MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Filtered	Interaction Map	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2308 to 2357 of 12912 in total

Network Comparison Type  : Divided
Filtered  : 1
Interaction Map  : High confidence

Rank	Value Type	description	red	green	network_comparison
577	Rooted	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	121.695	131.815	1.08316
578	Measured	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	6739.81	7644.62	1.13425
	Ranked	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	224.606	210.944	1.06477
	Squared	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	23534.9	27890.2	1.18506
	Rooted	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	121.695	131.815	1.08316
579	Measured	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	6739.82	7644.62	1.13425
	Ranked	zinc finger protein t86. [swissprot;acc:o00488]	246.805	231.796	1.06475
	Squared	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	23526.4	27879.4	1.18503
	Rooted	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	121.695	131.815	1.08316
580	Measured	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	6739.83	7644.63	1.13425
	Ranked	zinc ribbon domain containing, 1; transcription-associated zinc ribbon protein; rna polymerase i small specific subunit rpa12. [refseq;acc:nm_014596]	236.751	252.038	1.06457
	Squared	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	23526.4	27879.3	1.18502
	Rooted	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	121.695	131.815	1.08316
581	Measured	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	6739.82	7644.63	1.13425
	Ranked	t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	237.28	252.492	1.06411
	Squared	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]	23526.4	27879.3	1.18502
	Rooted	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	121.695	131.815	1.08316
582	Measured	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	6739.82	7644.62	1.13425
	Ranked	homeobox protein barh-like 1. [swissprot;acc:q9hbu1]	237.28	252.492	1.06411
	Squared	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]	23526.4	27879.3	1.18502
	Rooted	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	121.695	131.815	1.08316
583	Measured	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	6739.81	7644.62	1.13425
	Ranked	opsin 4 (melanopsin). [swissprot;acc:q9uhm6]	237.28	252.492	1.06411
	Squared	aflatoxin b1 aldehyde reductase 2 (ec 1.-.-.-) (afb1-ar 2). [swissprot;acc:o95154]	23526.4	27879.3	1.18502
	Rooted	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	121.695	131.815	1.08316
584	Measured	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	6739.82	7644.63	1.13425
	Ranked	t-cell leukemia homeobox protein 2 (homeobox protein hox-11l1) (neural crest homeobox protein). [swissprot;acc:o43763]	237.28	252.492	1.06411
	Squared	alpha/beta hydrolase domain containing protein 3; lung alpha/beta hydrolase 3. [refseq;acc:nm_138340]	23526.4	27879.3	1.18502
	Rooted	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	104.459	113.143	1.08313
585	Measured	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	6739.82	7644.63	1.13425
	Ranked	t-cell leukemia homeobox protein 1 (homeobox protein hox-11) (tcl-3 proto-oncogene). [swissprot;acc:p31314]	237.28	252.492	1.06411
	Squared	golgi membrane protein sb140; smooth muscle cell associated protein 5. [refseq;acc:nm_030799]	23526.4	27879.3	1.18502
	Rooted	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	51.5667	55.8498	1.08306
586	Measured	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	6739.81	7644.62	1.13425
	Ranked	hect domain containing protein 1 (fragment). [swissprot;acc:q9ult8]	237.28	252.492	1.06411
	Squared	alpha/beta hydrolase domain containing protein 1 isoform 2; lung alpha/beta hydrolase protein 1. [refseq;acc:nm_152870]	23526.4	27879.3	1.18502
	Rooted	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	51.5667	55.8498	1.08306
587	Measured	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	6739.83	7644.63	1.13425
	Ranked	homeobox protein barh-like 2. [swissprot;acc:q9umq3]	237.28	252.492	1.06411
	Squared	methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (ec 1.2.1.27) (mmsdh). [swissprot;acc:q02252]	23526.5	27879.4	1.18502
	Rooted	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	51.7204	56.0156	1.08305
588	Measured	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	6739.83	7644.63	1.13425
	Ranked	shwachman-bodian-diamond syndrome protein (cgi-97). [swissprot;acc:q9y3a5]	216.557	230.362	1.06375
	Squared	10 kda heat shock protein, mitochondrial (hsp10) (10 kda chaperonin) (cpn10). [swissprot;acc:q04984]	23526.4	27879.3	1.18502
	Rooted	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	59.7294	64.6872	1.083
589	Measured	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	6739.85	7644.63	1.13424
	Ranked	u6 snrna-associated sm-like protein lsm2 (small nuclear ribonuclear protein d homolog) (g7b) (snrnp core sm-like protein sm-x5). [swissprot;acc:q9y333]	228.215	214.546	1.06371
	Squared	rab acceptor 1 (prenylated); prenylated rab acceptor 1. [refseq;acc:nm_006423]	23526.4	27879.3	1.18502
	Rooted	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	59.7294	64.6872	1.083
590	Measured	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	6739.85	7644.63	1.13424

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.