MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2358 to 2407 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
590	Ranked	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	217.215	204.279	1.06333
	Squared	oligoribonuclease, mitochondrial precursor (ec 3.1.-.-) (small fragment nuclease) (cgi-114). [swissprot;acc:q9y3b8]	23526.4	27879.3	1.18502
	Rooted	transforming protein p21a (k-ras 2a) (ki-ras) (c-k-ras). [swissprot;acc:p01116]	108.671	100.365	1.08276
591	Measured	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	6740.5	7644.76	1.13415
	Ranked	ribonuclease p protein subunit p30 (ec 3.1.26.5) (rnasep protein p30) (rnase p subunit 2). [swissprot;acc:p78346]	216.72	230.439	1.0633
	Squared	choline o-acetyltransferase (ec 2.3.1.6) (choactase) (choline acetylase) (chat). [swissprot;acc:p28329]	23526.5	27879.4	1.18502
	Rooted	leucine-rich repeat protein shoc-2 (ras-binding protein sur-8). [swissprot;acc:q9uq13]	108.659	100.356	1.08274
592	Measured	histone h2b.c (h2b/c). [swissprot;acc:q99880]	3946.32	4475.47	1.13409
	Ranked	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	91.63	97.4011	1.06298
	Squared	voltage-gated potassium channel beta-2 subunit (k+ channel beta-2 subunit) (kv-beta-2) (hkvbeta2). [swissprot;acc:q13303]	23526.4	27879.3	1.18502
	Rooted	ral guanine nucleotide dissociation stimulator-like 2 (ralgds-like factor) (ras-associated protein rab2l). [swissprot;acc:o15211]	108.659	100.356	1.08274
593	Measured	histone h2b.q (h2b/q) (h2b-gl105). [swissprot;acc:q16778]	3946.32	4475.47	1.13409
	Ranked	tata-binding protein-associated phosphoprotein (down-regulator of transcription 1) (dr1 protein). [swissprot;acc:q01658]	232.118	218.406	1.06278
	Squared	aflatoxin b1 aldehyde reductase 1 (ec 1.-.-.-) (afb1-ar 1) (aldoketoreductase 7). [swissprot;acc:o43488]	23526.4	27879.3	1.18502
	Rooted	transforming protein p21/h-ras-1 (c-h-ras). [swissprot;acc:p01112]	108.653	100.352	1.08272
594	Measured	histone h3.1 (h3/a) (h3/c) (h3/d) (h3/f) (h3/h) (h3/i) (h3/j) (h3/k) (h3/l). [swissprot;acc:p16106]	3946.32	4475.47	1.13409
	Ranked	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	223.282	210.136	1.06256
	Squared	importin alpha-1 subunit (karyopherin alpha-1 subunit) (srp1-beta) (rag cohort protein 2) (nucleoprotein interactor 1) (npi-1). [swissprot;acc:p52294]	23517.1	27867.3	1.18498
	Rooted	transforming protein n-ras. [swissprot;acc:p01111]	108.65	100.35	1.08271
595	Measured	histone h2b. [refseq;acc:nm_175055]	3946.32	4475.47	1.13409
	Ranked	vav proto-oncogene. [swissprot;acc:p15498]	212.2	199.849	1.0618
	Squared	5'-amp-activated protein kinase, catalytic alpha-2 chain (ec 2.7.1.-) (ampk alpha-2 chain). [swissprot;acc:p54646]	34129.7	40434.8	1.18474
	Rooted	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	51.2427	55.468	1.08246
596	Measured	histone h2b.s (h2b/s). [swissprot;acc:p57053]	3946.32	4475.47	1.13409
	Ranked	vav-3 protein. [swissprot;acc:q9ukw4]	212.253	199.908	1.06175
	Squared	5'-amp-activated protein kinase, gamma-1 subunit (ampk gamma-1 chain) (ampkg). [swissprot;acc:p54619]	34129.6	40434.5	1.18473
	Rooted	cbf1 interacting corepressor. [refseq;acc:nm_004882]	60.0587	65.0057	1.08237
597	Measured	histone h2b.d (h2b/d). [swissprot;acc:q99877]	3946.32	4475.47	1.13409
	Ranked	vav-2 protein. [swissprot;acc:p52735]	212.526	200.212	1.0615
	Squared	5'-amp-activated protein kinase, catalytic alpha-1 chain (ec 2.7.1.-) (ampk alpha-1 chain). [swissprot;acc:q13131]	34129.4	40434.2	1.18473
	Rooted	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	60.0587	65.0057	1.08237
598	Measured	histone h3.4 (h3t) (h3/t) (h3/g). [swissprot;acc:q16695]	3946.32	4475.47	1.13409
	Ranked	rac-alpha serine/threonine kinase (ec 2.7.1.-) (rac-pk-alpha) (protein kinase b) (pkb) (c-akt). [swissprot;acc:p31749]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, beta-2 subunit (ampk beta-2 chain). [swissprot;acc:o43741]	34129.6	40434.5	1.18473
	Rooted	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	61.2527	66.2644	1.08182
599	Measured	testis-specific histone h2b; h2b histone family, member u, (testis-specific). [refseq;acc:nm_170610]	3946.32	4475.47	1.13409
	Ranked	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, gamma-3 subunit (ampk gamma-3 chain) (ampk gamma3). [swissprot;acc:q9ugi9]	34129.6	40434.5	1.18473
	Rooted	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	138.375	127.926	1.08168
600	Measured	histone h2b.e (h2b/e). [swissprot;acc:q99879]	3946.32	4475.47	1.13409
	Ranked	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	248.463	234.095	1.06138
	Squared	5'-amp-activated protein kinase, beta-1 subunit (ampk beta-1 chain) (ampkb). [swissprot;acc:q9y478]	34129.6	40434.5	1.18473
	Rooted	trs85 homolog. [swissprot;acc:q9y2l5]	138.375	127.926	1.08168
601	Measured	symplekin. [swissprot;acc:q92797]	15213.4	13418.1	1.1338
	Ranked	vam6/vps39-like protein (hvam6p). [swissprot;acc:q96jc1]	206.274	218.792	1.06069
	Squared	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	34129.6	40434.5	1.18473
	Rooted	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	138.032	127.651	1.08132
602	Measured	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	4864.66	5514.87	1.13366
	Ranked	microtubule-associated protein 4 (map 4). [swissprot;acc:p27816]	206.274	218.792	1.06069
	Squared	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]	19129.8	22652.9	1.18417

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.