MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2425 to 2474 of 66312 in total

Filtered  : 1

description	Rank	Hugo	Value Type	Network Comparison Type	Interaction Map	red	green	network_comparison
60s ribosomal protein l28. [swissprot;acc:p46779]	2495	RPL28	Rooted	Divided	Low confidence	71.5207	73.9251	1.03362
	2503		Measured	Subtracted		7939	8178.26	239.26
	2551			Divided				1.03014
	2599		Rooted	Subtracted		71.5207	73.9251	2.4044
	2650		Squared			45172.8	43564.1	1608.7
	2654		Ranked			203.065	199.576	3.489
	2733			Divided				1.01748
	2760		Squared			45172.8	43564.1	1.03693
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	159	RPL29	Ranked	Subtracted		216.79	205.07	11.72
	169			Divided				1.05715
	177		Rooted			66.7116	70.9396	1.06338
	207			Subtracted				4.228
	538		Squared	Divided		44886.1	42318.5	1.06067
	597			Subtracted				2567.6
	921		Measured	Divided		7363.79	7652.55	1.03921
	964		Squared	Subtracted	High confidence	24025.9	27585.7	3559.8
	1013			Divided				1.14817
	1188		Measured	Subtracted	Low confidence	7363.79	7652.55	288.76
	1613				High confidence	6079.19	6503.12	423.93
	1648			Divided				1.06973
	2030		Rooted	Subtracted		65.822	67.511	1.689
	2090			Divided				1.02566
	2664		Ranked			204.768	204.549	1.00107
	2668			Subtracted				0.219
60s ribosomal protein l3-like. [swissprot;acc:q92901]	229	RPL3L				242.195	266.663	24.468
	312			Divided				1.10103
	392		Rooted			50.3313	45.6913	1.10155
	664			Subtracted				4.64
	1975		Squared	Divided	Low confidence	42327.1	40681	1.04046
	1999				High confidence	12491.1	13633.8	1.09148
	2114		Measured			3617.81	3430.31	1.05466
	2404			Subtracted				187.5
	2486		Squared		Low confidence	42327.1	40681	1646.1
	2492				High confidence	12491.1	13633.8	1142.7
	4545		Measured	Divided	Low confidence	7506.11	7639.55	1.01778
	4599			Subtracted				133.44
	4624		Ranked			207.074	208.441	1.367
	4635			Divided				1.0066
	4775		Rooted			69.3271	70.4623	1.01637
	4781			Subtracted				1.1352
60s ribosomal protein l30. [swissprot;acc:p04645]	286	RPL30	Ranked		High confidence	242.593	265.365	22.772
	378			Divided				1.09387
	502		Rooted			50.4616	46.2257	1.09164
	762			Subtracted				4.2359
	1889		Squared	Divided		12981.1	14211.2	1.09476
	2279		Rooted		Low confidence	69.5081	71.8891	1.03426
	2386		Measured		High confidence	3674.02	3529.35	1.04099
	2393				Low confidence	7609.67	7843.65	1.03075
	2440		Squared	Subtracted	High confidence	12981.1	14211.2	1230.1
	2507		Measured			3674.02	3529.35	144.67

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.