MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1201	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	no value	Subtracted	219.354	224.699	5.345
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	SDHA	Divided	210.986	216.344	1.0254
1202	diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384]	DPH2		227.274	233.041	1.02537
	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	no value	Subtracted	219.354	224.699	5.345
1203	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	TNFAIP1	Divided	219.023	213.606	1.02536
1204	keratin associated protein 1.5. [refseq;acc:nm_031957]	no value	Subtracted	219.354	224.699	5.345
	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]	KCTD13	Divided	219.022	213.607	1.02535
1205	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	KRTAP5-8	Subtracted	219.354	224.699	5.345
	ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590]	KIF21A	Divided	224.805	219.251	1.02533
1206	integral membrane protein cii-3b. [sptrembl;acc:o75609]	no value		207.646	212.891	1.02526
	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]		Subtracted	219.354	224.699	5.345
1207	keratin associated protein 4.4. [refseq;acc:nm_032524]	KRTAP4-4
	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	SDHC	Divided	207.644	212.888	1.02525
1208	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	no value	Subtracted	219.354	224.699	5.345
	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]		Divided	224.878	219.342	1.02524
1209	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	SDHB		207.931	213.175	1.02522
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	TRMU	Subtracted	146.036	140.692	5.344
1210	keratin associated protein 9.2. [refseq;acc:nm_031961]	KRTAP9-8		219.353	224.678	5.325
	kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139]	KIF2A	Divided	224.764	219.241	1.02519
1211	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	C11orf2		214.364	219.759	1.02517
	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	COPB2	Subtracted	174.387	179.697	5.31
1212	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	COPG
	kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]	KIF13A	Divided	214.364	219.759	1.02517
1213	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	COPZ1	Subtracted	174.387	179.697	5.31
	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	COG2	Divided	214.364	219.759	1.02517
1214	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	ARCN1	Subtracted	174.387	179.697	5.31
	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	no value	Divided	214.364	219.759	1.02517
1215	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1		218.268	212.916	1.02514
	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	PPIE	Subtracted	174.387	179.697	5.31
1216	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]	COPZ2
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	ZMIZ1	Divided	218.269	212.918	1.02513
1217	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]	QRSL1		211.959	217.258	1.025
	hyaluronan synthase 2 (ec 2.4.1.212) (hyaluronate synthase 2) (hyaluronic acid synthase 2) (ha synthase 2). [swissprot;acc:q92819]	HAS2	Subtracted	221.093	226.399	5.306
1218	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	FAAH	Divided	211.959	217.258	1.025
	hyaluronan synthase 1 (ec 2.4.1.212) (hyaluronate synthase 1) (hyaluronic acid synthase 1) (ha synthase 1) (huhas1). [swissprot;acc:q92839]	HAS1	Subtracted	221.093	226.399	5.306
1219	coactosin-like protein. [swissprot;acc:q14019]	COTL1	Divided	211.959	217.258	1.025
	hyaluronan synthase 3 (ec 2.4.1.212) (hyaluronate synthase 3) (hyaluronic acid synthase 3) (ha synthase 3). [swissprot;acc:o00219]	HAS3	Subtracted	221.093	226.399	5.306
1220	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]	QRSL1		211.959	217.258	5.299
	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	UNG	Divided			1.025
1221	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]	FAAH	Subtracted			5.299
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	PET112L	Divided			1.025
1222	coactosin-like protein. [swissprot;acc:q14019]	COTL1	Subtracted			5.299
	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	TPD52L1	Divided	206.774	211.936	1.02496
1223	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	TPD52		206.771	211.926	1.02493
	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	UNG	Subtracted	211.959	217.258	5.299
1224	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	FPGS	Divided	225.906	231.524	1.02487
	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]	PET112L	Subtracted	211.959	217.258	5.299
1225	interleukin-4 induced protein 1 precursor (fig-1 protein). [swissprot;acc:q96rq9]	IL4I1		219.55	214.288	5.262
	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	UBE2E1	Divided	166.846	170.989	1.02483

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.