MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 2175 to 2224 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1088	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	High confidence	219.673	213.378	1.0295
	DEGS1	sphingolipid delta 4 desaturase; membrane fatty acid (lipid) desaturase; dihydroceramide desaturase. [refseq;acc:nm_003676]	Low confidence	203.333	198.607	1.0238
1089	CSTF3	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	High confidence	121.428	125.004	1.02945
	TRIB3	neuronal cell death inducible putative kinase (skip3). [swissprot;acc:q96ru7]	Low confidence	203.522	198.791	1.0238
1090	no value	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	High confidence	226.218	232.88	1.02945
	TRIB1	g-protein-coupled receptor induced protein. [refseq;acc:nm_025195]	Low confidence	203.52	198.79	1.02379
1091	no value	block 23. [sptrembl;acc:q8nhw5]	High confidence	226.205	232.858	1.02941
	CPT1C	carnitine palmitoyltransferase i related c. [refseq;acc:nm_152359]	Low confidence	203.519	198.789	1.02379
1092	EPHB1	ephrin type-b receptor 1 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-2) (net) (hek6) (elk). [swissprot;acc:p54762]		210.722	205.826
	RPLP0	60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	High confidence	226.203	232.855	1.02941
1093	COPA	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]		177.432	182.647	1.02939
	EPHA5	ephrin type-a receptor 5 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-1) (eph homology kinase-1) (receptor protein- tyrosine kinase hek7). [swissprot;acc:p54756]	Low confidence	210.722	205.826	1.02379
1094	ANXA7	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	High confidence	219.655	213.385	1.02938
	EPHA2	ephrin type-a receptor 2 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eck) (epithelial cell kinase). [swissprot;acc:p29317]	Low confidence	210.722	205.826	1.02379
1095	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	High confidence	213.552	207.463	1.02935
	SLC7A1	high-affinity cationic amino acid transporter-1 (cat-1) (cat1) (system y+ basic amino acid transporter) (ecotropic retroviral leukemia receptor homolog) (err) (ecotropic retrovirus receptor homolog). [swissprot;acc:p30825]	Low confidence	200.661	195.999	1.02379
1096	EPHA7	ephrin type-a receptor 7 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-3) (eph homology kinase-3) (receptor protein- tyrosine kinase hek11). [swissprot;acc:q15375]		210.722	205.826
	NDUFB9	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	High confidence	212.345	206.339	1.02911
1097	ATP2C2	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		209.123	203.208
	EPHB2	ephrin type-b receptor 2 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-3) (drt) (receptor protein-tyrosine kinase hek5) (erk). [swissprot;acc:p29323]	Low confidence	210.722	205.826	1.02379
1098	AP3M1	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	High confidence	217.323	211.185	1.02906
	EPHA4	ephrin type-a receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor sek) (receptor protein-tyrosine kinase hek8). [swissprot;acc:p54764]	Low confidence	210.722	205.826	1.02379
1099	AP3M2	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	High confidence	217.315	211.183	1.02904
	CPT1A	carnitine o-palmitoyltransferase i, mitochondrial liver isoform (ec 2.3.1.21) (cpt i) (cpti-l). [swissprot;acc:p50416]	Low confidence	203.519	198.789	1.02379
1100	no value	ephrin type-b receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor htk). [swissprot;acc:p54760]		210.722	205.826
	ATP2C1	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	High confidence	209.052	203.183	1.02889
1101	EPHB6	ephrin type-b receptor 6 precursor (tyrosine-protein kinase-defective receptor eph-6) (hep). [swissprot;acc:o15197]	Low confidence	210.722	205.826	1.02379
	KARS	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]	High confidence	220.291	226.584	1.02857
1102	no value	40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]		229.442	235.974	1.02847
	EPHA8	ephrin type-a receptor 8 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eek) (eph-and elk-related kinase) (hek3). [swissprot;acc:p29322]	Low confidence	210.722	205.826	1.02379
1103	EPHA3	ephrin type-a receptor 3 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor etk1) (hek) (hek4). [swissprot;acc:p29320]
	RPS27L	ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [refseq;acc:nm_015920]	High confidence	229.441	235.972	1.02846
1104	FZD8	frizzled 8 precursor (frizzled-8) (fz-8) (hfz8). [swissprot;acc:q9h461]	Low confidence	206.584	201.786	1.02378
	HAO1	hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	High confidence	231.922	238.486	1.0283
1105	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		191.139	185.882	1.02828
	TRIB2	tribbles homolog 2. [refseq;acc:nm_021643]	Low confidence	203.515	198.787	1.02378
1106	no value	mitochondrial carrier protein mgc4399. [refseq;acc:nm_032315]		201.02	196.352	1.02377
	PEX5L	pxr2b protein. [refseq;acc:nm_016559]	High confidence	212.945	207.109	1.02818
1107	RHCG	rh type c glycoprotein. [refseq;acc:nm_016321]	Low confidence	201.221	196.55	1.02376
	SPTLC2	serine palmitoyltransferase 2 (ec 2.3.1.50) (long chain base biosynthesis protein 2) (lcb 2) (serine-palmitoyl-coa transferase 2) (spt 2). [swissprot;acc:o15270]	High confidence	204.603	210.324	1.02796
1108	FOXK2	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]		218.006	212.119	1.02775
	VAPB	vesicle-associated membrane protein-associated protein b/c (vamp- associated protein b/c) (vamp-b/vamp-c) (vap-b/vap-c). [swissprot;acc:o95292]	Low confidence	204.27	199.529	1.02376
1109	MAPK13	mitogen-activated protein kinase 13 (ec 2.7.1.37) (stress-activated protein kinase-4) (mitogen-activated protein kinase p38 delta) (map kinase p38 delta). [swissprot;acc:o15264]		200.443	195.793	1.02375
	TPT1	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	High confidence	218.098	212.209	1.02775
1110	GIT2	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]		216.78	222.782	1.02769
	LBR	lamin b receptor (integral nuclear envelope inner membrane protein) (lmn2r). [swissprot;acc:q14739]	Low confidence	201.984	197.299	1.02375
1111	no value	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	High confidence	217.99	212.123	1.02766
	TM7SF2	delta(14)-sterol reductase (ec 1.3.1.70) (c-14 sterol reductase) (sterol c14-reductase) (delta14-sr) (transmembrane 7 superfamily member 2) (another new gene 1) (putative sterol reductase sr-1). [swissprot;acc:o76062]	Low confidence	202.004	197.323	1.02372
1112	HNF4G	hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	High confidence	251.863	258.829	1.02766
	VAPA	vesicle-associated membrane protein-associated protein a (vamp- associated protein a) (vamp-a) (vap-a) (33 kda vamp-associated protein) (vap-33). [swissprot;acc:q9p0l0]	Low confidence	204.256	199.524	1.02372

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.