MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 2375 to 2424 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	network_comparison	green
594	CRK	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Subtracted	High confidence	207.26	12.914	194.346
	NAV3	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	Divided	Low confidence	204.073	1.03031	198.07
595	ABL2	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Subtracted	High confidence	207.26	12.914	194.346
	ABTB1	ankyrin repeat and btb (poz) domain containing 1 isoform 1; elongation factor 1a binding protein. [refseq;acc:nm_032548]	Divided	Low confidence	205.485	1.03024	199.453
	BUD31	g10 protein homolog (edg-2). [swissprot;acc:p41223]	Subtracted		201.67	5.941	195.729
	VAV1	vav proto-oncogene. [swissprot;acc:p15498]	Divided	High confidence	212.2	1.0618	199.849
596	no value	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Subtracted		207.26	12.914	194.346
	CDK2AP2	doc-1 related protein (doc-1r). [swissprot;acc:o75956]		Low confidence	216.618	5.928	210.69
	RBX1	ring-box 1; ring box protein 1; regulator of cullins 1; ring finger protein; zyp protein. [refseq;acc:nm_014248]	Divided		205.485	1.03024	199.453
	VAV3	vav-3 protein. [swissprot;acc:q9ukw4]		High confidence	212.253	1.06175	199.908
597	ARID1B	brg1-binding protein eld/osa1; eld (eyelid)/osa protein. [refseq;acc:nm_020732]		Low confidence	204.856	1.03018	198.854
	DDX17	probable rna-dependent helicase p72 (dead-box protein p72) (dead-box protein 17). [swissprot;acc:q92841]	Subtracted		204.837	5.924	198.913
	HCK	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]		High confidence	207.26	12.914	194.346
	VAV2	vav-2 protein. [swissprot;acc:p52735]	Divided		212.526	1.0615	200.212
598	AKT1	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]			248.463	1.06138	234.095
	ARID1A	swi/snf-related, matrix-associated, actin-dependent regulator of chromatin subfamily f member 1 (swi-snf complex protein p270) (b120). [swissprot;acc:o14497]		Low confidence	204.843	1.03013	198.851
	DDX5	probable rna-dependent helicase p68 (dead-box protein p68) (dead-box protein 5). [swissprot;acc:p17844]	Subtracted		204.832	5.916	198.916
	GRAP2	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]		High confidence	207.261	12.914	194.347
599	AKT3	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Divided		248.463	1.06138	234.095
	CRKL	crk-like protein. [swissprot;acc:p46109]	Subtracted		207.26	12.914	194.346
	JARID2	jumonji protein. [swissprot;acc:q92833]		Low confidence	207.726	5.913	201.813
	SFRS3	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	Divided		208.383	1.03012	202.291
600	ABL1	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Subtracted	High confidence	207.26	12.914	194.346
	AKT2	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	Divided		248.463	1.06138	234.095
	ING3	inhibitor of growth family, member 3. [refseq;acc:nm_019071]		Low confidence	210.546	1.02997	204.42
	NEUROG2	neurogenin 2 (fragment). [swissprot;acc:q9h2a3]	Subtracted		216.554	5.912	210.642
601	CROT	peroxisomal carnitine octanoyltransferase (ec 2.3.1.-) (cot). [swissprot;acc:q9ukg9]	Divided		208.67	1.02995	202.603
	FYN	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Subtracted	High confidence	207.26	12.914	194.346
	NEUROD2	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		Low confidence	216.554	5.912	210.642
	VPS39	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	Divided	High confidence	206.274	1.06069	218.792
602	FGR	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]	Subtracted		207.26	12.914	194.346
	MAP4	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	Divided		206.274	1.06069	218.792
	NEUROD6	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Subtracted	Low confidence	216.552	5.911	210.641
	SH2D3C	sh2 domain containing 3c; novel sh2-containing protein 3; sh2 domain-containing 3c; likely ortholog of mouse cas/hef1-associated signal transducer. [refseq;acc:nm_005489]	Divided		201.426	1.0299	195.579
603	BCAR3	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]			201.427	1.02986	195.587
	CUTL1	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Subtracted	High confidence	207.27	12.902	194.368
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Divided		225.829	1.0605	212.945
	NEUROD1	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	Subtracted	Low confidence	216.552	5.911	210.641
604	CUTL2	homeobox protein cux-2 (cut-like 2) (fragment). [swissprot;acc:o14529]		High confidence	207.272	12.901	194.371
	NEUROD4	neurogenic differentiation factor 4 (neurod4). [swissprot;acc:q9hd90]		Low confidence	216.552	5.911	210.641
	RPL15	60s ribosomal protein l15. [swissprot;acc:p39030]	Divided	High confidence	217.862	1.0602	230.978
	RPL36	60s ribosomal protein l36. [swissprot;acc:q9y3u8]		Low confidence	205.116	1.02983	211.234
605	CDK2AP1	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	Subtracted		216.501	5.899	210.602
	DDX17	probable rna-dependent helicase p72 (dead-box protein p72) (dead-box protein 17). [swissprot;acc:q92841]	Divided		204.837	1.02978	198.913
	HIST1H2BL	histone h2b.c (h2b/c). [swissprot;acc:q99880]		High confidence	247.47	1.0601	233.441
	LEF1	lymphoid enhancer binding factor 1 (lef-1) (t cell-specific transcription factor 1-alpha) (tcf1-alpha). [swissprot;acc:q9uju2]	Subtracted		225.829	12.884	212.945
606	no value	dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (ec 2.4.1.-) (dol-p-man dependent alpha(1-3)-mannosyltransferase) (not56-like protein). [swissprot;acc:q92685]	Divided	Low confidence	200.085	1.02977	194.301
	G3BP1	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Subtracted		211.28	5.886	217.166
	HIST2H2BA	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	Divided	High confidence	247.47	1.0601	233.441
	WASL	neural wiskott-aldrich syndrome protein (n-wasp). [swissprot;acc:o00401]	Subtracted		207.309	12.857	194.452

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.