MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 25 to 74 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
7	HLX	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	Divided	High confidence	215	1.49767	322
	OSBPL3	oxysterol binding protein-related protein 3 (osbp-related protein 3) (orp-3). [swissprot;acc:q9h4l5]		Low confidence	318	1.325	240
	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Subtracted			78
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		High confidence	288.754	76.2	212.554
8	HBS1L	hbs1-like. [refseq;acc:nm_006620]	Divided		215	1.49767	322
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Subtracted	Low confidence	305.472	58.226	247.246
	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]		High confidence	288	74	362
	OSBPL7	oxysterol binding protein-related protein 7 (osbp-related protein 7) (orp-7). [swissprot;acc:q9bzf2]	Divided	Low confidence	318	1.325	240
9	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Subtracted	High confidence	288	74	362
	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	Low confidence	58	1.31818	44
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted		305.399	58.186	247.213
	XAB1	xpa binding protein 1; mbd2 interactor protein; putative atp(gtp)-binding protein. [refseq;acc:nm_007266]	Divided	High confidence	212	1.45755	309
10	ATPBD1C	protein x 0004. [refseq;acc:nm_016301]
	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Subtracted	Low confidence	305.303	58.134	247.169
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Divided		58	1.31818	44
	SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Subtracted	High confidence	288	74	362
11	BEST1	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	Divided	Low confidence	37.318	1.30966	28.4944
	PRSS3	trypsin iii precursor (ec 3.4.21.4) (brain trypsinogen) (mesotrypsinogen) (trypsin iv). [swissprot;acc:p35030]	Subtracted		304.548	57.724	246.824
	RINT1	rad50-interacting protein 1. [refseq;acc:nm_021930]	Divided	High confidence	337	1.45259	232
	TMEM33	db83 protein. [swissprot;acc:p57088]	Subtracted		288	74	362
12	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]			266.856	69.377	336.233
	BEST4	vitelliform macular dystrophy 2-like protein 2. [refseq;acc:nm_153274]	Divided	Low confidence	37.3475	1.30933	28.5242
	PRSS1	trypsin i precursor (ec 3.4.21.4) (cationic trypsinogen). [swissprot;acc:p07477]	Subtracted		304.359	57.622	246.737
	RHOBTB2	rho-related btb domain-containing protein 2 (deleted in breast cancer 2 gene protein) (p83). [swissprot;acc:q9byz6]	Divided	High confidence	337	1.45259	232
13	no value	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]		Low confidence	37.9984	1.30207	29.1831
	GNG12	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]	Subtracted	High confidence	266.856	69.377	336.233
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Divided		288.754	1.3585	212.554
			Subtracted	Low confidence	255.046	52.684	202.362
14	ATG4A	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	Divided	High confidence	56.6768	1.32952	75.3531
	BEST2	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]		Low confidence	37.9984	1.30207	29.1831
	CYP27B1	25-hydroxyvitamin d-1 alpha hydroxylase, mitochondrial precursor (ec 1.14.-.-) (25-ohd-1 alpha-hydroxylase) (25-hydroxyvitamin d3 1- alpha-hydroxylase) (vd3 1a hydroxylase) (p450c1 alpha) (p450vd1- alpha). [swissprot;acc:o15528]	Subtracted		286.396	47.92	238.476
	GNG4	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		High confidence	266.863	69.328	336.191
15	CYP27A1	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]		Low confidence	286.347	47.893	238.454
	GNG3	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]		High confidence	266.863	69.327	336.19
	MAP1LC3B	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	Divided		56.7244	1.32914	75.3948
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]		Low confidence	255.046	1.26035	202.362
16	CYP24A1	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]	Subtracted		284.798	47.055	237.743
	GNG8	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		High confidence	266.864	69.32	336.184
	JMJD1C	thyroid receptor interacting protein 8 (trip-8) (fragment). [swissprot;acc:q15652]	Divided	Low confidence	305.472	1.2355	247.246
	MAP1LC3A	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]		High confidence	56.7252	1.32913	75.3954
17	ATG4B	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]			56.7841	1.32866	75.447
	BOK	bcl2-related ovarian killer. [refseq;acc:nm_032515]	Subtracted	Low confidence	265.638	42.403	223.235
	GNG5	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 subunit. [swissprot;acc:p30670]		High confidence	266.864	69.318	336.182
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Divided	Low confidence	305.399	1.23537	247.213
18	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]		High confidence	185.678	1.32082	245.247
	GNG10	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Subtracted		266.865	69.316	336.181
	JMJD1A	jumonji domain containing 1; zinc finger protein; testis-specific protein a. [refseq;acc:nm_018433]	Divided	Low confidence	305.303	1.2352	247.169
	PRKRAP1	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Subtracted		273.188	40.698	232.49
19	no value	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		High confidence	266.865	69.313	336.178
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		Low confidence	188.298	40.211	228.509

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.