MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2308 to 2357 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

Rank	description	Hugo	Interaction Map	red	green	network_comparison
1154	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	PPA1	High confidence	224.307	230.242	1.02646
1155	homeobox protein otx1. [swissprot;acc:p32242]	OTX1	Low confidence	205.629	200.937	1.02335
	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	PPA2	High confidence	224.307	230.242	1.02646
1156	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	AIPL1
	cone-rod homeobox protein. [swissprot;acc:o43186]	CRX	Low confidence	205.625	200.934	1.02335
1157	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	AIP	High confidence	224.307	230.242	1.02646
	tfiih basal transcription factor complex helicase subunit (ec 3.6.1.-) (dna-repair protein complementing xp-d cells) (xeroderma pigmentosum group d complementing protein) (cxpd) (dna excision repair protein ercc-2). [swissprot;acc:p18074]	ERCC2	Low confidence	201.354	196.761	1.02334
1158	diaphanous protein homolog 1 (diaphanous-related formin 1) (drf1). [swissprot;acc:o60610]	DIAPH1		200.185	195.622	1.02333
	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	EPS8L2	High confidence	221.877	216.167	1.02641
1159	4-hydroxyphenylpyruvate dioxygenase (ec 1.13.11.27) (4hppd) (hpd) (hppdase). [swissprot;acc:p32754]	HPD	Low confidence	203.422	198.786	1.02332
	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	PROSC	High confidence	170.28	165.898	1.02641
1160	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]	OGDH		208.55	214.041	1.02633
	mitochondrial carnitine/acylcarnitine carrier protein (carnitine/acylcarnitine translocase) (cac). [swissprot;acc:o43772]	SLC25A20	Low confidence	201.192	196.61	1.02331
1161	kappa b-ras 1. [refseq;acc:nm_020345]	no value	High confidence	220.758	215.097	1.02632
	nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]		Low confidence	199.768	195.217	1.02331
1162	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	ATP6V0A4		192.287	187.907
	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]	NKIRAS2	High confidence	220.758	215.097	1.02632
1163	snare associated protein snapin. [refseq;acc:nm_012437]	SNAPAP
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	LSM1	Low confidence	201.482	196.897	1.02329
1164	adp-ribosylation factor 3. [swissprot;acc:p16587]	ARF3		202.869	198.252
	transducin-like enhancer protein 4. [swissprot;acc:q04727]	TLE4	High confidence	219.438	213.818	1.02628
1165	adp-ribosylation factor 4. [swissprot;acc:p18085]	ARF4	Low confidence	202.831	198.216	1.02328
	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	TLE3	High confidence	219.401	213.785	1.02627
1166	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Low confidence	201.081	196.508	1.02327
	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	TLE2	High confidence	219.374	213.759	1.02627
1167	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	EN2		219.399	213.784	1.02626
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	Low confidence	200.738	196.177	1.02325
1168	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	CXXC1	High confidence	219.399	213.784	1.02626
	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	NOL5A	Low confidence	201.212	196.641	1.02325
1169	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	ABT1	High confidence	219.399	213.784	1.02626
	xpmc2 prevents mitotic catastrophe 2 homolog; xenopus prevents mitotic catastrophe 2 homolog. [refseq;acc:nm_020385]	REXO4	Low confidence	200.521	195.967	1.02324
1170	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	no value	High confidence	219.399	213.784	1.02626
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	ATP6V0A1	Low confidence	192.255	187.889	1.02324
1171	cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]	CFL1		201.061	196.497	1.02323
	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	HECW1	High confidence	219.399	213.784	1.02626
1172	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]	no value		219.375	213.767	1.02623
	zinc transporter 3 (znt-3). [swissprot;acc:q99726]	SLC30A3	Low confidence	204.466	199.824	1.02323
1173	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	DPH1	High confidence	229.243	235.246	1.02619
	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	SRP9	Low confidence	201.084	196.52	1.02322
1174	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	COPE	High confidence	187.964	192.849	1.02599
	diaphanous protein homolog 3 (diaphanous-related formin 3) (drf3) (fragment). [swissprot;acc:q9nsv4]	DIAPH3	Low confidence	200.258	195.713	1.02322
1175	cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]	CFL2		201.033	196.473	1.02321
	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	ATP6V0C	High confidence	218.186	212.672	1.02593
1176	destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282]	DSTN	Low confidence	201.013	196.457	1.02319
	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	SGCZ	High confidence	218.186	212.672	1.02593
1177	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]	ACBD3
	sodium/calcium exchanger 1 precursor (na(+)/ca(2+)-exchange protein 1). [swissprot;acc:p32418]	SLC8A1	Low confidence	203.938	199.317	1.02318
1178	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	SGCD	High confidence	218.186	212.672	1.02593
	sodium/calcium exchanger 2 precursor (na(+)/ca(2+)-exchange protein 2). [swissprot;acc:q9upr5]	SLC8A2	Low confidence	203.938	199.317	1.02318
1179	cellular modulator of immune recognition. [refseq;acc:nm_145021]	MARCH8	High confidence	218.186	212.672	1.02593

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.