MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 230 to 279 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	1292	NONO	Low confidence	200.544	196.152	1.02239
	2532		High confidence	190.405	190.812	1.00214
5t4 oncofetal trophoblast glycoprotein; 5t4-antigen. [refseq;acc:nm_006670]	3485	TPBG	Low confidence	202.475	199.484	1.01499
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6pf-2-k/fru- 2,6-p2ase liver isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:p16118]	3865	PFKFB1		194.792	197.306	1.01291
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6pf-2-k/fru- 2,6-p2ase heart-type isozyme) (pfk-2/fbpase-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:o60825]	3867	PFKFB2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6pf-2-k/fru- 2,6-p2ase brain/placenta-type isozyme) (ipfk-2) [includes: 6- phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16875]	3864	PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (6pf-2-k/fru- 2,6-p2ase testis-type isozyme) [includes: 6-phosphofructo-2-kinase (ec 2.7.1.105); fructose-2,6-bisphosphatase (ec 3.1.3.46)]. [swissprot;acc:q16877]	3868	PFKFB4
6-phosphofructokinase, liver type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme b) (pfk-b). [swissprot;acc:p17858]	1822	PFKL	High confidence	240.32	243.085	1.01151
	2739		Low confidence	200.929	197.479	1.01747
6-phosphofructokinase, muscle type (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme a) (pfk-a) (phosphofructokinase-m). [swissprot;acc:p08237]	1830	PFKM	High confidence	240.32	243.069	1.01144
	2769		Low confidence	200.94	197.499	1.01742
6-phosphofructokinase, type c (ec 2.7.1.11) (phosphofructokinase 1) (phosphohexokinase) (phosphofructo-1-kinase isozyme c) (pfk-c) (6-phosphofructokinase, platelet type). [swissprot;acc:q01813]	1883	PFKP	High confidence	240.317	242.881	1.01067
	2706		Low confidence	200.868	197.403	1.01755
6-phosphogluconate dehydrogenase, decarboxylating (ec 1.1.1.44). [swissprot;acc:p52209]	1923	PGD		201.484	197.59	1.01971
	2274		High confidence	213.642	214.801	1.00542
6-phosphogluconolactonase (ec 3.1.1.31) (6pgl). [swissprot;acc:o95336]	1584	PGLS		216.891	220.432	1.01633
	2807		Low confidence	200.157	196.756	1.01729
6-pyruvoyl tetrahydrobiopterin synthase (ec 4.2.3.12) (ptps) (ptp synthase). [swissprot;acc:q03393]	2904	PTS	High confidence	0.00001	0.00001	1
	4128		Low confidence	198.355	196.271	1.01062
60 kda heat shock protein, mitochondrial precursor (hsp60) (60 kda chaperonin) (cpn60) (heat shock protein 60) (hsp-60) (mitochondrial matrix protein p1) (p60 lymphocyte protein) (hucha60). [swissprot;acc:p10809]	2588	HSPD1	High confidence	222.305	222.64	1.00151
	2591		Low confidence	199.427	195.908	1.01796
60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	826	HTATIP	High confidence	223.186	213.912	1.04335
	3722		Low confidence	200.338	197.651	1.01359
60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	1092	RPLP0	High confidence	226.203	232.855	1.02941
	3897		Low confidence	202.202	199.673	1.01267
60s acidic ribosomal protein p1. [swissprot;acc:p05386]	898	no value	High confidence	229.171	238.048	1.03874
	4994		Low confidence	203.12	203.189	1.00034
60s acidic ribosomal protein p2. [swissprot;acc:p05387]	720	RPLP2	High confidence	231.92	244.435	1.05396
	1982		Low confidence	204.808	200.886	1.01952
60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	357	no value	High confidence	243.12	266.661	1.09683
	4740		Low confidence	207.452	208.569	1.00538
60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]	356		High confidence	243.24	266.796	1.09684
	4858		Low confidence	207.503	208.103	1.00289
60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	373	MRPL11	High confidence	242.37	265.255	1.09442
	4601		Low confidence	208.668	210.165	1.00717
60s ribosomal protein l11. [swissprot;acc:p39026]	283	RPL11	High confidence	241.828	267.346	1.10552
	2678		Low confidence	208.542	212.217	1.01762
60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	338	no value	High confidence	243.583	267.528	1.0983
	4667		Low confidence	206.86	208.125	1.00612
60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	369	MRPL12	High confidence	242.159	265.104	1.09475
	3886		Low confidence	204.522	201.949	1.01274
60s ribosomal protein l12. [swissprot;acc:p30050]	337	no value	High confidence	243.583	267.527	1.0983
	4669		Low confidence	206.837	208.096	1.00609
60s ribosomal protein l13 (breast basic conserved protein 1). [swissprot;acc:p26373]	3643	RPL13		203.892	201.053	1.01412
60s ribosomal protein l13, mitochondrial (l13mt). [swissprot;acc:q9byd1]	390	MRPL13	High confidence	241.828	263.62	1.09011
	4867		Low confidence	206.138	205.562	1.0028
60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]	392	RPL13A	High confidence	241.83	263.615	1.09008
	4738		Low confidence	206.344	207.457	1.00539
60s ribosomal protein l14 (cag-isl 7). [swissprot;acc:p50914]	306	no value	High confidence	242.153	266.673	1.10126
	4097		Low confidence	202.12	199.957	1.01082

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.