MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2258 to 2307 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
565	CYP4F12	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Divided	Low confidence	203.157	197.064	1.03092
	CYP4F8	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]	Subtracted		203.155	197.018	6.137
	ZNF547	sedlin. [swissprot;acc:o14582]	Divided	High confidence	129.219	121.261	1.06563
566	no value	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]
	CEBPZ	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	Subtracted	Low confidence	205.428	199.293	6.135
	CRNKL1	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]		High confidence	220.744	207.121	13.623
	MAK	serine/threonine-protein kinase mak (ec 2.7.1.-) (male germ cell- associated kinase). [swissprot;acc:p20794]	Divided	Low confidence	168.935	163.869	1.03091
567	ANP32C	acidic leucine-rich nuclear phosphoprotein 32 family member c (tumorigenic protein pp32r1). [swissprot;acc:o43423]			206.46	200.275	1.03088
	ING3	inhibitor of growth family, member 3. [refseq;acc:nm_019071]	Subtracted		210.546	204.42	6.126
	RPL37	60s ribosomal protein l37 (g1.16). [swissprot;acc:p02403]		High confidence	228.639	242.258	13.619
	TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	Divided		129.219	121.261	1.06563
568	no value	dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]		Low confidence	202.86	196.783	1.03088
		putative pre-mrna splicing factor rna helicase (atp-dependent rna helicase #3) (deah-box protein 16). [swissprot;acc:o60231]		High confidence	226.3	212.38	1.06554
	SFRS1	splicing factor, arginine/serine-rich 1 (pre-mrna splicing factor sf2, p33 subunit) (alternative splicing factor asf-1). [swissprot;acc:q07955]	Subtracted		228.639	242.258	13.619
	SURF6	surfeit locus protein 6. [swissprot;acc:o75683]		Low confidence	205.21	199.088	6.122
569	ANP32A	acidic leucine-rich nuclear phosphoprotein 32 family member a (potent heat-stable protein phosphatase 2a inhibitor i1pp2a) (hla-dr associated protein i) (phapi) (acidic nuclear phosphoprotein pp32) (cerebellar leucine rich acidic nuclear protein). [swissprot;acc:p39687]	Divided		206.46	200.275	1.03088
	COX15	cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	Subtracted		203.197	197.076	6.121
	GPKOW	t54 protein. [swissprot;acc:q92917]	Divided	High confidence	226.3	212.38	1.06554
	PPAT	amidophosphoribosyltransferase precursor (ec 2.4.2.14) (glutamine phosphoribosylpyrophosphate amidotransferase) (atase) (gpat). [swissprot;acc:q06203]	Subtracted		228.639	242.258	13.619
570	ANP32D	acidic leucine-rich nuclear phosphoprotein 32 family member d (tumorigenic protein pp32r2). [swissprot;acc:o95626]	Divided	Low confidence	206.46	200.275	1.03088
	RPL36	60s ribosomal protein l36. [swissprot;acc:q9y3u8]	Subtracted		205.116	211.234	6.118
	SFRS11	splicing factor arginine/serine-rich 11 (arginine-rich 54 kda nuclear protein) (p54). [swissprot;acc:q05519]	Divided	High confidence	229.709	215.631	1.06529
	SNX17	sorting nexin 17. [swissprot;acc:q15036]	Subtracted		228.639	242.258	13.619
571	no value	enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]		Low confidence	205.506	199.406	6.1
	MDH2	malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	Divided	High confidence	238.529	254.099	1.06528
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Subtracted		221.807	208.264	13.543
	USO1	general vesicular transport factor p115 (transcytosis associated protein) (tap) (vesicle docking protein). [swissprot;acc:o60763]	Divided	Low confidence	206.46	200.275	1.03088
572	no value	ba161i19.3 (similar to ribosomal protein l36). [sptrembl;acc:q8wx03]	Subtracted		205.117	211.213	6.096
		cbf1 interacting corepressor. [refseq;acc:nm_004882]	Divided	High confidence	227.86	213.945	1.06504
	ANP32B	acidic leucine-rich nuclear phosphoprotein 32 family member b (phapi2 protein) (silver-stainable protein ssp29) (acidic protein rich in leucines). [swissprot;acc:q92688]		Low confidence	206.46	200.275	1.03088
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Subtracted	High confidence	221.807	208.264	13.543
573	BRD8	bromodomain containing 8; thyroid hormone receptor coactivating protein; skeletal muscle abundant protein. [refseq;acc:nm_006696]	Divided	Low confidence	206.46	200.275	1.03088
	CYP4F12	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]	Subtracted		203.157	197.064	6.093
	GNL2	autoantigen ngp-1. [swissprot;acc:q13823]		High confidence	250.302	236.817	13.485
	GPATCH1	evolutionarily conserved g-patch domain containing. [refseq;acc:nm_018025]	Divided		227.86	213.945	1.06504
574	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]			221.807	208.264	1.06503
	NRD1	nardilysin precursor (ec 3.4.24.61) (n-arginine dibasic convertase) (nrd convertase) (nrd-c). [swissprot;acc:o43847]		Low confidence	202.855	196.78	1.03087
	POLR2D	dna-directed rna polymerase ii 16 kda polypeptide (ec 2.7.7.6) (rpb4). [swissprot;acc:o15514]	Subtracted	High confidence	237.554	250.823	13.269
	SFRS3	splicing factor, arginine/serine-rich 3 (pre-mrna splicing factor srp20) (x16 protein). [swissprot;acc:p23152]		Low confidence	208.383	202.291	6.092
575	ARPC3	arp2/3 complex 21 kda subunit (p21-arc) (actin-related protein 2/3 complex subunit 3). [swissprot;acc:o15145]	Divided		202.85	196.777	1.03086
	CDC40	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]	Subtracted	High confidence	223.282	210.136	13.146
	DDX24	atp-dependent rna helicase ddx24 (dead-box protein 24). [swissprot;acc:q9gzr7]		Low confidence	205.461	199.383	6.078
	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Divided	High confidence	221.807	208.264	1.06503
576	no value	dj408b20.3 (novel protein similar to 60s acidic ribosomal protein p2 (rplp2)). [sptrembl;acc:q9h5a9]			235.18	250.419	1.0648
		dj470l14.3 (novel protein similar to the arp2/3 protein complex subunit p21-arc (arc21)). [sptrembl;acc:q9h5b6]	Subtracted	Low confidence	202.86	196.783	6.077
	ICK	intestinal cell kinase isoform a; mak-related kinase; serine/threonine protein kinase. [refseq;acc:nm_014920]	Divided		169.097	164.039	1.03083
	POLR2G	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	Subtracted	High confidence	232.469	245.613	13.144
577	ATP6V0C	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]	Divided	Low confidence	207.131	200.94	1.03081
	NRD1	nardilysin precursor (ec 3.4.24.61) (n-arginine dibasic convertase) (nrd convertase) (nrd-c). [swissprot;acc:o43847]	Subtracted		202.855	196.78	6.075
	PRSS7	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	Divided	High confidence	224.606	210.944	1.06477

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.