MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	description	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2408 to 2457 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
aquaporin 5. [swissprot;acc:p55064]	Subtracted	2690	Ranked	AQP5	188.192	0.144	188.048
aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	Divided	192	Squared	AQP2	71387.4	1.34524	96033.4
		526	Measured		10639.9	1.13886	12117.4
		1074	Rooted		82.3408	1.05005	86.4617
		2691	Ranked		188.193	1.00077	188.048
	Subtracted	126	Squared		71387.4	24646	96033.4
		198	Measured		10639.9	1477.5	12117.4
		784	Rooted		82.3408	4.1209	86.4617
		2689	Ranked		188.193	0.145	188.048
aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	Divided	194	Squared	AQP1	71346.6	1.34505	95965.1
		528	Measured		10635.3	1.13879	12111.4
		1080	Rooted		82.3212	1.05001	86.4383
		2694	Ranked		188.223	1.00075	188.081
	Subtracted	128	Squared		71346.6	24618.5	95965.1
		200	Measured		10635.3	1476.1	12111.4
		787	Rooted		82.3212	4.1171	86.4383
		2694	Ranked		188.223	0.142	188.081
arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	Divided	1184		GIT1	216.729	1.02586	222.334
		1795	Squared		26807.7	1.09907	29463.6
		2219	Measured		5853.67	1.0484	6136.97
		2675	Rooted		62.4892	1.00424	62.7542
	Subtracted	1142	Ranked		216.729	5.605	222.334
		1491	Squared		26807.7	2655.9	29463.6
		2189	Measured		5853.67	283.3	6136.97
		2675	Rooted		62.4892	0.265	62.7542
arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	Divided	1110	Ranked	GIT2	216.78	1.02769	222.782
		1810	Squared		26702.8	1.09823	29325.9
		2252	Measured		5840.54	1.04665	6113.01
		2705	Rooted		62.4411	1.0024	62.5908
	Subtracted	1070	Ranked		216.78	6.002	222.782
		1522	Squared		26702.8	2623.1	29325.9
		2210	Measured		5840.54	272.47	6113.01
		2697	Rooted		62.4411	0.1497	62.5908
arg/abl-interacting protein 2 isoform 2; arg binding protein 2. [refseq;acc:nm_021069]	Divided	436	Measured	SORBS2	6230.94	1.15042	7168.2
		438	Squared		28863.2	1.21371	35031.5
		653	Rooted		64.4927	1.07825	69.539
		947	Ranked		212.51	1.03567	205.191
	Subtracted	373	Squared		28863.2	6168.3	35031.5
		402	Measured		6230.94	937.26	7168.2
		547	Rooted		64.4927	5.0463	69.539
		944	Ranked		212.51	7.319	205.191
arginase 1 (ec 3.5.3.1) (liver-type arginase). [swissprot;acc:p05089]	Divided	906	Squared	ARG1	25498.1	1.15843	29537.7
		1852	Measured		6271.17	1.06375	6670.97
		1885	Ranked		204.44	1.01064	206.615
		2362	Rooted		66.5228	1.01754	67.6894
	Subtracted	779	Squared		25498.1	4039.6	29537.7
		1706	Measured		6271.17	399.8	6670.97
		1907	Ranked		204.44	2.175	206.615
		2340	Rooted		66.5228	1.1666	67.6894
arginase ii, mitochondrial precursor (ec 3.5.3.1) (non-hepatic arginase) (kidney-type arginase). [swissprot;acc:p78540]	Divided	904	Squared	ARG2	25492.1	1.15861	29535.4

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.