MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2201 to 2250 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1101	EPHB6	ephrin type-b receptor 6 precursor (tyrosine-protein kinase-defective receptor eph-6) (hep). [swissprot;acc:o15197]	Low confidence	210.722	205.826	1.02379
	KARS	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]	High confidence	220.291	226.584	1.02857
1102	no value	40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]		229.442	235.974	1.02847
	EPHA8	ephrin type-a receptor 8 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eek) (eph-and elk-related kinase) (hek3). [swissprot;acc:p29322]	Low confidence	210.722	205.826	1.02379
1103	EPHA3	ephrin type-a receptor 3 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor etk1) (hek) (hek4). [swissprot;acc:p29320]
	RPS27L	ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [refseq;acc:nm_015920]	High confidence	229.441	235.972	1.02846
1104	FZD8	frizzled 8 precursor (frizzled-8) (fz-8) (hfz8). [swissprot;acc:q9h461]	Low confidence	206.584	201.786	1.02378
	HAO1	hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	High confidence	231.922	238.486	1.0283
1105	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		191.139	185.882	1.02828
	TRIB2	tribbles homolog 2. [refseq;acc:nm_021643]	Low confidence	203.515	198.787	1.02378
1106	no value	mitochondrial carrier protein mgc4399. [refseq;acc:nm_032315]		201.02	196.352	1.02377
	PEX5L	pxr2b protein. [refseq;acc:nm_016559]	High confidence	212.945	207.109	1.02818
1107	RHCG	rh type c glycoprotein. [refseq;acc:nm_016321]	Low confidence	201.221	196.55	1.02376
	SPTLC2	serine palmitoyltransferase 2 (ec 2.3.1.50) (long chain base biosynthesis protein 2) (lcb 2) (serine-palmitoyl-coa transferase 2) (spt 2). [swissprot;acc:o15270]	High confidence	204.603	210.324	1.02796
1108	FOXK2	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]		218.006	212.119	1.02775
	VAPB	vesicle-associated membrane protein-associated protein b/c (vamp- associated protein b/c) (vamp-b/vamp-c) (vap-b/vap-c). [swissprot;acc:o95292]	Low confidence	204.27	199.529	1.02376
1109	MAPK13	mitogen-activated protein kinase 13 (ec 2.7.1.37) (stress-activated protein kinase-4) (mitogen-activated protein kinase p38 delta) (map kinase p38 delta). [swissprot;acc:o15264]		200.443	195.793	1.02375
	TPT1	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	High confidence	218.098	212.209	1.02775
1110	GIT2	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]		216.78	222.782	1.02769
	LBR	lamin b receptor (integral nuclear envelope inner membrane protein) (lmn2r). [swissprot;acc:q14739]	Low confidence	201.984	197.299	1.02375
1111	no value	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	High confidence	217.99	212.123	1.02766
	TM7SF2	delta(14)-sterol reductase (ec 1.3.1.70) (c-14 sterol reductase) (sterol c14-reductase) (delta14-sr) (transmembrane 7 superfamily member 2) (another new gene 1) (putative sterol reductase sr-1). [swissprot;acc:o76062]	Low confidence	202.004	197.323	1.02372
1112	HNF4G	hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	High confidence	251.863	258.829	1.02766
	VAPA	vesicle-associated membrane protein-associated protein a (vamp- associated protein a) (vamp-a) (vap-a) (33 kda vamp-associated protein) (vap-33). [swissprot;acc:q9p0l0]	Low confidence	204.256	199.524	1.02372
1113	CYB5R2	cytochrome b5 reductase b5r.2. [refseq;acc:nm_016229]		200.326	195.686	1.02371
	GADD45G	growth arrest and dna-damage-inducible protein gadd45 gamma (cytokine responsive protein cr6). [swissprot;acc:o95257]	High confidence	251.863	258.829	1.02766
1114	GADD45A	growth arrest and dna-damage-inducible protein gadd45 alpha (dna- damage inducible transcript 1) (ddit1). [swissprot;acc:p24522]
	SLC7A3	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3. [refseq;acc:nm_032803]	Low confidence	200.679	196.033	1.0237
1115	HNF4A	hepatocyte nuclear factor 4-alpha (hnf-4-alpha) (transcription factor hnf-4) (transcription factor 14). [swissprot;acc:p41235]	High confidence	251.863	258.829	1.02766
	SLC7A2	low-affinity cationic amino acid transporter-2 (cat-2) (cat2). [swissprot;acc:p52569]	Low confidence	200.679	196.033	1.0237
1116	DUS1L	pp3111 protein. [refseq;acc:nm_022156]		203.007	198.316	1.02365
	GADD45B	growth arrest and dna-damage-inducible protein gadd45 beta (negative growth-regulatory protein myd118) (myeloid differentiation primary response protein myd118). [swissprot;acc:o75293]	High confidence	251.863	258.829	1.02766
1117	NUCB1	nucleobindin 1 precursor (calnuc). [swissprot;acc:q02818]	Low confidence	211.871	216.875	1.02362
	NXF5	nuclear rna export factor 5 (tap-like protein 1) (tapl-1). [swissprot;acc:q9h1b4]	High confidence	168.989	164.46	1.02754
1118	NXF3	nuclear rna export factor 3 (tap-like protein 3) (tapl-3). [swissprot;acc:q9h4d5]		168.995	164.467	1.02753
	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]	Low confidence	187.49	183.168	1.0236
1119	ATP6V0A2	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	High confidence	218.528	212.676	1.02752
	BCAR1	crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	Low confidence	201.761	197.111	1.02359
1120	ASNSD1	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]		201.621	196.976	1.02358
	ATP6V0A4	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	High confidence	218.528	212.676	1.02752
1121	ATP6V0A1	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]		218.529
	RHBG	rhesus blood group, b glycoprotein; rh type b glycoprotein. [refseq;acc:nm_020407]	Low confidence	201.247	196.611	1.02358
1122	ATP6V1E1	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]		201.537	196.894
	TCIRG1	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	High confidence	218.527	212.676	1.02751
1123	ATP6V1A	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Low confidence	201.621	196.976	1.02358
	NXF1	nuclear rna export factor 1 (tip associating protein) (tip-associated protein) (mrna export factor tap). [swissprot;acc:q9ubu9]	High confidence	169.031	164.507	1.0275
1124	NPEPPS	puromycin-sensitive aminopeptidase (ec 3.4.11.-) (psa). [swissprot;acc:p55786]	Low confidence	201.395	196.76	1.02356
	PRDX5	peroxiredoxin 5, mitochondrial precursor (prx-v) (peroxisomal antioxidant enzyme) (plp) (thioredoxin peroxidase pmp20) (antioxidant enzyme b166) (aoeb166) (tpx type vi) (liver tissue 2d-page spot 71b) (alu co-repressor 1) (sbbi10). [swissprot;acc:p30044]	High confidence	207.553	213.256	1.02748
1125	no value	dj718p11.1.2 (novel class ii aminotransferase similar to serine palmotyltransferase (isoform 2)) (fragment). [sptrembl;acc:q9ugb5]		204.404	210.022
	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	Low confidence	202.352	197.698	1.02354

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.