MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1076	COPZ1	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	High confidence	174.387	179.697	1.03045
	SGCZ	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Low confidence	206.757	201.939	1.02386
1077	ARCN1	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	High confidence	174.387	179.697	1.03045
	FZD5	frizzled 5 precursor (frizzled-5) (fz-5) (hfz5) (fze5). [swissprot;acc:q13467]	Low confidence	206.587	201.773	1.02386
1078	KDELR2	er lumen protein retaining receptor 2 (kdel receptor 2) (elp-1). [swissprot;acc:p33947]		202.92	198.191
	PPIE	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	High confidence	174.387	179.697	1.03045
1079	COPZ2	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	KDELR1	er lumen protein retaining receptor 1 (kdel receptor 1). [swissprot;acc:p24390]	Low confidence	202.92	198.191	1.02386
1080	BRP44L	brain protein 44-like protein (hspc040) (cgi-129) (pnas-115). [swissprot;acc:q9y5u8]		196.378	191.803	1.02385
	ZNF444	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	High confidence	269.896	278.093	1.03037
1081	EIF3C	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	Low confidence	202.98	198.253	1.02384
	FAU	40s ribosomal protein s30. [swissprot;acc:q05472]	High confidence	223.44	216.875	1.03027
1082	HDC	histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	Low confidence	203.804	199.058	1.02384
	PLEKHF2	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	High confidence	220.118	213.685	1.03011
1083	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
	TPPP2	protein p25-beta. [swissprot;acc:p59282]	Low confidence	203.939	199.193	1.02383
1084	ELOVL6	elovl family member 6, elongation of long chain fatty acids (fen1/elo2, sur4/elo3-like, yeast); long-chain fatty-acyl elongase. [refseq;acc:nm_024090]		200.38	195.716
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	High confidence	220.118	213.685	1.03011
1085	DKC1	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]		231.007	237.864	1.02968
	TPPP	25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	Low confidence	203.933	199.188	1.02382
1086	no value	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	High confidence	236.679	243.679	1.02958
	TPPP3	protein cgi-38. [swissprot;acc:q9bw30]	Low confidence	203.9	199.157	1.02382
1087	no value	zinc finger protein 277. [swissprot;acc:q9nrm2]	High confidence	236.679	243.679	1.02958
	PERLD1	cab2. [refseq;acc:nm_033419]	Low confidence	200.375	195.715	1.02381
1088	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	High confidence	219.673	213.378	1.0295
	DEGS1	sphingolipid delta 4 desaturase; membrane fatty acid (lipid) desaturase; dihydroceramide desaturase. [refseq;acc:nm_003676]	Low confidence	203.333	198.607	1.0238
1089	CSTF3	cleavage stimulation factor subunit 3; cleavage stimulation factor, 3' pre-rna, subunit 3, 77kd. [refseq;acc:nm_001326]	High confidence	121.428	125.004	1.02945
	TRIB3	neuronal cell death inducible putative kinase (skip3). [swissprot;acc:q96ru7]	Low confidence	203.522	198.791	1.0238
1090	no value	similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	High confidence	226.218	232.88	1.02945
	TRIB1	g-protein-coupled receptor induced protein. [refseq;acc:nm_025195]	Low confidence	203.52	198.79	1.02379
1091	no value	block 23. [sptrembl;acc:q8nhw5]	High confidence	226.205	232.858	1.02941
	CPT1C	carnitine palmitoyltransferase i related c. [refseq;acc:nm_152359]	Low confidence	203.519	198.789	1.02379
1092	EPHB1	ephrin type-b receptor 1 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-2) (net) (hek6) (elk). [swissprot;acc:p54762]		210.722	205.826
	RPLP0	60s acidic ribosomal protein p0 (l10e). [swissprot;acc:p05388]	High confidence	226.203	232.855	1.02941
1093	COPA	coatomer alpha subunit (alpha-coat protein) (alpha-cop) (hepcop) (hep-cop) [contains: xenin (xenopsin-related peptide); proxenin]. [swissprot;acc:p53621]		177.432	182.647	1.02939
	EPHA5	ephrin type-a receptor 5 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-1) (eph homology kinase-1) (receptor protein- tyrosine kinase hek7). [swissprot;acc:p54756]	Low confidence	210.722	205.826	1.02379
1094	ANXA7	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	High confidence	219.655	213.385	1.02938
	EPHA2	ephrin type-a receptor 2 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eck) (epithelial cell kinase). [swissprot;acc:p29317]	Low confidence	210.722	205.826	1.02379
1095	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	High confidence	213.552	207.463	1.02935
	SLC7A1	high-affinity cationic amino acid transporter-1 (cat-1) (cat1) (system y+ basic amino acid transporter) (ecotropic retroviral leukemia receptor homolog) (err) (ecotropic retrovirus receptor homolog). [swissprot;acc:p30825]	Low confidence	200.661	195.999	1.02379
1096	EPHA7	ephrin type-a receptor 7 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor ehk-3) (eph homology kinase-3) (receptor protein- tyrosine kinase hek11). [swissprot;acc:q15375]		210.722	205.826
	NDUFB9	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	High confidence	212.345	206.339	1.02911
1097	ATP2C2	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		209.123	203.208
	EPHB2	ephrin type-b receptor 2 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor eph-3) (drt) (receptor protein-tyrosine kinase hek5) (erk). [swissprot;acc:p29323]	Low confidence	210.722	205.826	1.02379
1098	AP3M1	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	High confidence	217.323	211.185	1.02906
	EPHA4	ephrin type-a receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor sek) (receptor protein-tyrosine kinase hek8). [swissprot;acc:p54764]	Low confidence	210.722	205.826	1.02379
1099	AP3M2	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	High confidence	217.315	211.183	1.02904
	CPT1A	carnitine o-palmitoyltransferase i, mitochondrial liver isoform (ec 2.3.1.21) (cpt i) (cpti-l). [swissprot;acc:p50416]	Low confidence	203.519	198.789	1.02379
1100	no value	ephrin type-b receptor 4 precursor (ec 2.7.1.112) (tyrosine-protein kinase receptor htk). [swissprot;acc:p54760]		210.722	205.826
	ATP2C1	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	High confidence	209.052	203.183	1.02889

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.