MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1201	RAD52	dna repair protein rad52 homolog. [swissprot;acc:p43351]	Low confidence	203.852	199.266	1.02301
	SDHA	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	High confidence	210.986	216.344	1.0254
1202	DPH2	diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384]		227.274	233.041	1.02537
	PIGT	phosphatidylinositol glycan class t precursor. [refseq;acc:nm_015937]	Low confidence	204.636	200.036	1.023
1203	PI15	protease inhibitor 15 preproprotein; 25 kda trypsin inhibitor. [refseq;acc:nm_015886]		203.323	198.756	1.02298
	TNFAIP1	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	High confidence	219.023	213.606	1.02536
1204	KCTD13	polymerase delta-interacting protein 1; tnfaip1-like. [refseq;acc:nm_178863]		219.022	213.607	1.02535
	R3HDML	r3h domain (binds single-stranded nucleic acids) containing-like. [refseq;acc:nm_178491]	Low confidence	203.323	198.756	1.02298
1205	KIF21A	ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590]	High confidence	224.805	219.251	1.02533
	NXF1	nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	Low confidence	197.84	193.402	1.02295
1206	no value	integral membrane protein cii-3b. [sptrembl;acc:o75609]	High confidence	207.646	212.891	1.02526
	CD109	cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	Low confidence	203.629	208.303	1.02295
1207	NXF5	nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]		197.868	193.428
	SDHC	succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor (integral membrane protein cii-3) (qps1) (qps-1) (succinate dehydrogenase complex subunit c) (succinate-ubiquinone oxidoreductase cytochrome b large subunit) (cybl). [swissprot;acc:q99643]	High confidence	207.644	212.888	1.02525
1208	no value	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]		224.878	219.342	1.02524
	NXF3	nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]	Low confidence	197.863	193.425	1.02294
1209	no value	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]		202.873	198.325	1.02293
	SDHB	succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial precursor (ec 1.3.5.1) (ip) (iron-sulfur subunit of complex ii). [swissprot;acc:p21912]	High confidence	207.931	213.175	1.02522
1210	KIF2A	kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139]		224.764	219.241	1.02519
	SNAPC3	snrna activating protein complex 50 kda subunit (snapc 50 kda subunit) (proximal sequence element-binding transcription factor beta subunit) (pse-binding factor beta subunit) (ptf beta subunit). [swissprot;acc:q92966]	Low confidence	202.718	198.176	1.02292
1211	ARPC5	arp2/3 complex 16 kda subunit (p16-arc) (actin-related protein 2/3 complex subunit 5). [swissprot;acc:o15511]		201.559	197.042
	C11orf2	chromosome 11 open reading frame2; chromosome 11 open reading frame2. [refseq;acc:nm_013265]	High confidence	214.364	219.759	1.02517
1212	KIF13A	kinesin-like protein kif13a (kinesin-like protein rbkin). [swissprot;acc:q9h1h9]
	MFAP1	microfibrillar-associated protein 1. [swissprot;acc:p55081]	Low confidence	202.718	198.176	1.02292
1213	COG2	conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	High confidence	214.364	219.759	1.02517
	PRODH2	kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	Low confidence	198.145	193.707	1.02291
1214	no value	kinesin-like protein kif13b (kinesin-like protein gakin). [swissprot;acc:q9nqt8]	High confidence	214.364	219.759	1.02517
	EVI1	ecotropic virus integration 1 site protein. [swissprot;acc:q03112]	Low confidence	203.266	198.72	1.02288
1215	CETN3	centrin 3. [swissprot;acc:o15182]		197.302	192.899	1.02283
	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	High confidence	218.268	212.916	1.02514
1216	TFAP2A	transcription factor ap-2 alpha (ap2-alpha) (activating enhancer- binding protein 2 alpha) (ap-2 transcription factor) (activator protein-2) (ap-2). [swissprot;acc:p05549]	Low confidence	203.197	198.662	1.02283
	ZMIZ1	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	High confidence	218.269	212.918	1.02513
1217	DHPS	deoxyhypusine synthase (ec 2.5.1.46) (dhs). [swissprot;acc:p49366]	Low confidence	201.691	197.19	1.02283
	QRSL1	glutaminyl-trna synthase (glutamine-hydrolyzing)-like 1. [refseq;acc:nm_018292]	High confidence	211.959	217.258	1.025
1218	FAAH	fatty-acid amide hydrolase (ec 3.1.-.-) (oleamide hydrolase) (anandamide amidohydrolase). [swissprot;acc:o00519]
	TFAP2C	transcription factor ap-2 gamma (ap2-gamma) (activating enhancer- binding protein 2 gamma) (transcription factor erf-1). [swissprot;acc:q92754]	Low confidence	203.197	198.662	1.02283
1219	COTL1	coactosin-like protein. [swissprot;acc:q14019]	High confidence	211.959	217.258	1.025
	TFAP2B	transcription factor ap-2 beta (ap2-beta) (activating enhancer-binding protein 2 beta). [swissprot;acc:q92481]	Low confidence	203.197	198.662	1.02283
1220	no value	histone h4. [swissprot;acc:p02304]		202.096	197.587	1.02282
	UNG	uracil-dna glycosylase, mitochondrial precursor (ec 3.2.2.-) (udg). [swissprot;acc:p13051]	High confidence	211.959	217.258	1.025
1221	PET112L	probable glutamyl-trna(gln) amidotransferase subunit b, mitochondrial precursor (ec 6.3.5.-) (glu-adt subunit b) (cytochrome oxidase assembly factor pet112 homolog). [swissprot;acc:o75879]
	TPTE	putative protein-tyrosine phosphatase tpte (ec 3.1.3.48). [swissprot;acc:p56180]	Low confidence	203.336	198.8	1.02282
1222	ATP1A3	sodium/potassium-transporting atpase alpha-3 chain (ec 3.6.3.9) (sodium pump 3) (na+/k+ atpase 3) (alpha(iii)). [swissprot;acc:p13637]		203.529	198.989
	TPD52L1	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	High confidence	206.774	211.936	1.02496
1223	PLEKHF2	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	Low confidence	204.15	199.597	1.02281
	TPD52	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	High confidence	206.771	211.926	1.02493
1224	FPGS	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]		225.906	231.524	1.02487
	TPTE2	tpte and pten homologous inositol lipid phosphatase. [refseq;acc:nm_130785]	Low confidence	203.335	198.8	1.02281
1225	DHCR7	7-dehydrocholesterol reductase (ec 1.3.1.21) (7-dhc reductase) (sterol delta-7-reductase) (putative sterol reductase sr-2). [swissprot;acc:q9ubm7]		203.51	198.973	1.0228
	UBE2E1	ubiquitin-conjugating enzyme e2 e1 (ec 6.3.2.19) (ubiquitin-protein ligase e1) (ubiquitin carrier protein e1) (ubch6). [swissprot;acc:p51965]	High confidence	166.846	170.989	1.02483

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.