MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 230 to 279 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	red	green	network_comparison
60s acidic ribosomal protein p1. [swissprot;acc:p05386]	898	Divided	no value	229.171	238.048	1.03874
60s acidic ribosomal protein p2. [swissprot;acc:p05387]	621	Subtracted	RPLP2	231.92	244.435	12.515
	720	Divided				1.05396
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	267	Subtracted	no value	243.12	266.661	23.541
	357	Divided				1.09683
60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]	264	Subtracted		243.24	266.796	23.556
	356	Divided				1.09684
60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	283	Subtracted	MRPL11	242.37	265.255	22.885
	373	Divided				1.09442
60s ribosomal protein l11. [swissprot;acc:p39026]	201	Subtracted	RPL11	241.828	267.346	25.518
	283	Divided				1.10552
60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	246	Subtracted	no value	243.583	267.528	23.945
	338	Divided				1.0983
60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	281	Subtracted	MRPL12	242.159	265.104	22.945
	369	Divided				1.09475
60s ribosomal protein l12. [swissprot;acc:p30050]	247	Subtracted	no value	243.583	267.527	23.944
	337	Divided				1.0983
60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	325	Subtracted	MRPL13	241.828	263.62	21.792
	390	Divided				1.09011
60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	327	Subtracted	RPL13A	241.83	263.615	21.785
	392	Divided				1.09008
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	222	Subtracted	no value	242.153	266.673	24.52
	306	Divided				1.10126
60s ribosomal protein l15. [swissprot;acc:p39030]	577	Subtracted	RPL15	217.862	230.978	13.116
	604	Divided				1.0602
60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	200	Subtracted	no value	241.808	267.335	25.527
	281	Divided				1.10557
60s ribosomal protein l18. [swissprot;acc:q07020]	411	Subtracted	RPL18	237.109	254.667	17.558
	485	Divided				1.07405
60s ribosomal protein l18a. [swissprot;acc:q02543]	819	Subtracted	no value	234.025	224.958	9.067
	860	Divided				1.04031
60s ribosomal protein l19. [swissprot;acc:p14118]	245	Subtracted	RPL19	240.73	264.729	23.999
	319	Divided				1.09969
60s ribosomal protein l21. [swissprot;acc:p46778]	1019	Subtracted	no value	223.958	217.263	6.695
	1054	Divided				1.03082
60s ribosomal protein l22 (epstein-barr virus small rna associated protein) (eber associated protein) (eap) (heparin binding protein hbp15). [swissprot;acc:p35268]	2205			199.129	200.413	1.00645
	2229	Subtracted				1.284
60s ribosomal protein l23 (l17). [swissprot;acc:p23131]	208			240.782	265.717	24.935
	293	Divided				1.10356
60s ribosomal protein l23a. [swissprot;acc:p29316]	243	Subtracted		241.884	265.945	24.061
	323	Divided				1.09947
60s ribosomal protein l24 (l30). [swissprot;acc:p38663]	1767		RPL24	201.288	198.86	1.01221
	1821	Subtracted				2.428
60s ribosomal protein l26. [swissprot;acc:q02877]	217		RPL26	242.326	267.008	24.682
	302	Divided				1.10185
60s ribosomal protein l28. [swissprot;acc:p46779]	1868	Subtracted	RPL28	215.896	213.61	2.286
	1882	Divided				1.0107
60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	2664		RPL29	204.768	204.549	1.00107
	2668	Subtracted				0.219
60s ribosomal protein l3-like. [swissprot;acc:q92901]	229		RPL3L	242.195	266.663	24.468

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.