MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2308 to 2357 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1154	PPA1	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	High confidence	224.307	230.242	1.02646
1155	OTX1	homeobox protein otx1. [swissprot;acc:p32242]	Low confidence	205.629	200.937	1.02335
	PPA2	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	High confidence	224.307	230.242	1.02646
1156	AIPL1	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]
	CRX	cone-rod homeobox protein. [swissprot;acc:o43186]	Low confidence	205.625	200.934	1.02335
1157	AIP	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	High confidence	224.307	230.242	1.02646
	ERCC2	tfiih basal transcription factor complex helicase subunit (ec 3.6.1.-) (dna-repair protein complementing xp-d cells) (xeroderma pigmentosum group d complementing protein) (cxpd) (dna excision repair protein ercc-2). [swissprot;acc:p18074]	Low confidence	201.354	196.761	1.02334
1158	DIAPH1	diaphanous protein homolog 1 (diaphanous-related formin 1) (drf1). [swissprot;acc:o60610]		200.185	195.622	1.02333
	EPS8L2	epidermal growth factor receptor pathway substrate 8-like protein 2; eps8-related protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2. [refseq;acc:nm_022772]	High confidence	221.877	216.167	1.02641
1159	HPD	4-hydroxyphenylpyruvate dioxygenase (ec 1.13.11.27) (4hppd) (hpd) (hppdase). [swissprot;acc:p32754]	Low confidence	203.422	198.786	1.02332
	PROSC	proline synthetase co-transcribed bacterial homolog protein. [swissprot;acc:o94903]	High confidence	170.28	165.898	1.02641
1160	OGDH	2-oxoglutarate dehydrogenase e1 component, mitochondrial precursor (ec 1.2.4.2) (alpha-ketoglutarate dehydrogenase). [swissprot;acc:q02218]		208.55	214.041	1.02633
	SLC25A20	mitochondrial carnitine/acylcarnitine carrier protein (carnitine/acylcarnitine translocase) (cac). [swissprot;acc:o43772]	Low confidence	201.192	196.61	1.02331
1161	no value	kappa b-ras 1. [refseq;acc:nm_020345]	High confidence	220.758	215.097	1.02632
		nucleoside diphosphate kinase b (ec 2.7.4.6) (ndk b) (ndp kinase b) (nm23-h2) (c-myc purine-binding transcription factor puf). [swissprot;acc:p22392]	Low confidence	199.768	195.217	1.02331
1162	ATP6V0A4	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]		192.287	187.907
	NKIRAS2	i-kappa-b-interacting ras-like protein 2. [refseq;acc:nm_017595]	High confidence	220.758	215.097	1.02632
1163	LSM1	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Low confidence	201.482	196.897	1.02329
	SNAPAP	snare associated protein snapin. [refseq;acc:nm_012437]	High confidence	220.758	215.097	1.02632
1164	ARF3	adp-ribosylation factor 3. [swissprot;acc:p16587]	Low confidence	202.869	198.252	1.02329
	TLE4	transducin-like enhancer protein 4. [swissprot;acc:q04727]	High confidence	219.438	213.818	1.02628
1165	ARF4	adp-ribosylation factor 4. [swissprot;acc:p18085]	Low confidence	202.831	198.216	1.02328
	TLE3	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	High confidence	219.401	213.785	1.02627
1166	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Low confidence	201.081	196.508	1.02327
	TLE2	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	High confidence	219.374	213.759	1.02627
1167	EN2	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]		219.399	213.784	1.02626
	RGL1	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Low confidence	200.738	196.177	1.02325
1168	CXXC1	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	High confidence	219.399	213.784	1.02626
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Low confidence	201.212	196.641	1.02325
1169	ABT1	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	High confidence	219.399	213.784	1.02626
	REXO4	xpmc2 prevents mitotic catastrophe 2 homolog; xenopus prevents mitotic catastrophe 2 homolog. [refseq;acc:nm_020385]	Low confidence	200.521	195.967	1.02324
1170	no value	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	High confidence	219.399	213.784	1.02626
	ATP6V0A1	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	Low confidence	192.255	187.889	1.02324
1171	CFL1	cofilin, non-muscle isoform (18 kda phosphoprotein) (p18). [swissprot;acc:p23528]		201.061	196.497	1.02323
	HECW1	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	High confidence	219.399	213.784	1.02626
1172	no value	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]		219.375	213.767	1.02623
	SLC30A3	zinc transporter 3 (znt-3). [swissprot;acc:q99726]	Low confidence	204.466	199.824	1.02323
1173	DPH1	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	High confidence	229.243	235.246	1.02619
	SRP9	signal recognition particle 9 kda protein (srp9). [swissprot;acc:p49458]	Low confidence	201.084	196.52	1.02322
1174	COPE	coatomer epsilon subunit (epsilon-coat protein) (epsilon-cop). [swissprot;acc:o14579]	High confidence	187.964	192.849	1.02599
	DIAPH3	diaphanous protein homolog 3 (diaphanous-related formin 3) (drf3) (fragment). [swissprot;acc:q9nsv4]	Low confidence	200.258	195.713	1.02322
1175	ATP6V0C	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	High confidence	218.186	212.672	1.02593
	CFL2	cofilin, muscle isoform (cofilin 2). [swissprot;acc:q9y281]	Low confidence	201.033	196.473	1.02321
1176	DSTN	destrin (actin-depolymerizing factor) (adf). [swissprot;acc:p18282]		201.013	196.457	1.02319
	SGCZ	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	High confidence	218.186	212.672	1.02593
1177	ACBD3	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	SLC8A1	sodium/calcium exchanger 1 precursor (na(+)/ca(2+)-exchange protein 1). [swissprot;acc:p32418]	Low confidence	203.938	199.317	1.02318
1178	SGCD	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	High confidence	218.186	212.672	1.02593
	SLC8A2	sodium/calcium exchanger 2 precursor (na(+)/ca(2+)-exchange protein 2). [swissprot;acc:q9upr5]	Low confidence	203.938	199.317	1.02318
1179	MARCH8	cellular modulator of immune recognition. [refseq;acc:nm_145021]	High confidence	218.186	212.672	1.02593

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.