MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2258 to 2307 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1129	SIX2	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	Divided	221.285	215.401	1.02732
1130	ESRRA	steroid hormone receptor err1 (estrogen-related receptor, alpha) (err-alpha) (estrogen receptor-like 1). [swissprot;acc:p11474]	Subtracted	187.022	181.391	5.631
	PA2G4	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	Divided	221.285	215.4	1.02732
1131	no value	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]		218.484	212.675	1.02731
	TLE4	transducin-like enhancer protein 4. [swissprot;acc:q04727]	Subtracted	219.438	213.818	5.62
1132	API5	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	Divided	218.484	212.675	1.02731
	FPGS	folylpolyglutamate synthase, mitochondrial precursor (ec 6.3.2.17) (folylpoly-gamma-glutamate synthetase) (fpgs). [swissprot;acc:q05932]	Subtracted	225.906	231.524	5.618
1133	no value	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]		204.404	210.022
	SEC13	sec13-related protein. [swissprot;acc:p55735]	Divided	218.484	212.675	1.02731
1134	ATP6V1G3	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]
	TLE3	transducin-like enhancer protein 3 (esg3). [swissprot;acc:q04726]	Subtracted	219.401	213.785	5.616
1135	ATP6V1B2	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]	Divided	218.484	212.675	1.02731
	EN2	homeobox protein engrailed-2 (hu-en-2). [swissprot;acc:p19622]	Subtracted	219.399	213.784	5.615
1136	CXXC1	cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]
	SEC31A	yeast sec31p homolog. [refseq;acc:nm_014933]	Divided	218.484	212.675	1.02731
1137	ABT1	activator of basal transcription 1; tata-binding protein-binding protein; basal transcriptional activator. [refseq;acc:nm_013375]	Subtracted	219.399	213.784	5.615
	ATP6V1G1	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]	Divided	218.484	212.675	1.02731
1138	no value	cytokine-like nuclear factor n-pac. [refseq;acc:nm_032569]	Subtracted	219.399	213.784	5.615
	ATP6V1E1	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]	Divided	218.484	212.675	1.02731
1139	GDAP1L1	ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]
	TLE2	transducin-like enhancer protein 2 (esg2). [swissprot;acc:q04725]	Subtracted	219.374	213.759	5.615
1140	DDX39	dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804]	Divided	218.484	212.675	1.02731
	HECW1	hect type e3 ubiquitin ligase. [refseq;acc:nm_015052]	Subtracted	219.399	213.784	5.615
1141	no value	transducin-like enhancer protein 1 (esg1). [swissprot;acc:q04724]		219.375	213.767	5.608
	GDAP1	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]	Divided	218.484	212.675	1.02731
1142	ATP6V1D	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]
	GIT1	arf gtpase-activating protein git1 (g protein-coupled receptor kinase- interactor 1). [swissprot;acc:q9y2x7]	Subtracted	216.729	222.334	5.605
1143	KIF2B	kinesin protein. [refseq;acc:nm_032559]		224.858	219.264	5.594
	SEC31B	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	Divided	218.484	212.675	1.02731
1144	ATP6V1H	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]
	SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Subtracted	135.844	130.259	5.585
1145	ATP6V1F	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]	Divided	218.481	212.675	1.0273
	KIF21A	ny-ren-62 antigen (fragment). [sptrembl;acc:q9y590]	Subtracted	224.805	219.251	5.554
1146	no value	ubiquitin. [swissprot;acc:p02248]		209.061	203.518	5.543
	ATP6V1B1	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	Divided	218.483	212.676	1.0273
1147	PEX14	peroxisomal membrane protein pex14 (peroxin-14) (peroxisomal membrane anchor protein pex14) (pts1 receptor docking protein). [swissprot;acc:o75381]		208.651	203.109	1.02729
			Subtracted			5.542
1148	no value	signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]		224.878	219.342	5.536
		ubiquitin. [swissprot;acc:p02248]	Divided	209.061	203.518	1.02724
1149	BYSL	bystin. [swissprot;acc:q13895]		239.505	233.185	1.0271
	KIF2A	kinesin-like protein kif2 (kinesin-2) (hk2). [swissprot;acc:o00139]	Subtracted	224.764	219.241	5.523
1150	ATP6V0C	vacuolar atp synthase 16 kda proteolipid subunit (ec 3.6.3.14). [swissprot;acc:p27449]		218.186	212.672	5.514
	SNX1	sorting nexin 1. [swissprot;acc:q13596]	Divided	209.868	215.522	1.02694
1151	MTX1	metaxin 1. [swissprot;acc:q13505]		199.552	204.925	1.02693
	SGCZ	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Subtracted	218.186	212.672	5.514
1152	ACBD3	golgi complex associated protein 1; golgi resident protein gcp60; peripherial benzodiazepine receptor associated protein; golgi phosphoprotein 1; pbr associated protein; pka (rialpha)-associated protein. [refseq;acc:nm_022735]
	EPS8L1	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	Divided	221.939	216.143	1.02682
1153	EPS8	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]		221.93	216.146	1.02676
	SGCD	delta-sarcoglycan (sg-delta) (35 kda dystrophin-associated glycoprotein) (35dag). [swissprot;acc:q92629]	Subtracted	218.186	212.672	5.514
1154	MARCH8	cellular modulator of immune recognition. [refseq;acc:nm_145021]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.