HSP90AB1	Divided	221.053	220.963	1.00041
			Subtracted			0.09
heat shock-related 70 kda protein 2 (heat shock 70 kda protein 2). [swissprot;acc:p54652]	2178	HSPA2	Divided	210.961	209.563	1.00667
	2183		Subtracted			1.398
heat-shock 20 kda like-protein p20. [swissprot;acc:o14558]	3225	HSPB6	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
heat-shock protein, beta-2 (hspb2) (dmpk-binding protein) (mkbp). [swissprot;acc:q16082]	2824	HSPB2	Divided	0.00001	0.00001	1
			Subtracted	0	0	0
hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]	503	HECTD1		237.28	252.492	15.212
	586		Divided			1.06411
hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	1140	HECW1	Subtracted	219.399	213.784	5.615
	1171		Divided			1.02626
helicase (fragment). [sptrembl;acc:q92771]	1719	no value		187.204	189.679	1.01322
	1799		Subtracted			2.475
hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	735	HEMK1		229.045	218.343	10.702
	765		Divided			1.04901
heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	1485	HS6ST2	Subtracted	228.419	232.376	3.957
	1534		Divided			1.01732
heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	1486	HS6ST1	Subtracted			3.957
	1535		Divided			1.01732
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 2; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006043]	263	HS3ST2		219.421	196.978	1.11394
	296		Subtracted			22.443
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3a1; heparin-glucosamine 3-o-sulfotransferase. [refseq;acc:nm_006042]	261	HS3ST3A1	Divided			1.11394
	294		Subtracted			22.443
heparan sulfate d-glucosaminyl 3-o-sulfotransferase 3b1. [refseq;acc:nm_006041]	262	HS3ST3B1	Divided			1.11394
	295		Subtracted			22.443
heparan sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.8) (n-hsst) (hsnst) ([heparan sulfate]-glucosamine n-sulfotransferase) (n-heparan sulfate sulfotransferase) (glucosaminyl n-deacetylase/n- sulfotransferase). [swissprot;acc:p52848]	1281	NDST1		228.409	223.475	4.934
	1356		Divided			1.02208
heparin sulfate n-deacetylase/n-sulfotransferase (ec 2.8.2.-) (n- hsst) (n-heparin sulfate sulfotransferase) (glucosaminyl n- deacetylase/n-sulfotransferase). [swissprot;acc:p52849]	1278	NDST2	Subtracted			4.934
	1353		Divided			1.02208
hepatitis c virus core-binding protein 6; cervical cancer oncogene 3. [refseq;acc:nm_023934]	2488	no value		194.527	195.08	1.00284
	2499		Subtracted			0.553
hepatocellular carcinoma susceptibility protein; x 003 protein; hdcmc29p; hspc260; likely ortholog of mouse cd40 ligand-activated specific transcript 3 (clast3). [refseq;acc:nm_020232]	2376	TNFSF5IP1		212.724	213.574	0.85
	2379		Divided			1.004
hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	88	no value		88.2482	110.265	1.24949
	306		Subtracted			22.0168
hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	84	MAGEE2	Divided			1.24949
	302		Subtracted			22.0168
hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	2749	HGS	Divided	190.522	190.496	1.00014
			Subtracted			0.026
hepatocyte nuclear factor 3-alpha (hnf-3a) (forkhead box protein a1). [swissprot;acc:p55317]	1597	FOXA1		217.322	213.916	3.406
	1605		Divided			1.01592
hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	1602	FOXA2	Subtracted	217.233	213.897	3.336
	1614		Divided			1.0156
hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	1519	FOXA3	Subtracted	217.785	214.021	3.764
	1528		Divided			1.01759

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.