MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2175 to 2224 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Value Type	red	green	network_comparison
544	rac-gamma serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-gamma) (protein kinase akt-3) (protein kinase b, gamma) (pkb gamma) (stk-2). [swissprot;acc:q9y243]	Measured	3889.27	4426.74	1.13819
	ran binding protein 11. [refseq;acc:nm_016338]	Squared	26018.9	30994.1	1.19121
545	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	Ranked	248.866	233.287	1.06678
	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	Rooted	66.082	71.6526	1.0843
	membrane protein expressed in epithelial-like lung adenocarcinoma. [refseq;acc:nm_024792]	Squared	26010	30981.7	1.19115
	rac-beta serine/threonine protein kinase (ec 2.7.1.-) (rac-pk-beta) (protein kinase akt-2) (protein kinase b, beta) (pkb beta). [swissprot;acc:p31751]	Measured	3889.27	4426.74	1.13819
546	atp synthase delta chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p30049]	Squared	27162.5	32347.5	1.19089
	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	Rooted	66.082	71.6526	1.0843
	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	Ranked	207.222	194.262	1.06671
	zinc finger protein t86. [swissprot;acc:o00488]	Measured	4052.77	4612.54	1.13812
547	gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]	Rooted	66.082	71.6525	1.0843
	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Ranked	207.26	194.346	1.06645
	s-adenosylmethionine synthetase gamma form (ec 2.5.1.6) (methionine adenosyltransferase) (adomet synthetase) (mat-ii). [swissprot;acc:p31153]	Squared	25945.4	30892.3	1.19067
	werner helicase interacting protein isoform 1; putative helicase ruvbl; werner helicase interacting protein. [refseq;acc:nm_020135]	Measured	5291.92	6020.19	1.13762
548	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		8268.19	9405.85	1.13759
	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	Rooted	66.082	71.6525	1.0843
	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]	Ranked	207.26	194.346	1.06645
	vesicle-associated membrane protein 2 (vamp-2) (synaptobrevin 2). [swissprot;acc:p19065]	Squared	27516.2	32720	1.18912
549	dolichol-phosphate mannosyltransferase (ec 2.4.1.83) (dolichol- phosphate mannose synthase) (dolichyl-phosphate beta-d- mannosyltransferase) (mannose-p-dolichol synthase) (mpd synthase) (dpm synthase). [swissprot;acc:o60762]	Measured	5865.79	6671.23	1.13731
	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	Rooted	66.082	71.6526	1.0843
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Ranked	207.26	194.346	1.06645
	vesicle-associated membrane protein 1 (vamp-1) (synaptobrevin 1). [swissprot;acc:p23763]	Squared	27516.2	32720	1.18912
550	gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]	Rooted	66.082	71.6525	1.0843
	prohibitin. [swissprot;acc:p35232]	Measured	5773.45	6563.69	1.13687
	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]	Ranked	207.26	194.346	1.06645
	vesicule-associated membrane protein 4 (vamp-4). [swissprot;acc:o75379]	Squared	27516.2	32720	1.18912
551	cdp-diacylglycerol--inositol 3-phosphatidyltransferase (ec 2.7.8.11) (phosphatidylinositol synthase) (ptdins synthase) (pi synthase). [swissprot;acc:o14735]
	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	Rooted	66.082	71.6525	1.0843
	grb2-related adaptor protein 2 (gads protein) (growth factor receptor binding protein) (grblg) (grf40 adaptor protein) (grf-40) (grb-2-like protein) (grb2l) (grbx) (p38) (hematopoietic cell-associated adaptor protein grpl) (adapter protein grid) (sh3-sh2-sh3 adaptor mona). [swissprot;acc:o75791]	Ranked	207.261	194.347	1.06645
	repressor of estrogen receptor activity; b-cell associated protein. [refseq;acc:nm_007273]	Measured	5773.45	6563.69	1.13687
552	adp-ribosylation factor gtpase activating protein 1 (adp-ribosylation factor 1 gtpase activating protein) (arf1 gap) (arf1-directed gtpase- activating protein) (gap protein). [swissprot;acc:q8n6t3]	Squared	27516.2	32720	1.18912
	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Measured	15427.2	13572.8	1.13663
	crk-like protein. [swissprot;acc:p46109]	Ranked	207.26	194.346	1.06645
	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	Rooted	66.082	71.6523	1.08429
553	proto-oncogene tyrosine-protein kinase abl1 (ec 2.7.1.112) (p150) (c-abl). [swissprot;acc:p00519]	Ranked	207.26	194.346	1.06645
	similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]	Rooted	66.082	71.6523	1.08429
	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	Measured	3853.64	4379.71	1.13651
	vesicle-associated membrane protein 3 (vamp-3) (synaptobrevin 3) (cellubrevin) (ceb). [swissprot;acc:q15836]	Squared	27516.2	32720	1.18912
554	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	Rooted	66.0829	71.6462	1.08419
	pre-mrna cleavage complex ii protein clp1. [swissprot;acc:q92989]	Measured	14830.5	13050.3	1.13641
	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Squared	8426.68	10010.8	1.18799
	proto-oncogene tyrosine-protein kinase fyn (ec 2.7.1.112) (p59-fyn) (syn) (slk). [swissprot;acc:p06241]	Ranked	207.26	194.346	1.06645
555	proto-oncogene tyrosine-protein kinase fgr (ec 2.7.1.112) (p55-fgr) (c-fgr). [swissprot;acc:p09769]
	s-phase kinase-associated protein 1a (cyclin a/cdk2-associated protein p19) (p19a) (p19skp1) (rna polymerase ii elongation factor-like protein) (organ of corti protein 2) (ocp-ii protein) (ocp-2) (transcription elongation factor b) (siii). [swissprot;acc:p34991]	Squared	8426.68	10010.8	1.18799
	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Measured	6167.93	7007.7	1.13615
	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Rooted	59.7823	64.7895	1.08376
556	ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	Ranked	207.27	194.368	1.06638
	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Squared	8426.68	10010.8	1.18799
	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Measured	6167.93	7007.7	1.13615
	signal transduction protein cbl-b (sh3-binding protein cbl-b). [swissprot;acc:q13191]	Rooted	66.0911	71.6061	1.08345

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.