MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2125 to 2174 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
1063	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Subtracted	126.215	120.078	6.137
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	no value	Divided	269.96	278.232	1.03064
1064	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	AP3M2	Subtracted	217.315	211.183	6.132
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	ZNF24	Divided	269.955	278.221	1.03062
1065	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10	Subtracted	125.526	119.402	6.124
	zinc finger protein 305. [swissprot;acc:o43309]	ZSCAN12	Divided	269.954	278.219	1.03062
1066	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	SEPT8	Subtracted	124.434	118.318	6.116
	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	ZNF18	Divided	269.956	278.223	1.03062
1067	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	GTPBP3	Subtracted	213.552	207.463	6.089
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	ZNF215	Divided	269.956	278.223	1.03062
1068	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	NDUFB9	Subtracted	212.345	206.339	6.006
	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	ZNF274	Divided	269.953	278.215	1.03061
1069	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	DPH1	Subtracted	229.243	235.246	6.003
	zinc finger protein 232. [swissprot;acc:q9uny5]	ZNF232	Divided	269.954	278.218	1.03061
1070	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	GIT2	Subtracted	216.78	222.782	6.002
	zinc finger protein 99. [refseq;acc:nm_032164]	ZNF394	Divided	269.954	278.218	1.03061
1071	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]	no value		231.277	238.356
	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	MPHOSPH10	Subtracted	241.496	235.508	5.988
1072	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]	PPA1		224.307	230.242	5.935
	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	ZNF213	Divided	269.954	278.217	1.03061
1073	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	PPA2	Subtracted	224.307	230.242	5.935
	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	WBP2	Divided	216.901	210.485	1.03048
1074	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	AIPL1	Subtracted	224.307	230.242	5.935
	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	COPB2	Divided	174.387	179.697	1.03045
1075	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	AIP	Subtracted	224.307	230.242	5.935
	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	COPG	Divided	174.387	179.697	1.03045
1076	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	COPZ1
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	ATP2C2	Subtracted	209.123	203.208	5.915
1077	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	ARCN1	Divided	174.387	179.697	1.03045
	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	TPT1	Subtracted	218.098	212.209	5.889
1078	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]	FOXK2		218.006	212.119	5.887
	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	PPIE	Divided	174.387	179.697	1.03045
1079	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]	COPZ2
	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	SIX1	Subtracted	221.286	215.399	5.887
1080	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]	PA2G4		221.285	215.4	5.885
	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	ZNF444	Divided	269.896	278.093	1.03037
1081	40s ribosomal protein s30. [swissprot;acc:q05472]	FAU		223.44	216.875	1.03027
	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	SIX2	Subtracted	221.285	215.401	5.884
1082	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]	ATP2C1		209.052	203.183	5.869
	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	PLEKHF2	Divided	220.118	213.685	1.03011
1083	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	SRD5A1
	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	no value	Subtracted	217.99	212.123	5.867
1084	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	SRD5A2	Divided	220.118	213.685	1.03011
	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	ATP6V0A1	Subtracted	218.529	212.676	5.853
1085	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	DKC1	Divided	231.007	237.864	1.02968
	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	ATP6V0A2	Subtracted	218.528	212.676	5.852
1086	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	ATP6V0A4
	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	no value	Divided	236.679	243.679	1.02958
1087	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	TCIRG1	Subtracted	218.527	212.676	5.851
	zinc finger protein 277. [swissprot;acc:q9nrm2]	no value	Divided	236.679	243.679	1.02958

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.