MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2101 to 2150 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
1051	no value	17 beta-hydroxysteroid dehydrogenase. [sptrembl;acc:q13034]	Divided	211.449	217.998	1.03097
	ANXA11	annexin a11 (annexin xi) (calcyclin-associated annexin 50) (cap-50) (56 kda autoantigen). [swissprot;acc:p50995]	Subtracted	219.673	213.378	6.295
1052	KARS	lysyl-trna synthetase (ec 6.1.1.6) (lysine--trna ligase) (lysrs). [swissprot;acc:q15046]		220.291	226.584	6.293
	RDH8	retinol dehydrogenase 8 (all-trans); photoreceptor outer segment all-trans retinol dehydrogenase. [refseq;acc:nm_015725]	Divided	211.449	217.998	1.03097
1053	ANXA7	annexin a7 (annexin vii) (synexin). [swissprot;acc:p20073]	Subtracted	219.655	213.385	6.27
	PSMA5	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	Divided	207.04	200.84	1.03087
1054	no value	60s ribosomal protein l21. [swissprot;acc:p46778]		223.958	217.263	1.03082
	PSMA5	proteasome subunit alpha type 5 (ec 3.4.25.1) (proteasome zeta chain) (macropain zeta chain) (multicatalytic endopeptidase complex zeta chain). [swissprot;acc:p28066]	Subtracted	207.04	200.84	6.2
1055	ASNSD1	hcv ns3-transactivated protein 1. [refseq;acc:nm_019048]	Divided	219.01	212.468	1.03079
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Subtracted	138.705	132.538	6.167
1056	no value	methyltransferase like 2. [refseq;acc:nm_018396]		147.211	153.371	6.16
	ATP6V1A	vacuolar atp synthase catalytic subunit a, ubiquitous isoform (ec 3.6.3.14) (v-atpase a subunit 1) (vacuolar proton pump alpha subunit 1) (v-atpase 69 kda subunit 1) (isoform va68). [swissprot;acc:p38606]	Divided	219.01	212.468	1.03079
1057	ASNS	asparagine synthetase [glutamine-hydrolyzing] (ec 6.3.5.4) (glutamine- dependent asparagine synthetase) (ts11 cell cycle control protein). [swissprot;acc:p08243]
	DYNLT1	cytoplasmic dynein light chain (t-complex testis-specific protein 1 homolog) (protein cw-1). [swissprot;acc:q15763]	Subtracted	147.211	153.371	6.16
1058	ATXN2L	ataxin 2 related protein isoform a; ataxin-2 domain protein. [refseq;acc:nm_007245]	Divided	228.105	221.293	1.03078
	FZR1	fzr1 protein; fizzy-related protein; cdc20-like 1b. [refseq;acc:nm_016263]	Subtracted	147.211	153.371	6.16
1059	no value	ataxin 2; olivopontocerebellar ataxia 2, autosomal dominant. [refseq;acc:nm_002973]	Divided	228.105	221.293	1.03078
	PCSK5	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	Subtracted	147.211	153.371	6.16
1060	NLK	nemo-like kinase; likely ortholog of mouse nemo like kinase. [refseq;acc:nm_016231]	Divided	218.162	211.648	1.03078
	SEPT6	septin 6. [swissprot;acc:q14141]	Subtracted	126.604	120.463	6.141
1061	AP3M1	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]		217.323	211.185	6.138
	ERC1	elks protein. [refseq;acc:nm_015064]	Divided	218.162	211.648	1.03078
1062	BRP44	brain protein 44. [swissprot;acc:o95563]	Subtracted	126.215	120.078	6.137
	ZNF174	zinc finger protein 174 (aw-1). [swissprot;acc:q15697]	Divided	269.963	278.239	1.03066
1063	no value	zinc finger imprinted 2. [swissprot;acc:q9nzv7]		269.96	278.232	1.03064
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Subtracted	126.215	120.078	6.137
1064	AP3M2	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]		217.315	211.183	6.132
	ZNF24	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]	Divided	269.955	278.221	1.03062
1065	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	125.526	119.402	6.124
	ZSCAN12	zinc finger protein 305. [swissprot;acc:o43309]	Divided	269.954	278.219	1.03062
1066	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	124.434	118.318	6.116
	ZNF18	zinc finger protein 18 (zinc finger protein kox11) (fragment). [swissprot;acc:p17022]	Divided	269.956	278.223	1.03062
1067	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Subtracted	213.552	207.463	6.089
	ZNF215	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Divided	269.956	278.223	1.03062
1068	NDUFB9	nadh-ubiquinone oxidoreductase b22 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b22) (ci-b22). [swissprot;acc:q9y6m9]	Subtracted	212.345	206.339	6.006
	ZNF274	zinc finger protein 274 (zinc finger protein sp2114) (zinc finger protein hfb101) (zinc finger protein zfp2) (zf2). [swissprot;acc:q96gc6]	Divided	269.953	278.215	1.03061
1069	DPH1	candidate tumor suppressor in ovarian cancer 2. [refseq;acc:nm_080822]	Subtracted	229.243	235.246	6.003
	ZNF232	zinc finger protein 232. [swissprot;acc:q9uny5]	Divided	269.954	278.218	1.03061
1070	GIT2	arf gtpase-activating protein git2 (g protein-coupled receptor kinase- interactor 2). [swissprot;acc:q14161]	Subtracted	216.78	222.782	6.002
	ZNF394	zinc finger protein 99. [refseq;acc:nm_032164]	Divided	269.954	278.218	1.03061
1071	no value	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]		231.277	238.356
	MPHOSPH10	u3 small nucleolar ribonucleoprotein protein mpp10 (m phase phosphoprotein 10). [swissprot;acc:o00566]	Subtracted	241.496	235.508	5.988
1072	PPA1	inorganic pyrophosphatase (ec 3.6.1.1) (pyrophosphate phospho- hydrolase) (ppase). [swissprot;acc:q15181]		224.307	230.242	5.935
	ZNF213	zinc finger protein 213 (putative transcription factor cr53). [swissprot;acc:o14771]	Divided	269.954	278.217	1.03061
1073	PPA2	inorganic pyrophosphatase 2 isoform 1. [refseq;acc:nm_176869]	Subtracted	224.307	230.242	5.935
	WBP2	ww domain binding protein 2 (wbp-2). [swissprot;acc:q969t9]	Divided	216.901	210.485	1.03048
1074	AIPL1	aryl-hydrocarbon interacting protein-like 1. [swissprot;acc:q9nzn9]	Subtracted	224.307	230.242	5.935
	COPB2	coatomer beta' subunit (beta'-coat protein) (beta'-cop) (p102). [swissprot;acc:p35606]	Divided	174.387	179.697	1.03045
1075	AIP	ah receptor-interacting protein (aip) (immunophilin homolog ara9) (hbv-x associated protein 2). [swissprot;acc:o00170]	Subtracted	224.307	230.242	5.935
	COPG	coatomer gamma subunit (gamma-coat protein) (gamma-cop). [swissprot;acc:q9y678]	Divided	174.387	179.697	1.03045

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.