MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

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Showing element 244 to 293 of 66312 in total

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description	Rank	Network Comparison Type	Value Type	Hugo	Interaction Map	red	green	network_comparison
16.7kd protein. [refseq;acc:nm_016139]	3341	Subtracted	Ranked	CHCHD2	Low confidence	198.949	195.864	3.085
	3532		Rooted			73.4106	75.5801	2.1695
	3651	Divided						1.02955
	3907	Subtracted	Measured			8297.71	8483.17	185.46
	4005	Divided						1.02235
17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	975	Subtracted		no value		8189.31	8498.04	308.73
	1029		Ranked		High confidence	211.449	217.998	6.549
	1051	Divided	Measured		Low confidence	8189.31	8498.04	1.0377
			Ranked		High confidence	211.449	217.998	1.03097
	1278	Subtracted	Rooted		Low confidence	72.9975	75.6999	2.7024
	1381	Divided						1.03702
	1803		Ranked			199.592	195.655	1.02012
	1836	Subtracted						3.937
	2200		Squared		High confidence	25809.5	27574.1	1764.6
	2377	Divided						1.06837
	2496	Subtracted	Measured			5964.17	6113.96	149.79
	2521	Divided						1.02511
	2633	Subtracted	Rooted			63.9773	63.5847	0.3926
	2642	Divided						1.00617
	4634	Subtracted	Squared		Low confidence	46495	45738.2	756.8
	4655	Divided						1.01655
17-beta-hydroxysteroid dehydrogenase type vii-like. [refseq;acc:nm_182829]	562	Subtracted	Measured	HSD17B7P2		8316.12	8689.28	373.16
	631	Divided						1.04487
	963	Subtracted	Rooted			74.1433	76.9933	2.85
	1116	Divided						1.03844
	2142		Ranked			196.577	192.884	1.01915
	2279	Subtracted						3.693
	4920		Squared			46142.7	45903.5	239.2
	4933	Divided						1.00521
2,4-dienoyl coa reductase 2, peroxisomal; peroxisomal 2,4-dienoyl-coa reductase. [refseq;acc:nm_020664]	446	Subtracted		DECR2		48116.9	45146.7	2970.2
	447	Divided						1.06579
	3842	Subtracted	Ranked			201.014	198.422	2.592
	3846	Divided						1.01306
	3986	Subtracted	Rooted			72.7042	74.6723	1.9681
	4018	Divided						1.02707
	4587	Subtracted	Measured			8218.07	8354	135.93
	4609	Divided						1.01654
2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor (ec 2.4.1.45) (udp-galactose-ceramide galactosyltransferase) (ceramide udp-galactosyltransferase) (cerebroside synthase). [swissprot;acc:q16880]	1636		Squared	UGT8		42455.4	40720.1	1.04262
	2121	Subtracted						1735.3
	2443	Divided	Measured			7480.51	7708.55	1.03048
	2870	Subtracted						228.04
	3647	Divided	Rooted			69.2456	71.2917	1.02955
	3828	Subtracted						2.0461
	4270		Ranked			207	205.097	1.903
	4455	Divided						1.00928
2-hydroxyphytanoyl-coa lyase (ec 4.1.-.-) (2-hpcl) (hspc279). [swissprot;acc:q9uj83]	870	Subtracted		HACL1		207.026	201.99	5.036
	930	Divided	Rooted			69.8925	72.6721	1.03977
	941		Ranked			207.026	201.99	1.02493
	1089	Subtracted	Rooted			69.8925	72.6721	2.7796
	1128		Squared		High confidence	29261.2	32473.8	3212.6

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.