MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2125 to 2174 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
1063	no value	t-cell activation protein phosphatase 2c. [refseq;acc:nm_139283]	Low confidence	203.048	198.295	1.02397
		zinc finger imprinted 2. [swissprot;acc:q9nzv7]	High confidence	269.96	278.232	1.03064
1064	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]	Low confidence	201.995	197.269	1.02396
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	High confidence	269.955	278.221	1.03062
1065	ABCF2	atp-binding cassette, sub-family f, member 2 (iron inhibited abc transporter 2) (hussy-18). [swissprot;acc:q9ug63]	Low confidence	201.115	196.411	1.02395
	ZSCAN12	zinc finger protein 305. [swissprot;acc:o43309]	High confidence	269.954	278.219	1.03062
1066	YPEL2	yippee-like protein 2 (digeorge syndrome-related protein fksg4). [swissprot;acc:q96qa6]	Low confidence	187.762	183.372	1.02394
	ZNF18	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	High confidence	269.956	278.223	1.03062
1067	YPEL4	yippee-like protein 5. [swissprot;acc:q96ns1]	Low confidence	187.77	183.38	1.02394
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	High confidence	269.956	278.223	1.03062
1068	UTP3	disrupter of silencing 10. [refseq;acc:nm_020368]	Low confidence	199.958	195.283	1.02394
	ZNF274	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	High confidence	269.953	278.215	1.03061
1069	YPEL3	yippee-like protein 3 (digeorge syndrome-related protein fksg5). [swissprot;acc:q9bsj4]	Low confidence	187.761	183.371	1.02394
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	High confidence	269.954	278.218	1.03061
1070	SH3GL2	sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962]	Low confidence	203.828	199.067	1.02392
	ZNF394	zinc finger protein 99. [refseq;acc:nm_032164]	High confidence	269.954	278.218	1.03061
1071	no value	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]		231.277	238.356
	TRIT1	trna isopentenylpyrophosphate transferase. [refseq;acc:nm_017646]	Low confidence	200.19	195.515	1.02391
1072	RWDD1	rwd domain containing 1; ptd013 protein; cgi-24 protein. [refseq;acc:nm_015952]		203.286	198.543	1.02389
	ZNF213	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	High confidence	269.954	278.217	1.03061
1073	HNRPUL1	e1b-55kda-associated protein 5 isoform a. [refseq;acc:nm_007040]	Low confidence	210.723	205.809	1.02388
	WBP2	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	High confidence	216.901	210.485	1.03048
1074	COPB2	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]		174.387	179.697	1.03045
	FDX1	adrenodoxin, mitochondrial precursor (adrenal ferredoxin) (hepatoredoxin) (ferredoxin 1). [swissprot;acc:p10109]	Low confidence	191.57	187.103	1.02387
1075	no value	adenosine deaminase (ec 3.5.4.4) (adenosine aminohydrolase). [swissprot;acc:p00813]		202.317	197.601
	COPG	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	High confidence	174.387	179.697	1.03045
1076	COPZ1	coatomer zeta-1 subunit (zeta-1 coat protein) (zeta-1 cop) (cgi-120) (hspc181). [swissprot;acc:q9y3c3]
	SGCZ	sarcoglycan zeta; zeta-sarcoglycan. [refseq;acc:nm_139167]	Low confidence	206.757	201.939	1.02386
1077	ARCN1	coatomer delta subunit (delta-coat protein) (delta-cop) (archain). [swissprot;acc:p48444]	High confidence	174.387	179.697	1.03045
	FZD5	frizzled 5 precursor (frizzled-5) (fz-5) (hfz5) (fze5). [swissprot;acc:q13467]	Low confidence	206.587	201.773	1.02386
1078	KDELR2	er lumen protein retaining receptor 2 (kdel receptor 2) (elp-1). [swissprot;acc:p33947]		202.92	198.191
	PPIE	peptidyl-prolyl cis-trans isomerase e (ec 5.2.1.8) (ppiase e) (rotamase e) (cyclophilin e) (cyclophilin 33). [swissprot;acc:q9unp9]	High confidence	174.387	179.697	1.03045
1079	COPZ2	coatomer zeta-2 subunit (zeta-2 coat protein) (zeta-2 cop). [swissprot;acc:q9p299]
	KDELR1	er lumen protein retaining receptor 1 (kdel receptor 1). [swissprot;acc:p24390]	Low confidence	202.92	198.191	1.02386
1080	BRP44L	brain protein 44-like protein (hspc040) (cgi-129) (pnas-115). [swissprot;acc:q9y5u8]		196.378	191.803	1.02385
	ZNF444	zinc finger protein 444; endothelial zinc finger protein 2. [refseq;acc:nm_018337]	High confidence	269.896	278.093	1.03037
1081	EIF3C	eukaryotic translation initiation factor 3 subunit 8 (eif3 p110) (eif3c). [swissprot;acc:q99613]	Low confidence	202.98	198.253	1.02384
	FAU	40s ribosomal protein s30. [swissprot;acc:q05472]	High confidence	223.44	216.875	1.03027
1082	HDC	histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	Low confidence	203.804	199.058	1.02384
	PLEKHF2	phafin 2; ph and fyve domain-containing protein 2. [refseq;acc:nm_024613]	High confidence	220.118	213.685	1.03011
1083	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase 1 (ec 1.3.99.5) (steroid 5-alpha-reductase 1) (sr type 1) (s5ar). [swissprot;acc:p18405]
	TPPP2	protein p25-beta. [swissprot;acc:p59282]	Low confidence	203.939	199.193	1.02383
1084	ELOVL6	elovl family member 6, elongation of long chain fatty acids (fen1/elo2, sur4/elo3-like, yeast); long-chain fatty-acyl elongase. [refseq;acc:nm_024090]		200.38	195.716
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase 2 (ec 1.3.99.5) (steroid 5-alpha-reductase 2) (sr type 2) (5 alpha-sr2). [swissprot;acc:p31213]	High confidence	220.118	213.685	1.03011
1085	DKC1	dyskerin (nucleolar protein nap57) (cbf5 homolog). [swissprot;acc:o60832]		231.007	237.864	1.02968
	TPPP	25 kda brain-specific protein (p25-alpha). [swissprot;acc:o94811]	Low confidence	203.933	199.188	1.02382
1086	no value	similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	High confidence	236.679	243.679	1.02958
	TPPP3	protein cgi-38. [swissprot;acc:q9bw30]	Low confidence	203.9	199.157	1.02382
1087	no value	zinc finger protein 277. [swissprot;acc:q9nrm2]	High confidence	236.679	243.679	1.02958
	PERLD1	cab2. [refseq;acc:nm_033419]	Low confidence	200.375	195.715	1.02381

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.