MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2280 to 2329 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	green	network_comparison
570	SMARCD2	swi/snf-related matrix-associated actin-dependent regulator of chromatin d2; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60b; swp73-like protein; chromatin remodeling complex baf60b subunit; swi/snf complex 60 kda subunit b. [refseq;acc:nm_003077]	Measured	4134.77	4691.24	1.13458
571	FTL	ferritin light chain (ferritin l subunit). [swissprot;acc:p02792]	Rooted	62.7424	67.9648	1.08324
	GALK2	n-acetylgalactosamine kinase (ec 2.7.1.-) (galnac kinase) (galactokinase 2). [swissprot;acc:q01415]	Squared	17799.8	21105.3	1.1857
	MDH2	malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	Ranked	238.529	254.099	1.06528
	SMARCD3	swi/snf-related matrix-associated actin-dependent regulator of chromatin d3; rsc6p; mammalian chromatin remodeling complex brg1-associated factor 60c; swp73-like protein; chromatin remodeling complex baf60c subunit; swi/snf complex 60 kda subunit c. [refseq;acc:nm_003078]	Measured	4134.77	4691.24	1.13458
572	no value	cbf1 interacting corepressor. [refseq;acc:nm_004882]	Ranked	227.86	213.945	1.06504
		galactose-1-phosphate uridylyltransferase (ec 2.7.7.12) (gal-1-p uridylyltransferase) (udp-glucose--hexose-1-phosphate uridylyltransferase). [swissprot;acc:p07902]	Squared	17799.8	21105.3	1.1857
	DLGAP4	disks large-associated protein 4 (dap-4) (sap90/psd-95-associated protein 4) (sapap4) (psd-95/sap90 binding protein 4). [swissprot;acc:q9y2h0]	Rooted	62.7424	67.9648	1.08324
	SMARCD1	swi/snf related, matrix associated, actin dependent regulator of chromatin subfamily d member 1 (swi/snf complex 60 kda subunit) (brg1- associated factor 60a). [swissprot;acc:q96gm5]	Measured	4134.77	4691.24	1.13458
573	FTMT	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Rooted	62.7427	67.9648	1.08323
	GALE	udp-glucose 4-epimerase (ec 5.1.3.2) (galactowaldenase) (udp- galactose 4-epimerase). [swissprot;acc:q14376]	Squared	17799.8	21105.3	1.1857
	GPATCH1	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	Ranked	227.86	213.945	1.06504
	HOXA10	homeobox protein hox-a10 (hox-1h) (hox-1.8) (pl). [swissprot;acc:p31260]	Measured	6739.43	7644.55	1.1343
574	ASNSD1	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	Squared	26570.7	31504.6	1.18569
	FTHL17	ferritin heavy polypeptide-like 17. [swissprot;acc:q9bxu8]	Rooted	62.7456	67.9646	1.08318
	HOXB9	homeobox protein hox-b9 (hox-2e) (hox-2.5). [swissprot;acc:p17482]	Measured	6739.61	7644.58	1.13428
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Ranked	221.807	208.264	1.06503
575	no value	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Rooted	121.695	131.815	1.08316
	ATP6V1A	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Squared	26570.7	31504.6	1.18569
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Ranked	221.807	208.264	1.06503
	HOXA9	homeobox protein hox-a9 (hox-1g). [swissprot;acc:p31269]	Measured	6739.63	7644.59	1.13427
576	no value	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]	Ranked	235.18	250.419	1.0648
	ASNS	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]	Squared	26570.7	31504.6	1.18569
	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Rooted	121.695	131.815	1.08316
	HOXC9	homeobox protein hox-c9 (hox-3b). [swissprot;acc:p31274]	Measured	6739.7	7644.6	1.13426
577	ASAH1	acid ceramidase precursor (ec 3.5.1.23) (acylsphingosine deacylase) (n-acylsphingosine amidohydrolase) (ac) (putative 32 kda heart protein) (php32). [swissprot;acc:q13510]	Squared	36109.8	42811.6	1.1856
	GABRG3	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	Measured	6739.81	7644.62	1.13425
	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Rooted	121.695	131.815	1.08316
	PRSS7	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	Ranked	224.606	210.944	1.06477
578	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Rooted	121.695	131.815	1.08316
	FOXG1	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	Measured	6739.81	7644.62	1.13425
	KPNA6	importin alpha-6 subunit (karyopherin alpha-5 subunit). [swissprot;acc:o15131]	Squared	23534.9	27890.2	1.18506
	SF3B2	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	Ranked	224.606	210.944	1.06477
579	GABRG1	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	Measured	6739.82	7644.62	1.13425
	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Rooted	121.695	131.815	1.08316
	KCNAB3	voltage-gated potassium channel beta-3 subunit (k+ channel beta-3 subunit) (kv-beta-3). [swissprot;acc:o43448]	Squared	23526.4	27879.4	1.18503
	ZNF593	zinc finger protein t86. [swissprot;acc:o00488]	Ranked	246.805	231.796	1.06475
580	GABRA2	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	Measured	6739.83	7644.63	1.13425
	HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Rooted	121.695	131.815	1.08316
	YIF1A	yip1 interacting factor homolog; yip1p-interacting factor; putative rab5-interacting protein; putative transmembrane protein 54tmp. [refseq;acc:nm_020470]	Squared	23526.4	27879.3	1.18502
	ZNRD1	zinc ribbon domain containing, 1; transcription-associated zinc ribbon protein; rna polymerase i small specific subunit rpa12. [refseq;acc:nm_014596]	Ranked	236.751	252.038	1.06457
581	GABRA6	gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]	Measured	6739.82	7644.63	1.13425
	HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Rooted	121.695	131.815	1.08316
	KCNAB1	voltage-gated potassium channel beta-1 subunit (k+ channel beta-1 subunit) (kv-beta-1). [swissprot;acc:q14722]	Squared	23526.4	27879.3	1.18502
	TLX3	t-cell leukemia homeobox protein 3 (homeobox protein hox-11l2). [swissprot;acc:o43711]	Ranked	237.28	252.492	1.06411
582	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	Rooted	121.695	131.815	1.08316
	BARX1	homeobox protein barh-like 1. [swissprot;acc:q9hbu1]	Ranked	237.28	252.492	1.06411
	GABRG2	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Measured	6739.82	7644.62	1.13425
	YIF1B	similar to putative transmembrane protein; homolog of yeast golgi membrane protein yif1p (yip1p-interacting factor). [refseq;acc:nm_033557]	Squared	23526.4	27879.3	1.18502
583	no value	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	Measured	6739.81	7644.62	1.13425

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.