MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Rank	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2175 to 2224 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	167	AMPD2	Subtracted	Ranked	133	105	28
	180			Squared	9924.76	25146.6	15221.8
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	87	APBA1	Divided	Rooted	42.2825	54.9687	1.30003
	97			Measured	2820.51	3897.1	1.3817
			Subtracted	Ranked	271.752	225.68	46.072
	139		Divided				1.20415
	150		Subtracted	Rooted	42.2825	54.9687	12.6862
	311			Measured	2820.51	3897.1	1076.59
	2112		Divided	Squared	11682.9	12711	1.088
	2539		Subtracted				1028.1
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	617	APPBP1			27407.7	31927.7	4520
	785		Divided				1.16492
	1576		Subtracted	Measured	6858.84	7287.27	428.43
	1909		Divided				1.06246
	2252		Subtracted	Rooted	70.5239	71.8706	1.3467
	2311		Divided				1.0191
	2490			Ranked	194.527	195.08	1.00284
	2501		Subtracted				0.553
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	APPBP2	Divided	Measured	0.00001	0.00001	1
				Ranked
				Squared
				Rooted
			Subtracted	Measured	0	0	0
				Ranked
				Squared
				Rooted
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	1366	ANAPC11		Squared	53510.3	50671	2839.3
	2377			Rooted	75.9712	76.9809	1.0097
	2459		Divided				1.01329
	2521			Squared	53510.3	50671	1.05603
	2636			Ranked	195.635	195.384	1.00128
	2639		Subtracted				0.251
	2646			Measured	8936.97	8999.55	62.58
	2665		Divided				1.007
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	963	ANAPC10	Subtracted	Squared	24025.9	27585.7	3559.8
	1012		Divided				1.14817
	1612		Subtracted	Measured	6079.19	6503.12	423.93
	1647		Divided				1.06973
	2029		Subtracted	Rooted	65.822	67.511	1.689
	2089		Divided				1.02566
	2663			Ranked	204.768	204.549	1.00107
	2667		Subtracted				0.219
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	183	ANAPC2		Squared	69124.3	54897.4	14226.9
	326		Divided				1.25915
	657		Subtracted	Measured	10341.2	9630.35	710.85
	1518		Divided				1.07381
	2382		Subtracted	Rooted	81.0311	80.0375	0.9936
	2473		Divided				1.01241
	2679			Ranked	190.142	189.959	1.00096
	2682		Subtracted				0.183

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.