MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2358 to 2407 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1179	MARCH8	cellular modulator of immune recognition. [refseq;acc:nm_145021]	Divided	218.186	212.672	1.02593
1180	ATP6V0B	vacuolar atp synthase 21 kda proteolipid subunit (ec 3.6.3.14) (hatpl). [swissprot;acc:q99437]
	SDHA	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	Subtracted	210.986	216.344	5.358
1181	DAZAP1	daz associated protein 1 isoform b; deleted in azoospermia associated protein 1. [refseq;acc:nm_018959]		218.268	212.916	5.352
	SGCG	gamma-sarcoglycan (gamma-sg) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q13326]	Divided	218.186	212.672	1.02593
1182	NCALD	neurocalcin delta. [swissprot;acc:p29554]		225.104	230.931	1.02589
	ZMIZ1	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Subtracted	218.269	212.918	5.351
1183	no value	keratin associated protein 4-14; keratin associated protein 4.14. [refseq;acc:nm_033059]		219.354	224.7	5.346
	HPCA	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	Divided	225.103	230.928	1.02588
1184	no value	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Subtracted	219.354	224.7	5.346
	GIT1	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	Divided	216.729	222.334	1.02586
1185	no value	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Subtracted	219.354	224.7	5.346
	HPCAL1	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]	Divided	225.094	230.913	1.02585
1186	no value	adp-ribosylation factor-like protein 7 (adp-ribosylation factor-like protein lak). [swissprot;acc:p56559]		218.402	212.904	1.02582
	STARD6	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Subtracted	219.354	224.7	5.346
1187	ATP6V0D1	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase ac39 subunit) (v-atpase 40 kda accessory protein) (p39) (32 kda accessory protein). [swissprot;acc:p12953]	Divided	218.402	212.904	1.02582
	STARD5	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Subtracted	219.354	224.7	5.346
1188	no value	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]
	ARL4A	adp-ribosylation factor-like protein 4. [swissprot;acc:p40617]	Divided	218.402	212.904	1.02582
1189	no value	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		209.649	204.406	1.02565
	LIMS1	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	Subtracted	219.354	224.7	5.346
1190	ILK	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
	UBB	ubiquitin. [swissprot;acc:p02248]	Divided	209.6	204.372	1.02558
1191	STARD4	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	Subtracted	219.354	224.7	5.346
	UBP1	upstream binding protein 1 (lbp-1a). [refseq;acc:nm_014517]	Divided	220.742	215.237	1.02558
1192	RSU1	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	Subtracted	219.354	224.7	5.346
	TFCP2	transcription factor cp2; transcription factor cp2, alpha globin. [refseq;acc:nm_005653]	Divided	220.742	215.237	1.02558
1193	G3BP1	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Subtracted	219.354	224.7	5.346
	TFCP2L1	lbp-9. [refseq;acc:nm_014553]	Divided	220.742	215.237	1.02558
1194	G3BP2	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	Subtracted	219.354	224.7	5.346
	SFRS3	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]	Divided	220.742	215.237	1.02558
1195	ESPNP	espin. [refseq;acc:nm_031475]	Subtracted	219.354	224.7	5.346
	FHL2	skeletal muscle lim-protein 3 (slim 3) (lim-domain protein dral) (four and a half lim domains protein 2) (fhl-2). [swissprot;acc:q14192]	Divided	269.608	276.493	1.02554
1196	CYP2D6	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	Subtracted	219.354	224.7	5.346
	KIF2B	kinesin protein. [refseq;acc:nm_032559]	Divided	224.858	219.264	1.02551
1197	KCTD10	mstp028 protein. [refseq;acc:nm_031954]		219.042	213.6	1.02548
	PLEKHC1	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	Subtracted	219.354	224.7	5.346
1198	FHL3	skeletal muscle lim-protein 2 (slim 2) (four and a half lim domains protein 3) (fhl-3). [swissprot;acc:q13643]	Divided	269.59	276.454	1.02546
	LIMS2	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	Subtracted	219.354	224.7	5.346
1199	DRD4	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]
	MPHOSPH10	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	Divided	241.496	235.508	1.02543
1200	no value	keratin associated protein 4-10; keratin associated protein 4.10. [refseq;acc:nm_033060]	Subtracted	219.354	224.699	5.345
	SMARCB1	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily b member 1 (integrase interactor 1 protein) (hsnf5) (baf47). [swissprot;acc:q12824]	Divided	219.03	213.604	1.0254
1201	no value	keratin associated protein 4-2; keratin associated protein 4.2. [refseq;acc:nm_033062]	Subtracted	219.354	224.699	5.345
	SDHA	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	Divided	210.986	216.344	1.0254
1202	no value	keratin associated protein 4.3 (fragment). [sptrembl;acc:q9byr4]	Subtracted	219.354	224.699	5.345
	DPH2	diphthamide biosynthesis-like protein 2. [refseq;acc:nm_001384]	Divided	227.274	233.041	1.02537
1203	no value	keratin associated protein 2-4; keratin associated protein 2.4. [refseq;acc:nm_033184]	Subtracted	219.354	224.699	5.345
	TNFAIP1	tumor necrosis factor, alpha-induced protein 1, endothelial (b12 protein). [swissprot;acc:q13829]	Divided	219.023	213.606	1.02536
1204	no value	keratin associated protein 1.5. [refseq;acc:nm_031957]	Subtracted	219.354	224.699	5.345

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.