MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 2101 to 2150 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	Network Comparison Type	red	network_comparison	green
fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	46	FOSL1	Divided	204.642	1.27053	161.068
	102		Subtracted		43.574
fos-related antigen 2. [swissprot;acc:p15408]	44	FOSL2	Divided	204.641	1.2707	161.046
	100		Subtracted		43.595
fragile x mental retardation 1 protein (protein fmr-1) (fmrp). [swissprot;acc:q06787]	1828	FMR1	Divided	202.41	1.01147	200.115
	1863		Subtracted		2.295
fragile x mental retardation syndrome related protein 1. [swissprot;acc:p51114]	1825	FXR1	Divided	202.386	1.0115	200.086
	1861		Subtracted		2.3
fragile x mental retardation syndrome related protein 2. [swissprot;acc:p51116]	1823	FXR2	Divided		1.0115
	1860		Subtracted		2.3
frg1 protein (fshd region gene 1 protein). [swissprot;acc:q14331]	2745	FRG1	Divided	201.476	1.00019	201.514
			Subtracted		0.038
fructose-1,6-bisphosphatase (ec 3.1.3.11) (d-fructose-1,6-bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:p09467]	2561	FBP1	Divided	209.825	1.00169	210.18
			Subtracted		0.355
fructose-1,6-bisphosphatase isozyme 2 (ec 3.1.3.11) (d-fructose-1,6- bisphosphate 1-phosphohydrolase) (fbpase). [swissprot;acc:o00757]	2551	FBP2	Divided	209.766	1.00182	210.148
			Subtracted		0.382
fructose-bisphosphate aldolase a (ec 4.1.2.13) (muscle-type aldolase) (lung cancer antigen ny-lu-1). [swissprot;acc:p04075]	2907	ALDOA	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
fructose-bisphosphate aldolase b (ec 4.1.2.13) (liver-type aldolase). [swissprot;acc:p05062]	2973	ALDOB	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
fructose-bisphosphate aldolase c (ec 4.1.2.13) (brain-type aldolase). [swissprot;acc:p09972]	3087	ALDOC	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	668	FTSJ3		244.495	12.076	232.419
	726		Divided		1.05196
fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	731	FH		208.874	1.05187	219.708
			Subtracted		10.834
fuse binding protein 3 (fragment). [sptrembl;acc:q92946]	2651	FUBP3		217.176	0.232	216.944
	2668		Divided		1.00107
fuse-binding protein-interacting repressor isoform b; siah binding protein 1; pyrimidine tract binding splicing factor; ro ribonucleoprotein-binding protein 1; poly-u binding splicing factor puf60. [refseq;acc:nm_014281]	1864	PUF60		203.071	1.01086	200.89
	1899		Subtracted		2.181
fused toes homolog; likely ortholog of mouse fused toes. [refseq;acc:nm_022476]	2106	AKTIP		221.248	1.54	222.788
	2124		Divided		1.00696
fyve-finger-containing rab5 effector protein rabenosyn-5. [refseq;acc:nm_022340]	2998	ZFYVE20		0.00001	1	0.00001
			Subtracted	0	0	0
fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	848	FZR1	Divided	147.211	1.04184	153.371
	1058		Subtracted		6.16
g protein-coupled receptor 66. [refseq;acc:nm_006056]	2815	NMUR1	Divided	0.00001	1	0.00001
			Subtracted	0	0	0
g-rich sequence factor-1 (grsf-1). [swissprot;acc:q12849]	1847	GRSF1		217.891	2.349	215.542
	1855		Divided		1.0109
g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170]	1608	GSPT1	Subtracted	218.789	3.256	215.533
	1631		Divided		1.01511
g2/mitotic-specific cyclin b1. [swissprot;acc:p14635]	1582	CCNB1		168.098	1.01634	170.844
	1738		Subtracted		2.746
g2/mitotic-specific cyclin b2. [swissprot;acc:o95067]	1580	CCNB2	Divided	168.018	1.01637	170.769
	1735		Subtracted		2.751
ga binding protein alpha chain (gabp-alpha subunit) (transcription factor e4tf1-60) (nuclear respiratory factor-2 subunit alpha). [swissprot;acc:q06546]	852	GABPA		227.596	8.579	219.017
	883		Divided		1.03917
ga binding protein beta-2 chain (gabp-beta-2 subunit) (transcription factor e4tf1-47) (gapbp-2) (nuclear respiratory factor-2 subunit gamma). [swissprot;acc:q06545]	853	no value	Subtracted		8.579
	884		Divided		1.03917

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.