MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2125 to 2174 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
532	no value	myosin heavy chain, cardiac muscle alpha isoform (myhc-alpha). [swissprot;acc:p13533]	Subtracted	High confidence	112	126	14
	INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]		Low confidence	206.406	200.027	6.379
	SLC2A14	glucose transporter 14. [refseq;acc:nm_153449]	Divided		205.541	199.115	1.03227
	ZNF622	zinc finger-like protein 9. [refseq;acc:nm_033414]		High confidence	250.942	235.004	1.06782
533	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Subtracted		58	44	14
	SEPHS1	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]		Low confidence	206.406	200.027	6.379
	SLC2A1	solute carrier family 2, facilitated glucose transporter, member 1 (glucose transporter type 1, erythrocyte/brain) (hepg2 glucose transporter). [swissprot;acc:p11166]	Divided		205.533	199.112	1.03225
	SLC45A2	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]		High confidence	250.942	235.004	1.06782
534	no value	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
	INPP4A	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]	Subtracted	Low confidence	206.406	200.027	6.379
	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		High confidence	58	44	14
	ZFAND5	zinc finger protein 216. [swissprot;acc:o76080]	Divided	Low confidence	184.361	178.613	1.03218
535	HTATSF1	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	Subtracted		209.347	202.978	6.369
	MYH4	myosin heavy chain, skeletal muscle, fetal (myosin heavy chain iib) (myhc-iib). [swissprot;acc:q9y623]		High confidence	112	126	14
	POLR2H	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	Divided		236.662	252.708	1.0678
	ZFAND6	protein associated with prk1. [refseq;acc:nm_019006]		Low confidence	184.361	178.613	1.03218
536	MYH8	myosin heavy chain, skeletal muscle, perinatal (myhc-perinatal). [swissprot;acc:p13535]	Subtracted	High confidence	112	126	14
	RANBP9	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	Divided	Low confidence	203.519	197.195	1.03207
	RNF7	ring finger protein 7; sensitive to apoptosis gene. [refseq;acc:nm_014245]	Subtracted		203.162	196.796	6.366
	SSB	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Divided	High confidence	242.531	227.136	1.06778
537	ATP9A	potential phospholipid-transporting atpase iia (ec 3.6.1.-). [swissprot;acc:o75110]	Subtracted	Low confidence	202.845	209.189	6.344
	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	Divided	High confidence	229.803	215.301	1.06736
	MEGF11	megf11 protein. [refseq;acc:nm_032445]		Low confidence	207.951	201.517	1.03193
	UBAC1	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	Subtracted	High confidence	10	24	14
538	MEGF10	megf10 protein. [refseq;acc:nm_032446]	Divided	Low confidence	207.949	201.517	1.03192
	PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	Subtracted	High confidence	58	44	14
	POLR2L	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	Divided		237.627	253.604	1.06724
	RANBP9	ran binding protein 9; novel centrosomal protein ranbpm; ran binding protein, centrosomal. [refseq;acc:nm_005493]	Subtracted	Low confidence	203.519	197.195	6.324
539	CRBN	protein x 0001. [refseq;acc:nm_016302]	Divided		199.661	193.489	1.0319
	MEMO1P	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]		High confidence	236.964	252.86	1.06708
	MOBKL3	preimplantation protein 3; likely ortholog of preimplantation protein 3. [refseq;acc:nm_015387]	Subtracted	Low confidence	206.737	200.417	6.32
	MYH2	myosin heavy chain, skeletal muscle, adult 2 (myosin heavy chain iia) (myhc-iia). [swissprot;acc:q9ukx2]		High confidence	112	126	14
540	DNAJB11	dnaj homolog subfamily b member 11 precursor (er-associated dnaj protein 3) (erj3) (er-associated hsp40 co-chaperone) (hdj9) (pwp1- interacting protein 4). [swissprot;acc:q9ubs4]		Low confidence	206.737	200.417	6.32
	PANK3	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]		High confidence	58	44	14
	SEPHS2	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	Divided		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
541	AP1M2	adaptor-related protein complex 1, mu 2 subunit (mu-adaptin 2) (adaptor protein complex ap-1 mu-2 subunit) (golgi adaptor ha1/ap1 adaptin mu-2 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 2) (ap-mu chain family member mu1b). [swissprot;acc:q9y6q5]	Subtracted		205.768	199.453	6.315
	MICAL2	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]	Divided	High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	MYH3	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	Subtracted	High confidence	112	126	14
542	INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]	Divided		222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
	MYH1	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Subtracted	High confidence	112	126	14
	SART1	squamous cell carcinoma antigen recognized by t cells 1; u4/u6.u5 tri-snrnp-associated 110 kda protein; ige autoantigen; sart1(259) protein; sart1(800) protein. [refseq;acc:nm_005146]		Low confidence	200.271	193.957	6.314
543	no value	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]		High confidence	112	126	14
	AP1M1	adaptor-related protein complex 1, mu 1 subunit (mu-adaptin 1) (adaptor protein complex ap-1 mu-1 subunit) (golgi adaptor ha1/ap1 adaptin mu-1 subunit) (clathrin assembly protein assembly protein complex 1 medium chain 1) (clathrin coat assembly protein ap47) (clathrin coat associated protein ap47) (ap-mu chain family member mu1a). [swissprot;acc:q9bxs5]		Low confidence	205.75	199.452	6.298
	SEPHS1	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]	Divided	High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189
544	INPP4A	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]		High confidence	222.156	208.201	1.06703
				Low confidence	206.406	200.027	1.03189

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.