MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2175 to 2224 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1088	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	Divided	219.673	213.378	1.0295
	PEX5L	pxr2b protein. [refseq;acc:nm_016559]	Subtracted	212.945	207.109	5.836
1089	ATP6V0D2	atpase, h+ transporting, lysosomal 38kda, v0 subunit d isoform 2. [refseq;acc:nm_152565]		218.487	212.656	5.831
	CSTF3	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	Divided	121.428	125.004	1.02945
1090	no value	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]		226.218	232.88
	NCALD	neurocalcin delta. [swissprot;acc:p29554]	Subtracted	225.104	230.931	5.827
1091	no value	block 23. [sptrembl;acc:q8nhw5]	Divided	226.205	232.858	1.02941
	HPCA	neuron specific calcium-binding protein hippocalcin (p23k) (calcium- binding protein bdr-2). [swissprot;acc:p32076]	Subtracted	225.103	230.928	5.825
1092	HPCAL1	visinin-like protein 3 (vilip-3) (calcium-binding protein bdr-1) (hlp2) (hippocalcin-like protein 1). [swissprot;acc:p37235]		225.094	230.913	5.819
	RPLP0	60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	Divided	226.203	232.855	1.02941
1093	no value	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	Subtracted	218.484	212.675	5.809
	COPA	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]	Divided	177.432	182.647	1.02939
1094	ANXA7	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]		219.655	213.385	1.02938
	API5	apoptosis inhibitor 5; fibroblast growth factor 2-interacting factor 2; api5-like 1. [refseq;acc:nm_006595]	Subtracted	218.484	212.675	5.809
1095	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Divided	213.552	207.463	1.02935
	SEC13	sec13-related protein. [swissprot;acc:p55735]	Subtracted	218.484	212.675	5.809
1096	ATP6V1G3	vacuolar atp synthase subunit g 3 (ec 3.6.3.14) (v-atpase g subunit 3) (vacuolar proton pump g subunit 3) (v-atpase 13 kda subunit 3). [swissprot;acc:q96lb4]
	NDUFB9	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	Divided	212.345	206.339	1.02911
1097	ATP2C2	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		209.123	203.208
	ATP6V1B2	vacuolar atp synthase subunit b, brain isoform (ec 3.6.3.14) (v-atpase b2 subunit) (vacuolar proton pump b isoform 2) (endomembrane proton pump 58 kda subunit) (ho57). [swissprot;acc:p21281]	Subtracted	218.484	212.675	5.809
1098	AP3M1	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	Divided	217.323	211.185	1.02906
	SEC31A	yeast sec31p homolog. [refseq;acc:nm_014933]	Subtracted	218.484	212.675	5.809
1099	AP3M2	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	Divided	217.315	211.183	1.02904
	ATP6V1G1	vacuolar atp synthase subunit g 1 (ec 3.6.3.14) (v-atpase g subunit 1) (vacuolar proton pump g subunit 1) (v-atpase 13 kda subunit 1) (vacuolar atp synthase subunit m16). [swissprot;acc:o75348]	Subtracted	218.484	212.675	5.809
1100	ATP2C1	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	Divided	209.052	203.183	1.02889
	ATP6V1E1	vacuolar atp synthase subunit e (ec 3.6.3.14) (v-atpase e subunit) (vacuolar proton pump e subunit) (v-atpase 31 kda subunit) (p31). [swissprot;acc:p36543]	Subtracted	218.484	212.675	5.809
1101	GDAP1L1	ganglioside-induced differentiation-associated protein 1-like 1. [refseq;acc:nm_024034]
	KARS	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]	Divided	220.291	226.584	1.02857
1102	no value	40s ribosomal protein s27 (metallopan-stimulin 1) (mps-1). [swissprot;acc:p42677]		229.442	235.974	1.02847
	DDX39	dead (asp-glu-ala-asp) box polypeptide 39 isoform 1; nuclear rna helicase, decd variant of dead box family. [refseq;acc:nm_005804]	Subtracted	218.484	212.675	5.809
1103	GDAP1	ganglioside-induced differentiation-associated protein 1. [refseq;acc:nm_018972]
	RPS27L	ribosomal protein s27-like protein; 40s ribosomal protein s27 isoform. [refseq;acc:nm_015920]	Divided	229.441	235.972	1.02846
1104	ATP6V1D	vacuolar atp synthase subunit d (ec 3.6.3.14) (v-atpase d subunit) (vacuolar proton pump d subunit) (v-atpase 28 kda accessory protein). [swissprot;acc:q9y5k8]	Subtracted	218.484	212.675	5.809
	HAO1	hydroxyacid oxidase 1 (ec 1.1.3.15) (haox1) (glycolate oxidase) (gox). [swissprot;acc:q9ujm8]	Divided	231.922	238.486	1.0283
1105	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]		191.139	185.882	1.02828
	SEC31B	secretory pathway component sec31b-1. [refseq;acc:nm_015490]	Subtracted	218.484	212.675	5.809
1106	ATP6V1H	vacuolar atp synthase subunit h (ec 3.6.3.14) (v-atpase h subunit) (vacuolar proton pump h subunit) (v-atpase 50/57 kda subunits) (vacuolar proton pump subunit sfd) (cgi-11). [swissprot;acc:q9ui12]
	PEX5L	pxr2b protein. [refseq;acc:nm_016559]	Divided	212.945	207.109	1.02818
1107	ATP6V1B1	vacuolar atp synthase subunit b, kidney isoform (ec 3.6.3.14) (v- atpase b1 subunit) (vacuolar proton pump b isoform 1) (endomembrane proton pump 58 kda subunit). [swissprot;acc:p15313]	Subtracted	218.483	212.676	5.807
	SPTLC2	serine palmitoyltransferase 2 (ec 2.3.1.50) (long chain base biosynthesis protein 2) (lcb 2) (serine-palmitoyl-coa transferase 2) (spt 2). [swissprot;acc:o15270]	Divided	204.603	210.324	1.02796
1108	ATP6V1F	vacuolar atp synthase subunit f (ec 3.6.3.14) (v-atpase f subunit) (vacuolar proton pump f subunit) (v-atpase 14 kda subunit). [swissprot;acc:q16864]	Subtracted	218.481	212.675	5.806
	FOXK2	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]	Divided	218.006	212.119	1.02775
1109	EPS8L1	epidermal growth factor receptor pathway substrate 8-like protein 1 isoform c; epidermal growth factor receptor pathway substrate 8-related protein 1; eps8-related protein 1. [refseq;acc:nm_139204]	Subtracted	221.939	216.143	5.796
	TPT1	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	Divided	218.098	212.209	1.02775
1110	BHLHB4	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	Subtracted	159.13	164.917	5.787
	GIT2	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	Divided	216.78	222.782	1.02769
1111	no value	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]		217.99	212.123	1.02766
	BHLHB5	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	Subtracted	159.165	164.951	5.786
1112	EPS8	epidermal growth factor receptor kinase substrate eps8. [swissprot;acc:q12929]		221.93	216.146	5.784
	HNF4G	hepatocyte nuclear factor 4-gamma (hnf-4-gamma). [swissprot;acc:q14541]	Divided	251.863	258.829	1.02766

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.