MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2125 to 2174 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1063	no value	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	Divided	269.96	278.232	1.03064
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	126.215	120.078	6.137
1064	AP3M2	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]		217.315	211.183	6.132
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Divided	269.955	278.221	1.03062
1065	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	125.526	119.402	6.124
	ZSCAN12	zinc finger protein 305. [swissprot;acc:o43309]	Divided	269.954	278.219	1.03062
1066	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	124.434	118.318	6.116
	ZNF18	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Divided	269.956	278.223	1.03062
1067	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Subtracted	213.552	207.463	6.089
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Divided	269.956	278.223	1.03062
1068	NDUFB9	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	Subtracted	212.345	206.339	6.006
	ZNF274	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Divided	269.953	278.215	1.03061
1069	DPH1	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	Subtracted	229.243	235.246	6.003
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	Divided	269.954	278.218	1.03061
1070	GIT2	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	Subtracted	216.78	222.782	6.002
	ZNF394	zinc finger protein 99. [refseq;acc:nm_032164]	Divided	269.954	278.218	1.03061
1071	no value	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]		231.277	238.356
	MPHOSPH10	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	Subtracted	241.496	235.508	5.988
1072	PPA1	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]		224.307	230.242	5.935
	ZNF213	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Divided	269.954	278.217	1.03061
1073	PPA2	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	Subtracted	224.307	230.242	5.935
	WBP2	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	Divided	216.901	210.485	1.03048
1074	AIPL1	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	Subtracted	224.307	230.242	5.935
	COPB2	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	Divided	174.387	179.697	1.03045
1075	AIP	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	Subtracted	224.307	230.242	5.935
	COPG	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	Divided	174.387	179.697	1.03045
1076	ATP2C2	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]	Subtracted	209.123	203.208	5.915
	COPZ1	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]	Divided	174.387	179.697	1.03045
1077	ARCN1	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]
	TPT1	translationally controlled tumor protein (tctp) (p23) (histamine- releasing factor) (hrf). [swissprot;acc:p13693]	Subtracted	218.098	212.209	5.889
1078	FOXK2	interleukin enhancer-binding factor 1 (cellular transcription factor ilf-1). [swissprot;acc:q01167]		218.006	212.119	5.887
	PPIE	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	Divided	174.387	179.697	1.03045
1079	COPZ2	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	SIX1	homeobox protein six1 (sine oculis homeobox homolog 1). [swissprot;acc:q15475]	Subtracted	221.286	215.399	5.887
1080	PA2G4	proliferation-associated protein 2g4 (cell cycle protein p38-2g4 homolog) (hg4-1). [swissprot;acc:q9uq80]		221.285	215.4	5.885
	ZNF444	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	Divided	269.896	278.093	1.03037
1081	FAU	40s ribosomal protein s30. [swissprot;acc:q05472]		223.44	216.875	1.03027
	SIX2	homeobox protein six2 (sine oculis homeobox homolog 2). [swissprot;acc:q9npc8]	Subtracted	221.285	215.401	5.884
1082	ATP2C1	calcium-transporting atpase type 2c, member 1 (ec 3.6.3.8) (atpase 2c1) (atp-dependent ca(2+) pump pmr1) (hussy-28). [swissprot;acc:p98194]		209.052	203.183	5.869
	PLEKHF2	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	Divided	220.118	213.685	1.03011
1083	no value	apoptosis inhibitor fksg2. [swissprot;acc:q9hau6]	Subtracted	217.99	212.123	5.867
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]	Divided	220.118	213.685	1.03011
1084	ATP6V0A1	vacuolar proton translocating atpase 116 kda subunit a isoform 1 (clathrin-coated vesicle/synaptic vesicle proton pump 116 kda subunit) (vacuolar proton pump subunit 1) (vacuolar adenosine triphosphatase subunit ac116). [swissprot;acc:q93050]	Subtracted	218.529	212.676	5.853
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	Divided	220.118	213.685	1.03011
1085	ATP6V0A2	vacuolar proton translocating atpase 116 kda subunit a isoform 2 (v-atpase 116-kda isoform a2) (tj6). [swissprot;acc:q9y487]	Subtracted	218.528	212.676	5.852
	DKC1	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]	Divided	231.007	237.864	1.02968
1086	no value	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]		236.679	243.679	1.02958
	ATP6V0A4	atpase, h+ transporting, lysosomal v0 subunit a isoform 4; vacuolar proton pump 116 kda accessory subunit; vacuolar proton pump, subunit 2; h(+)-transporting two-sector atpase, noncatalytic accessory protein 1b; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1b; renal tubular acidosis; atpase, h+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kd). [refseq;acc:nm_020632]	Subtracted	218.528	212.676	5.852
1087	no value	zinc finger protein 277. [swissprot;acc:q9nrm2]	Divided	236.679	243.679	1.02958
	TCIRG1	vacuolar proton translocating atpase 116 kda subunit a isoform 3 (v- atpase 116-kda isoform a3) (osteoclastic proton pump 116 kda subunit) (oc-116 kda) (oc116) (t-cell immune regulator 1) (t cell immune response cdna7 protein) (tirc7). [swissprot;acc:q13488]	Subtracted	218.527	212.676	5.851

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.