MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2151 to 2200 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
538	POLR2L	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	Divided	High confidence	237.627	253.604	1.06724
	RANBP9	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	Subtracted	Low confidence	203.519	197.195	6.324
539	CRBN	protein x 0001. [refseq;acc:nm_016302]	Divided		199.661	193.489	1.0319
	MEMO1P	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]		High confidence	236.964	252.86	1.06708
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Subtracted	Low confidence	206.737	200.417	6.32
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]		High confidence	112	126	14
540	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]		Low confidence	206.737	200.417	6.32
	PANK3	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		High confidence	58	44	14
	SEPHS2	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
541	AP1M2	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	Subtracted		205.768	199.453	6.315
	MICAL2	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Divided	High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	High confidence	112	126	14
542	INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	High confidence	112	126	14
	SART1	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]		Low confidence	200.271	193.957	6.314
543	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]		High confidence	112	126	14
	AP1M1	adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]		Low confidence	205.75	199.452	6.298
	SEPHS1	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
544	INPP4A	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]		High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	MYH7B	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Subtracted	High confidence	112	126	14
	NUTF2	nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [swissprot;acc:p13662]		Low confidence	205.57	199.279	6.291
545	EIF6	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	Divided	High confidence	248.866	233.287	1.06678
	RPUSD2	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]		Low confidence	202.949	196.678	1.03188
	SESN3	sestrin 3. [swissprot;acc:p58005]	Subtracted		203.305	197.023	6.282
	SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]		High confidence	58	44	14
546	MYH13	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]			112	126
	SESN2	sestrin 2 (hi95). [swissprot;acc:p58004]		Low confidence	203.306	197.024	6.282
	TMBIM4	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Divided		202.949	196.678	1.03188
	WAS	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]		High confidence	207.222	194.262	1.06671
547	AARS	alanyl-trna synthetase (ec 6.1.1.7) (alanine--trna ligase) (alars). [swissprot;acc:p49588]	Subtracted		234.106	248.104	13.998
	CRK	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	Divided		207.26	194.346	1.06645
	FLOT1	flotillin-1. [swissprot;acc:o75955]	Subtracted	Low confidence	203.303	197.022	6.281
	SESN3	sestrin 3. [swissprot;acc:p58005]	Divided		203.305	197.023	1.03188
548	ABL2	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]		High confidence	207.26	194.346	1.06645
	FLOT1	flotillin-1. [swissprot;acc:o75955]		Low confidence	203.303	197.022	1.03188
	SEPHS2	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Subtracted	High confidence	222.156	208.201	13.955
	SESN1	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]		Low confidence	203.299	197.018	6.281
549	no value	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Divided	High confidence	207.26	194.346	1.06645
	MICAL2	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Subtracted		222.156	208.201	13.955
	RPUSD2	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]		Low confidence	202.949	196.678	6.271
	SESN2	sestrin 2 (hi95). [swissprot;acc:p58004]	Divided		203.306	197.024	1.03188
550	HCK	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]		High confidence	207.26	194.346	1.06645
	INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Subtracted		222.156	208.201	13.955
	SESN1	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	Divided	Low confidence	203.299	197.018	1.03188
	TMBIM4	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	Subtracted		202.949	196.678	6.271

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.