MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 2358 to 2407 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	network_comparison	green
1179	keratin associated protein 9-4; keratin associated protein 9.4. [refseq;acc:nm_033191]	no value	Subtracted	219.356	5.367	224.723
1180	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	SDHA		210.986	5.358	216.344
	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]	ATP6V0B	Divided	218.186	1.02593	212.672
1181	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]	DAZAP1	Subtracted	218.268	5.352	212.916
	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	SGCG	Divided	218.186	1.02593	212.672
1182	neurocalcin delta. [swissprot;acc:p29554]	NCALD		225.104	1.02589	230.931
	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	ZMIZ1	Subtracted	218.269	5.351	212.918
1183	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]	no value		219.354	5.346	224.7
	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	HPCA	Divided	225.103	1.02588	230.928
1184	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	GIT1		216.729	1.02586	222.334
	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	no value	Subtracted	219.354	5.346	224.7
1185	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]
	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	HPCAL1	Divided	225.094	1.02585	230.913
1186	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]	no value		218.402	1.02582	212.904
	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	STARD6	Subtracted	219.354	5.346	224.7
1187	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	STARD5
	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	ATP6V0D1	Divided	218.402	1.02582	212.904
1188	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	ARL4A
	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]	no value	Subtracted	219.354	5.346	224.7
1189	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		Divided	209.649	1.02565	204.406
	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	LIMS1	Subtracted	219.354	5.346	224.7
1190	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]	ILK
	ubiquitin. [swissprot;acc:p02248]	UBB	Divided	209.6	1.02558	204.372
1191	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	STARD4	Subtracted	219.354	5.346	224.7
	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	UBP1	Divided	220.742	1.02558	215.237
1192	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	RSU1	Subtracted	219.354	5.346	224.7
	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	TFCP2	Divided	220.742	1.02558	215.237
1193	lbp-9. [refseq;acc:nm_014553]	TFCP2L1
	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	G3BP1	Subtracted	219.354	5.346	224.7
1194	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	G3BP2
	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	SFRS3	Divided	220.742	1.02558	215.237
1195	espin. [refseq;acc:nm_031475]	ESPNP	Subtracted	219.354	5.346	224.7
	skeletal muscle lim-protein 3 (slim 3) (lim-domain protein dral) (four and a half lim domains protein 2) (fhl-2). [swissprot;acc:q14192]	FHL2	Divided	269.608	1.02554	276.493
1196	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	CYP2D6	Subtracted	219.354	5.346	224.7
	kinesin protein. [refseq;acc:nm_032559]	KIF2B	Divided	224.858	1.02551	219.264
1197	mstp028 protein. [refseq;acc:nm_031954]	KCTD10		219.042	1.02548	213.6
	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	PLEKHC1	Subtracted	219.354	5.346	224.7
1198	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	LIMS2
	skeletal muscle lim-protein 2 (slim 2) (four and a half lim domains protein 3) (fhl-3). [swissprot;acc:q13643]	FHL3	Divided	269.59	1.02546	276.454
1199	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	DRD4	Subtracted	219.354	5.346	224.7
	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	MPHOSPH10	Divided	241.496	1.02543	235.508
1200	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	no value	Subtracted	219.354	5.345	224.699
	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	SMARCB1	Divided	219.03	1.0254	213.604
1201	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	no value	Subtracted	219.354	5.345	224.699
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	SDHA	Divided	210.986	1.0254	216.344
1202	diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384]	DPH2		227.274	1.02537	233.041
	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	no value	Subtracted	219.354	5.345	224.699
1203	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]
	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	TNFAIP1	Divided	219.023	1.02536	213.606
1204	keratin associated protein 1.5. [refseq;acc:nm_031957]	no value	Subtracted	219.354	5.345	224.699

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.