MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Network Comparison Type	Value Type	Hugo	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2130 to 2179 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Interaction Map	red	green	network_comparison
533	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	Divided	SLC45A2	High confidence	250.942	235.004	1.06782
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Subtracted	SEPHS1	Low confidence	206.406	200.027	6.379
	solute carrier family 2, facilitated glucose transporter, member 1 (glucose transporter type 1, erythrocyte/brain) (hepg2 glucose transporter). [swissprot;acc:p11166]	Divided	SLC2A1		205.533	199.112	1.03225
534	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]		no value	High confidence	250.942	235.004	1.06782
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Subtracted	INPP4A	Low confidence	206.406	200.027	6.379
	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		PANK1	High confidence	58	44	14
	zinc finger protein 216. [swissprot;acc:o76080]	Divided	ZFAND5	Low confidence	184.361	178.613	1.03218
535	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]		POLR2H	High confidence	236.662	252.708	1.0678
	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Subtracted	HTATSF1	Low confidence	209.347	202.978	6.369
	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]		MYH4	High confidence	112	126	14
	protein associated with prk1. [refseq;acc:nm_019006]	Divided	ZFAND6	Low confidence	184.361	178.613	1.03218
536	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]		SSB	High confidence	242.531	227.136	1.06778
	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Subtracted	MYH8		112	126	14
	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	Divided	RANBP9	Low confidence	203.519	197.195	1.03207
	ring finger protein 7; sensitive to apoptosis gene. [refseq;acc:nm_014245]	Subtracted	RNF7		203.162	196.796	6.366
537	megf11 protein. [refseq;acc:nm_032445]	Divided	MEGF11		207.951	201.517	1.03193
	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Subtracted	ATP9A		202.845	209.189	6.344
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]		UBAC1	High confidence	10	24	14
	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	Divided	DHX15		229.803	215.301	1.06736
538	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]		POLR2L		237.627	253.604	1.06724
	megf10 protein. [refseq;acc:nm_032446]		MEGF10	Low confidence	207.949	201.517	1.03192
	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Subtracted	PANK2	High confidence	58	44	14
	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]		RANBP9	Low confidence	203.519	197.195	6.324
539	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]		MYH2	High confidence	112	126	14
	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]		MOBKL3	Low confidence	206.737	200.417	6.32
	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	Divided	MEMO1P	High confidence	236.964	252.86	1.06708
	protein x 0001. [refseq;acc:nm_016302]		CRBN	Low confidence	199.661	193.489	1.0319
540	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]	Subtracted	DNAJB11		206.737	200.417	6.32
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		PANK3	High confidence	58	44	14
	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided	SEPHS2		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
541	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	Subtracted	AP1M2		205.768	199.453	6.315
	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Divided	MICAL2	High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	MYH3	High confidence	112	126	14
542	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided	INPP4B		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	MYH1	High confidence	112	126	14
	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]		SART1	Low confidence	200.271	193.957	6.314
543	adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]		AP1M1		205.75	199.452	6.298
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]		no value	High confidence	112	126	14
	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	SEPHS1		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
544	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	Subtracted	MYH7B	High confidence	112	126	14
	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Divided	INPP4A		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	nuclear transport factor 2 (ntf-2) (placental protein 15) (pp15). [swissprot;acc:p13662]	Subtracted	NUTF2		205.57	199.279	6.291
545	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]	Divided	RPUSD2		202.949	196.678	1.03188
	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]		EIF6	High confidence	248.866	233.287	1.06678
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	Subtracted	SLC25A43		58	44	14

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.